Papers published in Top 10% journals in the field
PERINA, M.,
M. KISS,
G. MOTYAN,
E. SZCZYRBOVA,
M. ELIÁŠ,
V. STUDENT,
D. KURFÜRSTOVÁ,
M. KOVALOVA,
L. MADA,
J. BOUCHAL,
E. FRANK a
R. JORDA.
A-ring-fused pyrazoles of dihydrotestosterone targeting prostate cancer cells via the downregulation of the androgen receptor.
European Journal of Medicinal Chemistry.
2023,
249,
115086,
ISSN 0223-5234,
IF: 7.088,
PMID: 36682291
STEJSKAL, P.,
H. GODARZI,
J. SROVNAL,
M. HAJDÚCH,
L. VAN ´T VEER a
M. MAGBUNUA.
Circulating tumor nucleic acids: biology, release mechanisms, and clinical relevance.
Molecular Cancer.
2023,
22(1),
15,
ISSN 1476-4598,
IF: 41.444,
PMID: 36681803
VALENTA, M.,
M. BOLEK,
A. MCKUNE,
B. SLADECKOVA,
F. NEULS,
R. BAJGAR a
I. KLIMESOVA.
Acute pre-exercise hydrogen rich water intake does not improve running performance at maximal aerobic speed in trained track and field runners: A randomized, double-blind, placebo-controlled crossover study.
PLoS One.
2022,
17(12),
e0279307,
ISSN 1932-6203,
IF: 3.752,
PMID: 36538554
REISSIG, F.,
K. ZACHSLER,
Z. NOVÝ,
M. PETŘÍK,
K. BENDOVÁ,
D. KURFÜRSTOVÁ,
J. BOUCHAL,
M. ĹUDIK,
F. BRANDT,
K. KOPKA,
M. KHOYLOU,
H.J. PIETZSCH,
M. HAJDÚCH a
C. MAMAT.
Modulating the pharmacokinetic profile of Actinium-225-labeled macropa-derived radioconjugates by dual targeting of PSMA and albumin.
Theranostics.
2022,
12(17),
7203-7215,
ISSN 1838-7640,
IF: 11.6,
PMID: 36438496
BARUCIC, D.,
S. KAUSHIK,
J. KYBIC,
J. STANKOVÁ,
P. DŽUBÁK a
M. HAJDÚCH.
Characterization of drug effects on cell cultures from phase-contrast microscopy images.
Computers in Biology and Medicine.
2022,
151,
106171,
ISSN 0010-4825,
IF: 6.698,
PMID: 36306582
BORKOVÁ, L.,
I. FRYDRYCH,
B. VRÁNOVÁ,
N. JAKUBCOVÁ,
B. LIŠKOVÁ,
P. DŽUBÁK,
P. PAVLIŠ,
M. HAJDÚCH a
M. URBAN.
Lupane derivatives containing various aryl substituents in the position 3 have selective cytostatic effect in leukemic cancer cells including resistant phenotypes.
European Journal of Medicinal Chemistry.
2022,
244,
114850,
ISSN 0223-5234,
IF: 7.088,
PMID: 36283179
YANG, C.,
L. POSTOVA SLAVETINSKA,
M. FLEUTI,
B. KLEPETAROVA,
M. TICHÝ,
S. GURSKÁ,
P. PAVLIŠ,
P. DŽUBÁK,
M. HAJDÚCH a
M. HOCEK.
Synthesis of Polycyclic Hetero-Fused 7-Deazapurine Heterocycles and Nucleosides through C-H Dibenzothiophenation and Negishi Coupling.
Journal of the American Chemical Society.
2022,
144(42),
19437-19446,
ISSN 0002-7863,
IF: 16.383,
PMID: 36245092
ŘEZNÍČKOVÁ, E.,
S. KRAJČOVIČOVÁ,
M. PERINA,
A. KOVALOVA,
M. SOURAL a
V. KRYŠTOF.
Modulation of FLT3-ITD and CDK9 in acute myeloid leukaemia cells by novel proteolysis targeting chimera (PROTAC).
European Journal of Medicinal Chemistry.
