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Telefon: +420 585 632 243
Skupiny: IMTM, LEM, PERSONÁL

O mně

Viswanath Das is a Principal Investigator and Group Leader at the Institute of Molecular and Translational Medicine, Palacký University Olomouc. His research focuses on the aggregation, prion-like seeding, and propagation of disease-associated proteins, including tau, α-synuclein, and amyloid, and on developing therapeutic strategies to inhibit these processes. He leads projects supported by the Czech Science Foundation and the Czech Ministry of Health. He has published more than 40 peer-reviewed articles and supervises postdoctoral, doctoral, and master’s researchers.

Journals

KOZLOV, I., Y. HUNG, S. ROY, C. ALLADI, R. KOURIL, Y. WONG, V. DAS
Repurposed catechol-O-methyltransferase inhibitors tolcapone and entacapone preferentially suppress aggregation and seeding of P301 mutant tau in human neuronal models. British Journal of Pharmacology. 2026, ISSN: 0007-1188, PMID: 42902961,  PDF.
BHISE, P., S. BHISE, S. DASGUPTA, A. NANDY, R. GUNDLA, S. GURSKÁ, P. DŽUBÁK, M. HAJDÚCH, V. DAS, S. THOPATE, P. BADADHE
Design, synthesis, molecular docking and anticancer activity of novel N-(4-(chlorodifluoromethoxy)phenyl)-1 H-pyrrolo[2,3- b]pyridine-5-carboxamide derivatives. RSC Advances. 2026, ISSN: 2046-2069, PMID: 42729957,  PDF.
BHOGAL, I., I. FRYDRYCH, A. MODI, V. PANKAJ, A. KUMAR, A. KHAIRNAR, V. DAS, S. ROY
Naringenin as a dual-target modulator of RAGE-NF-κB signaling and Aβ fibrillization in Alzheimer's disease: integrated computational and experimental analyses. Frontiers in Pharmacology. 2026, 17, 1901236, ISSN: 1663-9812, PMID: 42712578,  PDF.

Books & book chapters

Multiparametric analysis of spheroid integrity by brightfield high-content microscopy , 1.vyd., Olomouc, Palacky University, 2021, 24, 177-182, Dedication: LO1304, ISBN: 978-80-244-6049-9,
Cell lines and cell culture conditions - 3D cultures , 1.vyd., Olomouc, Palacky University, 2021, 2, 15, Dedication: LO1304, ISBN: 978-80-244-6049-9,
ANNADURAI, N., V. DAS
A combination of kinetic fluorometric assay and microscopy for the screening of potential anti-tau aggregating agents, 1.vyd., Olomouc, Palacky University, 2021, 41, 317-324, Dedication: LO1304, ISBN: 978-80-244-6049-9,

Doctoral mentorship

Annadurai Narendran M.Sc., Ph.D.

Identification and Characterisation of Tau minimal regions as Potential Pharmacological Targets against Tau Spreading in Tauopathies

Stav: Absolvoval od 2015 do 2023.

Kozlov Ihor Mgr.

Role of axonal transport and pathology in neurodegeneration

Stav: Ongoing od 2023.

Varečka Alexander

Dysfunction of mitochondria and microglia in tauopathies: effects of pathogenic TAU strains

Stav: Probíhající od 2025.

Master mentorship

Bechná Eliška

3D spheroids cultures of tumor cell lines for drug discovery studies

Stav: Absolvoval od 2022 do 2025.

Pavlíková Martina

Specific pharmacological modulators of tau aggregation and spreading for Alzheimer's disease preclinical studies.

Stav: Absolvoval od 2022 do 2024.

Skoupilová Patricie

Examination of mutations in tau on the activity of small molecules against prion-like tau formation in tauopathies

Stav: Absolvoval od 2023 do 2025.

Bachelor mentorship

Chudáčková Alica

Investigating the biochemical and structural alterations in tau mutants caused by VQIVYK-targeting tau inhibitors

Stav: Absolvoval od 2023 do 2025.

Vrablíková Barbora

Cytotoxicity of microtubule-stabilizing drug laulimalide in hypoxic human colorectal and cervical cancer cells

Stav: Absolvoval od 2018 do 2020.

Volná místa

1 Chemická biologie a experimentální terapie
Projekt: The role of tumor hypoxia in the emergence of acquired resistance to drugs aimed at microtubules
Vedoucí: Das Viswanath M.Sc., Ph.D.
K dispozici: 1
Určeno pro: Doktorské studium
Souhrn: 1 místo v prezenční formě studia
3 Molecular and Translational Medicine
Projekt: Role of axonal transport and pathology in neurodegeneration
Vedoucí: Das Viswanath M.Sc., Ph.D.
K dispozici: 2
Určeno pro: Doctoral training
Projekt: Systems approaches to understanding aging and neurodegeneration
Vedoucí: Das Viswanath M.Sc., Ph.D.
K dispozici: 2
Určeno pro: Doctoral training
Projekt: Research and development of agents for cancer, neurodegenerative and infectious diseases
Vedoucí: De Sanctis Juan Bautista Ph.D., Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D., Urban Milan Ph.D., Das Viswanath M.Sc., Ph.D.
K dispozici: 5
Určeno pro: Doctoral training
5 Molekulární a translační medicína
Projekt: Mitochondrial and microglial dysfunction in tauopathies: effects of pathogenic TAU strains
Vedoucí: Das Viswanath M.Sc., Ph.D.
K dispozici: 1
Určeno pro: Doktorské studium
Souhrn: 1 místo na plný úvazek
Projekt: Investigating Effects of Aggregates of Intrinsically Disordered Proteins on Microglia: Implication for Neurodegenerative Diseases
Vedoucí: Das Viswanath M.Sc., Ph.D.
K dispozici: 1
Určeno pro: Magisterské studium
Souhrn: -
Projekt: Biochemical and cellular analysis of amyloid staining agents in models of tauopathies and synucleopathies
Vedoucí: Das Viswanath M.Sc., Ph.D.
K dispozici: 1
Určeno pro: Magisterské studium
Souhrn: -
Projekt: Generation of 3D human neuronal cultures: application to modeling CNS diseases
Vedoucí: Das Viswanath M.Sc., Ph.D.
K dispozici: 1
Určeno pro: Magisterské studium
Souhrn: -
Projekt: Efficacy of Bruton Tyrosine Kinase Inhibitors Against Neuroinflammation in Neurodegenerative Diseases
Vedoucí: Das Viswanath M.Sc., Ph.D.
K dispozici: 1
Určeno pro: Magisterské studium
Souhrn: -