Institute of Molecular and Translational Medicine

THE EATRIS ANNUAL MEETING LISBON 2020

The EATRIS Annual Meeting conference was held in Lisbon from 11 February to 12 February 2020. EATRIS, the European Research Infrastructure (ERIC), provides a single access point to the expertise and cutting-edge technology required to move a biomarker or potential drug from validation phase to clinical trial phase.

MOLECULAR BASIS OF DISEASES AND MOLECULAR TARGET

Research program aims at identification and description of metabolic pathways, signaling pathways, genetic and epigenetic changes causing human diseases, particularly focusing cancer, inflammatory and infectious diseases.

WELCOME TO INSTITUTE OF MOLECULAR AND TRANSLATIONAL MEDICINE

The institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University in Olomouc is cutting-edge biomedical research institute in the Czech Republic. IMTM is a leading Czech translational medicine institute established in 2010.

EATRIS+ kick-off meeting Lisbon 2020

The EATRIS Annual Meeting Lisbon 2020

BioSpot 2020 - Upcoming 5th Annual Conference

EATRIS Annual Meeting 2020

Inadequate speed of DNA replication harms cancer cells [CZ]

Breakthrough mechanism clarified - medicine to treat alcoholism fights cancer [CZ+ENG]

Featured publications

VAN GOOL, A., F. BIETRIX, E. CALDENHOVEN, K. ZATLOUKAL, A. SCHERER, J. LITTON, G. MEIJER, N. BLOMBERG, A. SMITH, B. MONS, J. HERINGA, W. KOOT, M. SMIT, M. HAJDÚCH, T. RIJNDERS a A.E.

USSI. Bridging the translational innovation gap through good biomarker practice. Nature Reviews. Drug Discovery. 2017, 16(9), 587-588. ISSN 1474-1776 . IF: 57.000. PMID: 28450744

GILLILAND, C.T., D. ZUK, P. KOCIS, M. JOHNSON, S. HAY, M. HAJDÚCH, F. BIETRIX, G. AVERSA, C.P. AUSTIN a A.E.

USSI. Putting translational science on to a global stage. Nature Reviews Drug Discovery. 2016, 15, 217-219. ISSN 1474-1776. IF: 57.000. PMID: 27032820

MAYA-MENDOZA, A., P. MOUDRÝ, J. MERCHUT-MAYA, M. LEE, R. STRAUSS a J. BÁRTEK.

High speed of fork progression induces DNA replication stress and genomic instability. Nature. 2018, 559(7713), 279-284. ISSN 0028-0836. IF: 41.577. PMID: 29950726

ŠKROTT, Z., M. MISTRÍK, K. ANDERSEN, S. FRIIS, D. MAJERA, J. GURSKÝ, T. OŽDIAN, J. BARTKOVA, Z. TURI, P. MOUDRÝ, M. KRAUS, M. MEDVEDÍKOVÁ, J. VÁCLAVKOVÁ, P. DŽUBÁK, I. VROBEL, P. POUCKOVA, J. SEDLACEK, A. MIKLOVICOVA, A. KUTT, J. MATTOVA, C. DRIESSEN, Q. DOU, J. OLSEN, M. HAJDÚCH, B. CVEK, R. DESHAIES a J. BÁRTEK.

Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4. Nature. 2017, 552(7684), 194-199. ISSN 0028-0836. IF: 40.137. PMID: 29211715

XU, G., J. CHAPMAN, I. BRANDSMA, J. YUAN, M. MISTRÍK, P. BOUWMAN, J. BARTKOVA, E. GOGOLA, D. WARMERDAM, M. BAZARAS, J. JASPERS, K. WATANABE, M. PIETERSE, K. KERSBERGEN, W. SOL, P. CELIE, P. SCHOUTEN, B. VAN DEN BROEK, A. SALMAN, M. NIEUWLAND, I. DE RINK, J. DE RONDE, K. JALINK, S. BOULTON, J. CHEN, D. VAN GENT, J. BÁRTEK, J. JONKERS, P. BORST a S. ROTTENBERG.

REV7 counteracts DNA double-strand break resection and affects PARP inhibition. Nature. 2015, 521(7553), 541-544. ISSN 0028-0836. IF: 38.138. PMID: 25799992

DIETLEIN, F., B. KALB, M. JOKIC, E. NOLL, A. STRONG, L. THARUN, L. OZRETIC, H. KUNSTLINGER, K. KAMBARTEL, W. RANDERATH, C. JUNGST, A. SCHMITT, A. TORGOVNICK, A. RICHTERS, D. RAUH, F. SIEDEK, T. PERSIGEHL, C. MAUCH, J. BARTKOVA, A. BRADLEY, M. SPRICK, A. TRUMPP, R. RAD, D. SAUR, J. BÁRTEK, J. WOLF, R. BUTTNER, R. THOMAS a H. REINHARDT.

A Synergistic Interaction between Chk1-and MK2 Inhibitors in KRAS-Mutant Cancer. Cell. 2015, 162(1), 146-159. ISSN 0092-8674. IF: 28.710. PMID: 26140595

ALL PUBLICATIONS