Contakt

Das Viswanath M.Sc., Ph.D.

Phone: +420 585 632 243
Groups: LEM, Staff, Postdoctoral Fellow

Postdoctoral training

Three-dimensional cell culture assays.

My research focused on the development of cost-effective 3D cell culture assays to produce monoculture or co-culture spheroids of malignant and non-malignant cell lines microtiter plates. The assays are performed using reporter and non-reporter cell lines, automated liquid handling and robotic systems, spectrophotometry, and high-content imaging.

Status: Graduated from 2013 to 2017.

About me

Assistant professor at the Institute of Molecular and Translational Medicine of Palacký University Olomouc in the Czech Republic. I did my BSc (honours in Biosciences) and MSc in Biosciences with a specialisation in Biotechnology from Sri Sathya Sai Institute of Higher Learning, Puttaparthi, India, and PhD in Cell and Molecular Biosciences from Victoria University of Wellington, Wellington, New Zealand. 

 

My current research interests are in two areas: (1) The use of three-dimensional cell cultures as pathophysiological relevant in vitro tumour models for cancer research, particularly drug screening and resistance mechanisms, and (2) Studying the biochemical and biophysical features of tau protein in relation to its role in the pathology of tauopathies, particularly the prion-like spreading of tau in tauopathies, such as frontotemporal dementia and Alzheimer’s disease. 

 

Selected publications

  1. N Annadurai, JB De Sanctis, M Hajdúch, V Das. Tau secretion and propagation: perspectives for potential preventive interventions in Alzheimer's disease and other tauopathies. Experimental Neurology. 2021, 343:113756

  2. V Das, F Bruzzese, P Konečný, F Iannnelli, A Budillon, M Hajdúch. Pathophysiologically-relevant in vitro tumor models for screening of anticancer compounds. Drug Discovery Today. 2015, 20:848.

  3. V Das, J Štěpánková, M Hajdúch, JH Miller. Role of tumor hypoxia in acquisition of resistance to microtubule-stabilizing drugs. Biochimica Biophysica Acta. 2015, 1855:17

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