IMTM

Scientist and pediatrician involved in molecular and translational medicine (disease area oncology and infectious diseases), leader of research program Chemical Biology and Experimental Therapeutics at IMTM. Actively participated in the research of more than 20 national and international projects; member of advisory board of Cancer Research Foundation „Rakovina ve veřejná“, co-founder of spin-off company focused on manufacturing of molecular diagnostics. Published more than >50 papers and books/chapters, >800 SCI citations, H-index 15, Prix de Pharmacie 2007 Ambassade de France – Sanofi-aventis, Premier Prix. 
 
Specialties: 

Molecular and translational medicine 
Oncology 
Drug research and development, MOA, epigenetics, drug resistance  

Publications (Impact Factor Journals):

• [81]
  TEMIGRAZIYEV, B., K. KUCAKOVA, Y. BAIZHIGIT, M. JURÁŠEK, P. DŽUBÁK, M. HAJDÚCH, B.. DOLENSKY, P. DRAŠAR, B. TULEUOV a S. ADEKENOV. Bioavailability and structural study of 20-hydroxyecdysone complexes with cyclodextrins. Steroids. 2019, 18, 30211-3. ISSN 0039-128X. IF: 2.523. PMID: 30458190
• [80]
  DVOŘAN, M., J. VODICKA, J. DOSTÁL, M. HAJDÚCH, P. DŽUBÁK, M. PESKOVA a R. PILKA. Implantation and diagnostics of endometrial receptivity. Česká gynekologie. 2019, 83(4), 291-298. ISSN 1210-7832. IF: ?. PMID: 30441961
• [79]
  TOKARENKO, A., B. LIŠKOVÁ, S. SMOLEN, N. TÁBORSKÁ, M. TICHÝ, S. GURSKÁ, P. PERLÍKOVÁ, I. FRYDRYCH, E. TLOUŠŤOVÁ, P. ZNOJEK, H. MERTLIKOVA-KAISEROVA, L. POSTOVA SLAVETINSKA, R. POHL, B. KLEPETAROVA, N. KHALID, Y. WENREN, R. LAPOSA, P. DŽUBÁK, M. HAJDÚCH a M. HOCEK. Synthesis and Cytotoxic and Antiviral Profiling of Pyrrolo- and Furo-fused 7-Deazapurine Ribonucleosides. Journal of Medicinal Chemistry. 2018, 61(20), 9347-9359. ISSN 0022-2623. IF: 6.253. PMID: 30281308
• [78]
  BRIZA, T., J. KRALOVA, S. RIMPELOVA, M. HAVLIK, R. KAPLANEK, Z. KEJIK, P. MARTASEK, I. MIKULA, P. DŽUBÁK, M. HAJDÚCH, T. RUML a V. KRAL. Pentamethinium salts as ligands for cancer: Sulfated polysaccharide co-receptors as possible therapeutic target. Bioorganic Chemistry. 2019, 73, 74-85. ISSN 0045-2068. IF: 3.929. PMID: 30273836
• [77]
  AGRAWAL, K., V. DAS, N. TÁBORSKÁ, J. GURSKÝ, P. DŽUBÁK a M. HAJDÚCH. Differential Regulation of Methylation-Regulating Enzymes by Senescent Stromal Cells Drives Colorectal Cancer Cell Response to DNA-Demethylating Epi-Drugs. Stem Cells International. 2018, 2018, 6013728. ISSN 1687-966X. IF: 3.989. PMID: 30158986
• [76]
  KONC, J., M. TICHÝ, R. POHL, J. HODEK, P. DŽUBÁK a M. HOCEK. Sugar modified pyrimido[4,5-b]indole nucleosides: synthesis and antiviral activity. MedChemComm. 2018, 8(9), 1856-1862. ISSN 2040-2503. IF: 2.342. PMID: 30108897
• [75]