2022,
243,
114792,
ISSN 0223-5234,
IF: 7.088,
PMID: 36191408
HODOŇ, J.,
I. FRYDRYCH,
Z. TRHLÍKOVÁ,
J. POKORNÝ,
L. BORKOVÁ,
S. BENICKÁ,
M. VLK,
B. LIŠKOVÁ,
A. KUBÍČKOVÁ,
M. MEDVEDÍKOVÁ,
M. PISÁR,
J. ŠAREK,
V. DAS,
A. LIGASOVÁ,
K. KOBERNA,
P. DŽUBÁK,
M. HAJDÚCH a
M. URBAN.
Triterpenoid pyrazines and pyridines - Synthesis, cytotoxicity, mechanism of action, preparation of prodrugs.
European Journal of Medicinal Chemistry.
2022,
243,
114777,
ISSN 0223-5234,
IF: 7.088,
PMID: 36174412
JORDA, R.,
L. HAVLÍČEK,
M. PERINA,
V. VOJACKOVA,
T. POSPÍŠIL,
S. DJUKIC,
J. SKERLOVA,
J. GRUZ,
N. RENESOVA,
P. KLENER,
P. ŘEZÁČOVÁ,
M. STRNAD a
V. KRYŠTOF.
3,5,7-Substituted Pyrazolo[4,3- d]Pyrimidine Inhibitors of Cyclin-Dependent Kinases and Cyclin K Degraders.
Journal of Medicinal Chemistry.
2022,
65(13),
8881-8896,
ISSN 0022-2623,
IF: 8.039,
PMID: 35749742
SIKOROVÁ, K.,
S. MOON,
H. YOON,
A. STRNAD,
J. SONG a
M. PETŘEK.
HLA class II variants defined by next generation sequencing are associated with sarcoidosis in Korean patients.
Scientific Reports.
2022,
12(1),
9302,
ISSN 2045-2322,
IF: 4.380,
PMID: 35661780
KLOS, D.,
M. DUŠEK,
E. SAMOLOVA,
M. ZATLOUKAL,
V. NOZKOVA,
N. NESNAS,
L. PLACKOVA,
R. KOPRNA,
Z. SPISEK,
H. VYLICILOVA,
O. PLIHAL,
K. DOLEZAL,
J. VOLLER,
A. KADLECOVA,
M. STRNAD a
L. PLÍHALOVÁ.
New Water-Soluble Cytokinin Derivatives and Their Beneficial Impact on Barley Yield and Photosynthesis.
Journal of Agricultural and Food Chemistry.
2022,
70(23),
7288-7301,
ISSN 0021-8561,
IF: 5.279,
PMID: 35658447
WOLRAB, D.,
R. JIRASKO,
E. CIFKOVA,
M. HORING,
D. MEI,
M. CHOCHOLOUSKOVA,
O. PETERKA,
J. IDOWIAK,
T. HRNCIAROVA,
L. KUCHAR,
R. AHRENDS,
R. BRUMAROVÁ,
D. FRIEDECKÝ,
G. VIVO-TRUYOLS,
P. SKRHA,
J. SKRHA,
R. KUCERA,
B. MELICHAR,
G. LIEBISCH,
R. BURKHARDT,
M. WENK,
A. CAZENAVE-GASSIOT,
P. KARASEK,
I. NOVOTNY,
K. GREPLOVA,
R. HRSTKA a
M. HOLCAPEK.
Lipidomic profiling of human serum enables detection of pancreatic cancer.
Nature Communications.
2022,
13(1),
124,
ISSN 2041-1723,
IF: 14.919,
PMID: 35013261
RAFFAELE, M.,
K. KOVACOVICOVA,
T. BIAGINI,
O. LO RE,
J. FROHLICH,
S. GIALLONGO,
J. NHAN,
A. GIANNONE,
D. CABIBI,
M. IVANOV,
A. TONCHEV,
M. MISTRÍK,
M. LACEY,
P. DŽUBÁK,
S. GURSKÁ,
M. HAJDÚCH,
J. BÁRTEK,
T. MAZZA,
V. MICALE,
S. CURRAN a
M. VINCIGUERRA.
Nociceptin/orphanin FQ opioid receptor (NOP) selective ligand MCOPPB links anxiolytic and senolytic effects.
Geroscience.
