PhD Club: Investigation of Paclitaxel Off-Target Effects and the Anticancer Mechanisms of Artemisinins: Methodological Approaches and Challenges by Ema Heffnerová
Wednesday December 11, 2025 / 9 AM / Seminary room 1.09
Institute of Molecular and Translational Medicine
Our mission is to perform basic and translational biomedical research with an aim to better understand the underlying cause of human infectious diseases and cancer, and to develop future human medicines, medical devices and diagnostics. Our vision is to facilitate private-public partnership and research collaboration, and to integrate member researchers into international platforms.
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Czech Republic steps into the EATRIS Spotlight with a focus on Precision and Personalised Health – from Discovery to Patient
Spotlight on the Czech Republic! Following the handover from Portugal this week in Lisbon, theCzech Republic has now officially stepped into the EATRIS Spotlight programme.
CACR 2025: From fundamental cancer research to the patient’s bedside
From 24 to 26 November, more than 300 leading figures from Czech and international scientific and biomedical communities gathered in Olomouc for the Czech Annual Cancer Research Meeting.
Phd Club: Dibenzyldithiocarbamate protects cells from cuproptosis and prevents NPL4 aggregation by Martin Loffelmann
Wednesday December 2, 2025 / 9 AM / Seminary room 1.09
Alžběta Srovnalová presented her work at the CytoData 2025 conference in Berlin
Our colleague Alžběta Srovnalová presented “High Content Morphology Profiling Enables Discovery Of Autophagy-Modulating Therapeutics” at the CytoData 2025 conference on 20–21 November 2025, in Berlin.
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Featured publications
Direct-to-biology, automated, nano-scale synthesis, and phenotypic screening-enabled E3 ligase modulator discovery.
Nature Communications.
2023,
14(1),
8437,
ISSN: 2041-1723,
IF: 16.6,
PMID: 38114468.
The isocyanide SN2 reaction.
Nature Communications.
2023,
14(1),
5807,
ISSN: 2041-1723,
IF: 16.6,
PMID: 37726293.
Increased blood reactive oxygen species and hepcidin in obstructive sleep apnea precludes expected erythrocytosis.
American Journal of Hematology.
2023,
98(8),
1265-1276,
ISSN: 0361-8609 ,
IF: 12.8,
PMID: 37350302.
Pathogenesis of Alzheimer's disease: Involvement of the choroid plexus.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association.
2023,
-,
-,
ISSN: 1552-5260,
IF: 16.655,
PMID: 36825691.
Synthesis of Polycyclic Hetero-Fused 7-Deazapurine Heterocycles and Nucleosides through C-H Dibenzothiophenation and Negishi Coupling.
Journal of the American Chemical Society.
2022,
144(42),
19437-19446,
ISSN: 0002-7863,
IF: 16.383,
PMID: 36245092.
Visualization of Sentinel Lymph Nodes with Mannosylated Fluorescent Nanodiamonds.
Advanced Functional Materials.
2022,
32(23),
2109960,
ISSN: 1616-301X,
IF: 18.808,
Lipidomic profiling of human serum enables detection of pancreatic cancer.
Nature Communications.
2022,
13(1),
124,
ISSN: 2041-1723,
IF: 14.919,
PMID: 35013261.
RNA-interference screen for p53 regulators unveils a role of WDR75 in ribosome biogenesis.
Cell Death and Differentiation.
2022,
29(3),
687-696,
ISSN: 1350-9047,
IF: 15.828,
PMID: 34611297.
Establishing community reference samples, data and call sets for benchmarking cancer mutation detection using whole-genome sequencing.
Nature Biotechnology.
2021,
39(9),
1151-60,
ISSN: 1087-0156,
IF: 54.908,
PMID: 34504347.
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