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Štěpánková Jana
E-mail:
jana.stepankova03@upol.cz
Groups:
BACHELOR STUDENT
Bachelor training
Preclinical development of 68Ga labelled peptides for glioblastoma imaging
This work is focused on preclinical testing of selected peptides labelled with 68Ga as potential radiodiagnostics for glioblastoma multiforme. The main goal of the study is to determine in vitro characteristics of studied peptides, their in vivo behaviour in mice and to evaluate the potential of 68Ga labelled peptides for diagnosis of glioblastoma multiforme using positron emisson tomography.
Supervisor:
Petřík Miloš Assoc. Prof., PharmDr., Ph.D.
Status:
Graduated from 2014 to 2015.
Journals
Metallacarborane Sulfamides: Unconventional, Specific, and Highly Selective Inhibitors of Carbonic Anhydrase IX.
Journal of Medicinal Chemistry.
2019,
62(21),
9560-9575,
ISSN: 0022-2623,
PMID: 31568723,
Preclinical Evaluation of Radiolabeled Peptides for PET Imaging of Glioblastoma Multiforme.
Molecules.
2019,
24(13),
pii: E2496,
ISSN: 1420-3049,
PMID: 31288488,
Intellectual property
CHOLYL HYDRAZONES AND THEIR USE IN THE TREATMENT OF TUMOR AND LEUKEMIA DISEASES (Rak)
- Patent: CZ 305607. Granted: 25.11.2015. Ownership: Institute of Chemical Technology Prague, Palacký University Olomouc, Institute of Molecular Genetics CAS. Inventors: RAK Jakub, KAPLÁNEK Robert, ŠTULCOVÁ Tereza, DRAŠAR Pavel, HAVLÍK Martin, BŘÍZA Tomáš, DŽUBÁK Petr, HAJDÚCH Marián, KONEČNÝ Petr, ŠTĚPÁNKOVÁ Jana, KRÁLOVÁ Jarmila, KRÁL Vladimír
Status: Terminated