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Das Viswanath M.Sc., Ph.D.

Impact factor journals

Nucleoside-based anticancer drugs: mechanism of action and drug resistance. Biochemical Pharmacology. 2023, ISSN: 0006-2952 , PMID: 37567317,
New use of Old Drugs: Repurposing of Non-oncology Drugs for Cancer and Oncology Drugs for other Human Diseases. Anti-cancer Agents in Medicinal Chemistry. 2023, 23(10), 1103, ISSN: 1871-5206, PMID: 37271990,
Randomizing for Alzheimer's disease drug trials should consider the cancer history of participants. Brain. 2023, ISSN: 0006-8950, PMID: 37243427,

Books

Laboratory Techniques in Cellular and Molecular Medicine, 1.vyd., Olomouc, Palacky University, 2021, 436 s, Dedication: LO1304, ISBN: 978-80-244-6049-9,

Book chapters

Cell lines and cell culture conditions - 3D cultures , 1.vyd., Olomouc, Palacky University, 2021, 2, 15, Dedication: LO1304, ISBN: 978-80-244-6049-9,
Multiparametric analysis of spheroid integrity by brightfield high-content microscopy , 1.vyd., Olomouc, Palacky University, 2021, 24, 177-182, Dedication: LO1304, ISBN: 978-80-244-6049-9,
A combination of kinetic fluorometric assay and microscopy for the screening of potential anti-tau aggregating agents, 1.vyd., Olomouc, Palacky University, 2021, 41, 317-324, Dedication: LO1304, ISBN: 978-80-244-6049-9,

Doctoral mentorship

Annadurai Narendran M.Sc., Ph.D.

Identification and Characterisation of Tau Minimal Regions as Potential Pharmacological Targets Against Tau Spreading in Tauopathies

Status: Graduated from 2015 to 2023.
Kozlov Ihor

Role of axonal transport and pathology in neurodegeneration

Status: Ongoing from 2023.

Master mentorship

Bechná Eliška

3D spheroids cultures of tumor cell lines for drug discovery studies

Status: Ongoing from 2022.
Pavlíková Martina

Specific pharmacological modulators of tau aggregation and spreading for Alzheimer's disease preclinical studies.

Status: Ongoing from 2022.
Skoupilová Patricie

Examination of mutations in tau on the activity of small molecules against prion-like tau formation in tauopathies

Status: Ongoing from 2023.

Bachelor mentorship

Chudáčková Alice

Biochemical and Cellular Analysis of Amyloid Staining Agents in Models of Tauopathies and Synucleopathies

Status: Ongoing from 2023.
Vrablíková Barbora

Cytotoxicity of microtubule-stabilizing drug laulimalide in hypoxic human colorectal and cervical cancer cells

Status: Graduated from 2018 to 2020.

Open positions

Project: The role of tumor hypoxia in the development of acquired resistance to microtubule-targeted drugs
Supervisors: Das Viswanath M.Sc., Ph.D.
Available: 1
Intended for: Doctoral training
Summary: 1 place in full-time study
Project: A combination of 2D and 3D cell cultures for a smart and effective identification and characterization of anti-hypoxic candidates
Supervisors: Das Viswanath M.Sc., Ph.D.
Available: 1
Intended for: Doctoral training
Summary: Hypoxia is a prominent feature of different solid tumor types. A central component of hypoxic adaptation is the stabilization of hypoxia-inducible factor-1 (HIF-1), a key transcriptional regulator of hypoxia that orchestrates the transcriptional regulation of genes involved in a plethora of cellular processes. Considering the multiple roles of HIF-1 in cancer, interest in novel small-molecule inhibitors of the HIF-1 pathway has steadily increased over the past 10 years. However, despite extensive research, no specific inhibitor of HIF-1 has been brought to the market, making the field still ripe for further exploration. The goal of the present work is to utilize the potential of a combination of 2D and 3D cellular models for identification and characterization of inhibitors of HIF-1 and/or HIF-1 pathway by screening in 2D cultures, and lightsheet microscopy and mass spectrometry studies in spheroid cultures.
Project: An extensive structural and biochemical characterization of tau oligomeric species in Alzheimer’s disease and other tauopathies
Supervisors: Das Viswanath M.Sc., Ph.D.
Available: 1
Intended for: Doctoral training
Summary: An extensive structural and biochemical characterization of tau oligomeric species in Alzheimer’s disease and other tauopathies
Project: The role of tumor hypoxia in the acquisition of resistance to microtubule-targeting drugs
Supervisors: Das Viswanath M.Sc., Ph.D.
Available: 1
Intended for: Doctoral training
Summary: Hypoxia is one of the major factors causing resistance to microtubule-stabilizing drugs (MSDs) and other non-microtubule drugs used in chemotherapy. Hypoxia results in changes in tubulin conformation, expression of tubulin isotypes and metabolic pathways that make cancer cells less susceptible to paclitaxel, a taxane used extensively in the treatment of solid tumors. Recent cellular studies have shown that non-taxane MSDs with a similar mode of microtubule stabilization to paclitaxel is more effective in hypoxic cancer cells than paclitaxel. Due to a different microtubule-binding site, we hypothesize that non-taxane MSDs may have a better cytotoxic effect in cancer cells under hypoxia. The goal of this project is to study the anti-cancer effect of non-taxane MSDs in hypoxic ovarian and cervical cancer cell models.
Project: Systems approaches to understanding aging and neurodegeneration
Supervisors: Das Viswanath M.Sc., Ph.D.
Available: 2
Intended for: Doctoral training
Project: The role of tumor hypoxia in the development of acquired resistance to microtubule-targeted drugs
Supervisors: Das Viswanath M.Sc., Ph.D.
Available: 1
Intended for: Doctoral training
Project: Research and development of agents for cancer, neurodegenerative and infectious diseases
Supervisors: De Sanctis Juan Bautista Ph.D., Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D., Urban Milan Ph.D., Das Viswanath M.Sc., Ph.D.
Available: 5
Intended for: Doctoral training
Project: Role of axonal transport and pathology in neurodegeneration
Supervisors: Das Viswanath M.Sc., Ph.D.
Available: 2
Intended for: Doctoral training
Project: Development of organoid assays for anti-tumour drug screening
Supervisors: Das Viswanath M.Sc., Ph.D.
Available: 2
Intended for: Bachelor training
Project: Biochemical and cellular analysis of amyloid staining agents in models of tauopathies and synucleopathies
Supervisors: Das Viswanath M.Sc., Ph.D.
Available: 2
Intended for: Bachelor training
Project: Drug synergy studies in 3D spheroids cultures of tumour cell lines
Supervisors: Das Viswanath M.Sc., Ph.D.
Available: 2
Intended for: Bachelor training