2021,
44(1),
463-483,
ISSN 2509-2715,
IF: 7.713,
PMID: 34820764
MOUDRÝ, P.,
K. CHROMÁ,
S. BURSAC,
S. VOLAREVIC a
J. BÁRTEK.
RNA-interference screen for p53 regulators unveils a role of WDR75 in ribosome biogenesis.
Cell Death and Differentiation.
2022,
29(3),
687-696,
ISSN 1350-9047,
IF: 15.828,
PMID: 34611297
FANG, L.,
B. ZHU,
Y. ZHAO,
W. CHEN,
Z. YANG,
L. KERRIGAN,
K. LANGEBACH,
M. DE MARS,
K. IDLER,
H. JACOB,
Y. ZHENG,
Y. YU,
E. JAEGER,
G. SCHROTH,
O. ABAAN,
K. TALSANIA,
J. LACK,
T. SHEN,
S. STANBOULY,
B. TRAN,
J. SHETTY,
Y. KRIGA,
D. MEERZAMAN,
C. NGUYEN,
V. PETITJEAN,
M. SULTAN,
M. CAM,
M. MEHTA,
T. HUNG,
E. PETERS,
R. KALAMEGHAM,
S. SAHRAEIAN,
M. MOHIYUDDI,
T. GUO,
L. YAO,
L.A. SONG,
H. LAM,
J. DRÁBEK,
P. VOJTA,
R. MAESTRO,
D. GASPAROTTO,
S. KOKS,
E. REIMANN,
A. SCHERER,
J. NORDLUND,
U. LILJEDAHL,
R. JENSEN,
M. PIROOZNIA,
Z. LI,
C. XIAO,
S. SHERRY,
R. KUSKO,
M. MOOS,
E. DONALDSON,
Z. TEZAK,
B. NING,
W. TONG,
J. LI,
P. DUERKEN-HUGHES,
C. CATALANOTTI,
S. MAHESHWARI,
J. SHUGA,
W. LIANG,
J. KEATS,
J. ADKINS,
E. TASSONE,
V. ZISMANN,
T. MCDANIEL,
J. TRENT,
J. FOOX,
D. BUTLER,
C. MASON,
H. HONG,
C. WANG,
W. XIAO a
I. SOMATIC MUTATION WORKING GROUP OF SEQUENCING QUALITY CONTROL PHASE II CONSORTIUM.
Establishing community reference samples, data and call sets for benchmarking cancer mutation detection using whole-genome sequencing.
Nature Biotechnology.
2021,
39(9),
1151-60,
ISSN 1087-0156,
IF: 54.908,
PMID: 34504347
XIAO, W.,
L. FANG,
Y. ZHAO,
J. LACK,
M. GUAN,
B. ZHU,
E. JAEGER,
L. KERRIGAN,
T. BLOMQUIST,
T. HUNG,
M. SULTAN,
K. IDLER,
A. SCHERER,
R. KUSKO,
M. MOOS,
C. XIAO,
S. SHERRY,
O. ABAAN,
W. CHEN,
X. CHEN,
J. NORDLUND,
U. LILJEDAHL,
R. MAESTRO,
M. POLANO,
J. DRÁBEK,
P. VOJTA,
S. KOKS,
E. REIMANN,
B. MADALA,
T. MERCER,
C. MILLER,
H. JACOB,
T. TRUONG,
A. MOSHREFI,
A. NATARAJAN,
A. GRANAT,
G. SCHROTH,
R. KALAMEGHAM,
E. PETERS,
V. PETITJEAN,
A. WALTON,
T. SHEN,
K. TALSANIA,
C. VERA,
K. LANGEBACH,
M. DE MARS,
J. HIPP,
J. WILLEY,
J. WANG,
J. SHETTY,
Y. KRIGA,
A. RAZIUDDIN,
B. TRAN,
Y. ZHENG,
Y. YU,
M. CAM,
P. JAILWALA,
C. NGUYEN,
D. MEERZAMAN,
Q. CHEN,
B. ERNEST,
U. MEHRA,
R. JENSEN,
W. JONES,
J. LI,
B. PAPAS,
M. PIROOZNIA,
Y. CHEN,
F. SEIFUDDIN,
Z. LI,
X. LIU,
W. RESCH,
J. WANG,
L. WU,
G. YAVAS,
C. MILES,
B. NING,
W. TONG,
C. MASON,
E. DONALDSON,
S. LABABIDI,
L. STAUDT,
Z. TEZAK,
H. HONG a
C. WANG.
Toward best practice in cancer mutation detection with whole-genome and whole-exome sequencing.
