Contakt

Koblihová Barbora

Groups: Staff, Doctoral Student, Master Student, LEM

Doctoral training

Genetic biomarkers of tumors and aging.

Clonal hematopoiesis of indeterminate potential (CHIP) has recently been described as an age-related condition manifested by the accumulation of somatic mutations in cells of the hematopoietic system. Although this condition is not accompanied by any morphological features of hematological neoplasia, the incidence of CHIP correlates with increased overall mortality and the risk of developing malignant transformation of hematopoietic cells, as well as cardiovascular disease. The investigation of possible links between CHIP, aging, and ischemic stroke is the main aim of this study. We will use various techniques, including FACS, MACS, and advanced deep sequencing allowing highly sensitive detection of mutations in samples of stroke patients. The analysis of immune cells in the blood and also cells in atherosclerotic plaques will be of special interest.

Specialization: Pediatrics.
Status: Ongoing from 2019.
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