IMTM

My current interest is medicinal chemistry, especially natural products with various biological activities. Our research consists of organic synthesis, evaluation of activities and mechanism of action. Earlier in my career, I was also involved in nucleic acid research, enzymology and biochemistry in general. In addition, I teach classes on bioorganic chemistry, chemical biology, and chemistry of nucleic acids.

Publications (Impact Factor Journals):

• [23]
  POKORNÝ, J., S. KRAJČOVIČOVÁ, M. HAJDÚCH, M. HOLOUBEK, S. GURSKÁ, P. DŽUBÁK, T. VOLNÁ, I. POPA a M. URBAN. Triterpenic azines, a new class of compounds with selective cytotoxicity to leukemia cells CCRF-CEM. Future Medicinal Chemistry. 2018, 10(5), 483-491. ISSN 1756-8919. IF: 3.566. PMID: 29424548
• [22]
  KRAJČOVIČOVÁ, S., J. STANKOVÁ, P. DŽUBÁK, M. HAJDÚCH, M. SOURAL a M. URBAN. A Synthetic Approach for the Rapid Preparation of BODIPY Conjugates and their use in Imaging of Cellular Drug Uptake and Distribution. Chemistry- A European Journal. 2018, 24(19), 4957-4966. ISSN 0947-6539. IF: 5.317. PMID: 29411907
• [21]
  EIGNEROVA, B., M. TICHÝ, J. KRASULOVA, L. RAROVA, R. CHRISTOVÁ, M. URBAN, B. BEDNARCZYK-CWYNAR, M. HAJDÚCH a J. ŠAREK. Q1_Synthesis and antiproliferative properties of new hydrophilic esters of triterpenic acids. European Journal of Medicinal Chemistry. 2017, 140, 403-420. ISSN 0223-5234. IF: 4.519. PMID: 28987603
• [20]
  ŠIDOVÁ, V., P. ZOUFALÝ, J. POKORNÝ, P. DŽUBÁK, M. HAJDÚCH, I. POPA a M. URBAN. Cytotoxic conjugates of betulinic acid and substituted triazoles prepared by Huisgen Cycloaddition from 30-azidoderivatives. PLOS One. 2017, 12(2), e0171621. ISSN 1932-6203 . IF: 3.057. PMID: 28158265
• [19]
  BORKOVÁ, L., R. ADÁMEK, P. KALINA, P. DRAŠAR, P. DŽUBÁK, S. GURSKÁ, J. ŘEHULKA, M. HAJDÚCH, M. URBAN a J. ŠAREK. Synthesis and Cytotoxic Activity of Triterpenoid Thiazoles Derived from Allobetulin, Methyl Betulonate, Methyl Oleanonate, and Oleanonic Acid. ChemMedChem. 2017, 12(5), 390-398. ISSN 1860-7179 . IF: 2.980. PMID: 28084676
• [18]
  BORKOVÁ, L., S. GURSKÁ, P. DŽUBÁK, R. BURIÁNOVÁ, M. HAJDÚCH, J. ŠAREK, I. POPA a M. URBAN. Lupane and 18α-oleanane derivatives substituted in the position 2, their cytotoxicity and influence on cancer cells. European Journal of Medicinal Chemistry. 2016, 121, 120-131. ISSN 0223-5234 . IF: 4.519. PMID: 27236068
• [17]
  SOURAL, M., J. HODOŇ, N.J. DICKINSON, V. ŠIDOVÁ, S. GURSKÁ, P. DŽUBÁK, M. HAJDÚCH, J. ŠAREK a M. URBAN. Preparation of Conjugates of Cytotoxic Lupane Triterpenes with Biotin. Bioconjugate Chemistry. 2015, 26(12), 2563-70. ISSN 1043-1802. IF: 4.818. PMID: 26537839
• [16]
  KVASNICA, M., M. URBAN, N.J. DICKINSON a J. ŠAREK. Pentacyclic triterpenoids with nitrogen- and sulfur-containing heterocycles: synthesis and medicinal significance. Natural Product Reports. 2015, 20(32), 1303-1330. ISSN 0265-0568. IF: 10.986. PMID: 26030604
• [15]
  BORKOVÁ, L., L. JASILKOVA, J. ŘEHULKA, K. FRISONSOVA, M. URBAN, I. FRYDRYCH, I. POPA, M. HAJDÚCH, N.J. DICKINSON, M. VLK, P. DŽUBÁK a J. ŠAREK. Synthesis of cytotoxic 2,2-difluoroderivatives of dihydrobetulinic acid and allobetulin and study of their impact on cancer cells. European Journal of Medicinal Chemistry. 2015, 96(-), 482-490. ISSN 0223-5234. IF: 3.902. PMID: 25942059
• [14]
  OLSON, A.C., J.N. PATRO, M. URBAN a R.D. KUCHTA. The Energetic Difference between Synthesis of Correct and Incorrect Base Pairs Accounts for Highly Accurate DNA Replication. Journal of the American Chemical Society. 2013, 135(4), 1205-1208. ISSN 0002-7863. IF: 11.444. PMID: 23316816
• [13]
  URBAN, M., M. VLK, P. DŽUBÁK, M. HAJDÚCH a J. ŠAREK. Cytotoxic heterocyclic triterpenoids derived from betulin and betulinic acid. Bioorganic & Medicinal Chemistry. 2012, 20(11), 3666-3674. ISSN 0968-0896. IF: 2.903. PMID: 22551630