Nature Biotechnology.
2021,
39(9),
1141-50,
ISSN 1087-0156,
IF: 54.908,
PMID: 34504346
POKORNÝ, J.,
D. OLEJNÍKOVÁ,
I. FRYDRYCH,
B. LIŠKOVÁ,
S. GURSKÁ,
S. BENICKÁ,
J. ŠAREK,
J. KOTULOVÁ,
M. HAJDÚCH,
P. DŽUBÁK a
M. URBAN.
Substituted dienes prepared from betulinic acid - Synthesis, cytotoxicity, mechanism of action, and pharmacological parameters.
European Journal of Medicinal Chemistry.
2021,
224,
113706,
ISSN 0223-5234,
IF: 6.514,
PMID: 34311159
MISTRÍK, M.,
Z. ŠKROTT,
P. MULLER,
A. PANACEK,
L. HOCHVALDOVA,
K. CHROMÁ,
T. BUCHTOVÁ,
V. VANDOVA,
L. KVÍTEK a
J. BÁRTEK.
Microthermal-induced subcellular-targeted protein damage in cells on plasmonic nanosilver-modified surfaces evokes a two-phase HSP-p97/VCP response.
Nature Communications.
2021,
12(1),
713,
ISSN 2041-1723,
IF: 12.121,
PMID: 33514738
GONZALES, G.,
J. HODOŇ,
A. KAZAKOVA,
C. D´ACUNTO,
P. KANOVSKY,
M. URBAN a
M. STRNAD.
Novel pentacyclic triterpenes exhibiting strong neuroprotective activity in SH-SY5Y cells in salsolinol- and glutamate-induced neurodegeneration models.
European Journal of Medicinal Chemistry.
2021,
213,
113168,
ISSN 0223-5234,
IF: 5.573,
PMID: 33508480
VANDA, D.,
V. CANALE,
S. CHAUMONT-DUBEL,
R. KURCZAB,
G. SATALA,
K. P.,
M. KRAWCZYK,
W. PIETRUS,
K. BLICHARZ,
E. PEKALA,
A. BOJARSKI,
P. POPIK,
P. MARIN,
M. SOURAL a
P. ZAJDEL.
Imidazopyridine-Based 5-HT 6 Receptor Neutral Antagonists: Impact of N1-Benzyl and N1-Phenylsulfonyl Fragments on Different Receptor Conformational States.
Journal of Medicinal Chemistry.
2021,
64(2),
1180-1196,
ISSN 0022-2623,
IF: 6.205,
PMID: 33439019
POLISHCHUK, P.
CReM: chemically reasonable mutations framework for structure generation.
Journal of Cheminformatics.
2020,
12(1),
28,
ISSN 1758-2946,
IF: 5.326,
PMID: 33430959
URBAN, M.,
V. ŠLACHTOVÁ a
L. BRULÍKOVÁ.
Small organic molecules targeting the energy metabolism of Mycobacterium tuberculosis.
European Journal of Medicinal Chemistry.
2021,
212,
113139,
ISSN 0223-5234 ,
IF: 5.573,
PMID: 33422979
KRAJČOVIČOVÁ, S.,
R. JORDA,
D. VANDA,
M. SOURAL a
V. KRYŠTOF.
1,4,6-Trisubstituted imidazo[4,5-c]pyridines as inhibitors of Bruton's tyrosine kinase.
European Journal of Medicinal Chemistry.
2020,
211,
113094,
ISSN 0223-5234,
IF: 5.573,
PMID: 33340912
SVEC, P.,
Z. NOVÝ,
J. KUCKA,
M. PETŘÍK,
O. SEDLACEK,
M. KUCHAR,
B. LIŠKOVÁ,
M. MEDVEDÍKOVÁ,
K. KOLOUCHOVA,
O. GROBORZ,
L. LOUKOTOVA,
R. KONEFAL,
M. HAJDÚCH a
M. HRUBY.
Iodinated Choline Transport-Targeted Tracers.
Journal of Medicinal Chemistry.
2020,
63(24),
15960–15978,
ISSN 0022-2623,
IF: 6.205,
PMID: 33271015
RUČILOVÁ, V.,
A. SWIERRCZEK,
D. VANDA,
P. FUNK,
B. LEMROVÁ,
A. GAWALSKA,
A. BUCKI,
B. NOWAK,
M. ZADROZNA,
K. POCIECHA,
M. SOURAL,
E. WYSKA,
M. PAWLOWSKI,
G. CHLON-RZEPA a
P. ZAJDEL.
New imidazopyridines with phosphodiesterase 4 and 7 inhibitory activity and their efficacy in animal models of inflammatory and autoimmune diseases.
European Journal of Medicinal Chemistry.
2020,
209,
112854,
ISSN 0223-5234,
IF: 5.573,
PMID: 33022582
SVOBODOVA, L.,
M. DVORAKOVA,
M. RUCKI,
K. KEJLOVA,
H. KANDAROVA,
H. KOLÁŘOVÁ,
M. MANNERSTROM a
T. HEINONEN.
Safety testing of adult novelties using in vitro methods.
Regulatory Toxicology and Pharmacology.
2020,
117,
104780,
ISSN 0273-2300,
IF: 2.652,
PMID: 32898621
VERMISOGLOU, E.,
D. PANACEK,
K. JAYARAMULU,
M. PYKAL,
I. FREBORT,
M. KOLÁŘ,
M. HAJDÚCH,
R. ZBOŘIL a
M. OTYEPKA.
Human virus detection with graphene-based materials.
Biosensors & Bioelectronics.
2020,
166,
112436,
ISSN 0956-5663,
IF: 10.257,
PMID: 32750677
PETŘÍK, M.,
E. UMLAUFOVÁ,
V. RACLAVSKÝ,
A. PALYZOVA,
V. HAVLÍČEK,
J. PFISTER,
C. MAIR,
Z. NOVÝ,
M. POPPER,
M. HAJDÚCH a
C. DECRISTOFORO.
68 Ga-labelled desferrioxamine-B for bacterial infection imaging.
European Journal of Nuclear Medicine and Molecular Imaging.
2021,
48(2),
372-382,
ISSN 1619-7070,
IF: 7.081,
PMID: 32734456
DVOŘANOVÁ ŠTĚPÁNKOVÁ, J.,
M. KUGLER,
J. HOLUB,
V. SICHA,
V. DAS,
J. NEKVINDA,
S. EL ANWAR,
M. HAVRANEK,
K.. POSPISILOVA,
M. FABRY,
V. KRAL,
M. MEDVEDÍKOVÁ,
S. MATEJKOVA,
B. LIŠKOVÁ,
S. GURSKÁ,
P. DŽUBÁK,
J. BRYNDA,
M. HAJDÚCH,
B. GRUNER a
P. ŘEZÁČOVÁ.
Sulfonamido Carboranes as Highly Selective Inhibitors of Cancer-Specific Carbonic Anhydrase IX.
European Journal of Medicinal Chemistry.
2020,
200,
112460,
ISSN 0223-5234,
IF: 5.572,
PMID: 32505851
KEJLOVA, K.,
H. BENDOVA,
J. CHRZ,
M. DVORAKOVA,
L. SVOBODOVA,
A. VLKOVA,
L. KUBAC,
R. KORINKOVA,
J. CERNY,
D. OCADLIKOVA,
M. RUCKI,
T. HEINONEN,
D. JIROVA,
S. LETASIOVA,
H. KANDAROVA a
H. KOLÁŘOVÁ.
Toxicological Testing of a Photoactive Phthalocyanine-Based Antimicrobial Substance.
Regulatory Toxicology and Pharmacology.