• [12]
  URBAN, M., J. ŠAREK, M. KVASNICA, I. TIŠLEROVÁ a M. HAJDÚCH. Triterpenoid Pyrazines and Benzopyrazines with Cytotoxic Activity. Journal of Natural products. 2007, 70(4), 526-532. ISSN 0163-3864. IF: 2.418. PMID: 17371067
• [11]
  URBAN, M., J. ŠAREK, I. TIŠLEROVÁ, P. DŽUBÁK a M. HAJDÚCH. Influence of esterification and modification of A-ring in a group of lupane acids on their cytotoxicity. Bioorganic & Medicinal Chemistry. 2005, 13(19), 5527-5535. ISSN 0968-0896. IF: 2.018. PMID: 16087342
• [10]
  ŠAREK, J., M. KVASNICA, M. URBAN, J. KLINOT a M. HAJDÚCH. Correlation of cytotoxic activity of betulinines and their hydroxy analogues. Bioorganic & Medicinal Chemistry Letters. 2005, 15(19), 4196-4200. ISSN 0960-894X. IF: 2.333. PMID: 16051489
• [9]
  URBAN, M., J. ŠAREK, J. KLINOT, G. KOŘÍNKOVÁ a M. HAJDÚCH. Synthesis of A-seco derivatives of betulinic acid with cytotoxic activity. Journal of Natural Products. 2004, 67(7), 1100-1105. ISSN 0163-3864. IF: 1.849. PMID: 15270560
• [8]
  VLK, M., M. URBAN, T. ELBERT a J. ŠAREK. Synthesis of selectively deuterated and tritiated lupane derivatives with cytotoxic activity. Journal of Radioanalytical and Nuclear Chemistry. 2013, 298(2), 1149-1157. ISSN 0236-5731. IF: 1.415.
• [7]
  BIEDERMANN, D., M. URBAN, M. BUDESINKY, M. KVASNICA a J. ŠAREK. Study of addition of difluorocarbene on double bond of triterpenes. Journal of Fluorine Chemistry. 2013, 148(-), 30-35. ISSN 0022-1139. IF: 1.952.
• [6]
  VLK, M., P. MICOLOVA, M. URBAN, M. KVASNICA, D. SAMAN a J. ŠAREK. N-15-labelled pyrazines of triterpenic acids. Journal of Radioanalytical and Nuclear Chemistry. 2016, 308(2), 733-739. ISSN 0236-5731. IF: 1.282.
• [5]
  DŽUBÁK, P., M. HAJDÚCH, D. VYDRA, A. HÚŠŤOVÁ, M. KVASNICA, D. BIEDERMANN, L. MARKOVÁ, M. URBAN a J. ŠAREK. Pharmacological activities of natural triterpenoids and their therapeutic implications. Natural Product Reports. 2006, 23(3), 394-411. ISSN 0265-0568. IF: 7.325.
• [4]
  URBAN, M., J. KLINOT, I. TIŠLEROVÁ, D. BIEDERMANN, M. HAJDÚCH a I. CISAROVA. Reactions of activated lupane oxo-compounds with diazomethane: An approach to new derivatives of cytotoxic triterpenes. Synthesis-Stuttgart. 2006, 23(-), 3979-3986. ISSN 0039-7881. IF: 2.401.
• [3]
  POKORNÝ, J., K.. HORKA, V. ŠIDOVÁ a M. URBAN. Synthesis and characterization of new conjugates of betulin diacetate and bis(triphenysilyl)betulin with substituted triazole. Monatchefte fur Chemie. 2018, 149(4), 839-845. ISSN 0026-9247. IF: 1.282.
• [2]
  BORKOVÁ, L., J. HODOŇ a M. URBAN. Synthesis of Betulinic Acid Derivatives with Modified A-Rings and their Application as Potential Drug Candidates. Asian Journal of Organic Chemistry. 2018, 7(8), 1542-1560. ISSN 2193-5807. IF: 2.496.
• [1]
  POKORNÝ, J., L. BORKOVÁ a M. URBAN. Click Reactions in Chemistry of Triterpenes - Advances Towards Development of Potential Therapeutics. Current Medical Chemistry. 2018, 25(5), 636-658. ISSN 0929-8673. IF: 3.469.

Book Chapters:

• [3]
  DŽUBÁK, P., M. URBAN a M. HAJDÚCH. Vývoj nových léčiv. In: Molekulární medicína. 1. vyd. Praha: Galén, 2015. Kapitola 11, s. 469-472. ISBN: 978-80-7492-121-6.
• [2]
  URBAN, M., M. KVASNICA, N.J. DICKINSON a J. ŠAREK. Biologically Active Triterpenoids Usable As Prodrugs. In: Terpenoids and Squalene: Biosynthesis, Functions and Health Implications. 1. vyd. New York, USA: Nova Science Publishers, 2015. Kapitola 2, s. 25-50. ISBN: 978-1-63463-656-8.
• [1]
  ŠAREK, J., M. KVASNICA, M. VLK, M. URBAN, P. DŽUBÁK a M. HAJDÚCH. The Potential of Triterpenoids in the Treatment of Melanoma. In: Research on Melanoma – A Glimpse into Current Directions and Future Trends. 1.vyd. Rijeka: InTech, 2011. Kapitola 7, s. 125-158. ISBN: 978-953-307-293-7.