2020,
115,
104685,
ISSN 0273-2300 ,
IF: 2.652,
PMID: 32454236
CHYRA, Z.,
T. SEVCIKOVA,
P. VOJTA,
J. PUTEROVA,
L. BROZOVA,
K. GROWKOVA,
J. FILIPOVA,
M. ZATOPKOVA,
S. GROSICKI,
A. BARCHNICKA,
W. JEDRZEJCAK,
A. WASCUK-GAJDA,
A. JUNGOVA,
A. MIKULASOVA,
M. HAJDÚCH,
M. MOKREJS,
L. POUR,
M. STORK,
L. HARVANOVA,
M. MISTRÍK,
G. MIKALA,
P. ROBAK,
A. CZYZ,
J. DEBSKI,
L. USNARSKA-ZUBKIEWICZ,
A. JURCZYSZYN,
L. STEJSKAL,
G. MORGAN,
F. KRYUKOV,
E. BUDINSKA,
M. SIMICEK,
T. JELINEK,
M. HRDINKA a
R. HAJEK.
Heterogenous mutation spectrum and deregulated cellular pathways in aberrant plasma cells underline molecular pathology of light-chain amyloidosis.
Haematologica.
2020,
106(2),
601-604,
ISSN 0390-6078,
IF: 7.570,
PMID: 32381580
FIEDLER, J.,
M. REISER,
P. KOSTAL,
J. KUBALE,
S. OSTRY,
T. HRBAC,
P. KESNEROVA,
T. FADRNA,
K. LANGOVÁ,
R. HERZIG a
D. SKOLOUDIK.
Blood Flow Volume Measurement in Cervical and Intracranial Arteries using Quantitative Magnetic Resonance Angiography and Duplex Sonography (Bocaccia) - A Prospective Observational Study.
Ultraschall in der Medizin.
2020,
42(1),
65-74,
ISSN 0172-4614,
IF: 4.613,
PMID: 32340045
ŘEHULKA, J.,
K. BÜRGLOVÁ,
P. KREJČÍ,
S. GURSKÁ,
P. HRADIL,
M. HAJDÚCH,
P. DŽUBÁK a
J. HLAVÁČ.
Fluorinated derivatives of 2-phenyl-3-hydroxy-4(1H)-quinolinone as tubulin polymerization inhibitors.
European Journal of Medicinal Chemistry.
2020,
192,
112176,
ISSN 0223-5234,
IF: 4.833,
PMID: 32120327
SAID, M.,
W. ELDEHNA,
A. NOCENTINI,
S. FAHIM,
A. BONARDI,
A. ELGAZAR,
V. KRYŠTOF,
D. SOLIMAN,
H. ABDEL-AZIZ,
P. GRATTERI,
S. ABOU-SERI a
C. SUPURAN.
Sulfonamide-based ring-fused analogues for CAN508 as novel carbonic anhydrase inhibitors endowed with antitumor activity: Design, synthesis, and in vitro biological evaluation.
European Journal of Medicinal Chemistry.
2020,
189(2020),
112019,
ISSN 0223-5234,
IF: 4.833,
PMID: 31972394
JORDA, R.,
P. MAGAR,
D. HENDRYCHOVA,
K. PAUK,
M. DIBUS,
E. PILAROVA,
A. IMRAMOVSKY a
V. KRYŠTOF.
Novel modified leucine and phenylalanine dipeptides modulate viability and attachment of cancer cells.
European Journal of Medicinal Chemistry.
2020,
188,
112036,
ISSN 0223-5234,
IF: 4.833,
PMID: 31931341
BORKOVÁ, L.,
I. FRYDRYCH,
N. JAKUBCOVÁ,
R. ADÁMEK,
B. LIŠKOVÁ,
S. GURSKÁ,
M. MEDVEDÍKOVÁ,
M. HAJDÚCH a
M. URBAN.
Synthesis and biological evaluation of triterpenoid thiazoles derived from betulonic acid, dihydrobetulonic acid, and ursonic acid.
European Journal of Medicinal Chemistry.
2019,
185,
111806,
ISSN 0223-5234,
IF: 4.833,
PMID: 31677446
GRUNER, B.,
J. BRYNDA,
V. DAS,
V. SICHA,
J. ŠTĚPÁNKOVÁ,
J. NEKVINDA,
J. HOLUB,
K.. POSPISILOVA,
M. FABRY,
P. PACHL,
V. KRAL,
M. KUGLER,
V. MAŠEK,
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