  JURÁŠEK, M., M. CERNOHORSKA, J. ŘEHULKA, V. SPIWOK, T. SULIMENKO, E. DRABEROVA, M. DARMOSTUK, S. GURSKÁ, I. FRYDRYCH, R. BURIÁNOVÁ, T. RUML, M. HAJDÚCH, P. BARTŮNĚK, P. DRABER, P. DŽUBÁK, P. DRAŠAR a D. SEDLÁK. Estradiol Dimer Inhibits Tubulin Polymerization and Microtubule Dynamics. The Journal of Steroid Biochemistry and Molecular Biology. 2018, 183, 68-79. ISSN 0960-0760. IF: 4.561. PMID: 29803726
• [74]
  MRAZKOVA, B., R. DZIJAK, T. IMRICHOVA, L. KYJACOVA, P. BARATH, P. DŽUBÁK, D. HOLUB, M. HAJDÚCH, Z. NAHACKA, L. ANDERA, P. HOLICEK, P. VASICOVA, O. SAPEGA, J. BÁRTEK a Z. HODNY. Induction, regulation and roles of neural adhesion molecule L1CAM in cellular senescence. Aging. 2018, 10(3), 432-462. ISSN 1945-4589. IF: 4.867. PMID: 29615539
• [73]
  BÜRGLOVÁ, K., G. RYLOVÁ, A. MARKOS, H. PŘICHYSTALOVÁ, M. SOURAL, M. PETRÁČEK, M. MEDVEDÍKOVÁ, G. TEJRAL, B. SOPKO, P. HRADIL, P. DŽUBÁK, M. HAJDÚCH a J. HLAVÁČ. Identification of Eukaryotic Translation Elongation Factor 1-α 1 Gamendazole-Binding Site for Binding of 3-Hydroxy-4(1 H)-quinolinones as Novel Ligands with Anticancer Activity. Journal of Medicinal Chemistry. 2018, 61(7), 3027-3036. ISSN 0022-2623. IF: 6.259. PMID: 29498519
• [72]
  FLODROVÁ, P., P. FLODR, T. PIKA, J. VYMETAL, D. HOLUB, P. DŽUBÁK, M. HAJDÚCH a V. SCUDLA. Cardiac amyloidosis: from clinical suspicion to morphological diagnosis. Pathology. 2018, 50(3), 261-268. ISSN 0031-3025. IF: 2.709. PMID: 29448998
• [71]
  POKORNÝ, J., S. KRAJČOVIČOVÁ, M. HAJDÚCH, M. HOLOUBEK, S. GURSKÁ, P. DŽUBÁK, T. VOLNÁ, I. POPA a M. URBAN. Triterpenic azines, a new class of compounds with selective cytotoxicity to leukemia cells CCRF-CEM. Future Medicinal Chemistry. 2018, 10(5), 483-491. ISSN 1756-8919. IF: 3.566. PMID: 29424548
• [70]
  KRAJČOVIČOVÁ, S., J. STANKOVÁ, P. DŽUBÁK, M. HAJDÚCH, M. SOURAL a M. URBAN. A Synthetic Approach for the Rapid Preparation of BODIPY Conjugates and their use in Imaging of Cellular Drug Uptake and Distribution. Chemistry- A European Journal. 2018, 24(19), 4957-4966. ISSN 0947-6539. IF: 5.317. PMID: 29411907
• [69]
  ŘEHULKA, J., N. ANNADURAI, I. FRYDRYCH, P. DŽUBÁK, M. MILLER, M. HAJDÚCH a V. DAS. Peloruside A-Induced Cell Death in Hypoxia Is p53 Dependent in HCT116 Colorectal Cancer Cells. Journal of Natural Products. 2018, 81(3), 634-640. ISSN 0163-3864. IF: 3.281. PMID: 29400463
• [68]
  SESTAK, S., M. BELLA, T. KLUNDA, S. GURSKÁ, P. DŽUBÁK, F. WÖLS, I. WILSON, V. SLADEK, M. HAJDÚCH, M. POLÁKOVÁ a J. KONA. N-Benzyl Substitution of Polyhydroxypyrrolidines: The Way to Selective Inhibitors of Golgi α-Mannosidase II. ChemMedChem. 2018, 13(4), 373-383. ISSN 1860-7179. IF: 3.225. PMID: 29323461
• [67]
  ŠKROTT, Z., M. MISTRÍK, K. ANDERSEN, S. FRIIS, D. MAJERA, J. GURSKÝ, T. OŽDIAN, J. BARTKOVA, Z. TURI, P. MOUDRÝ, M. KRAUS, M. MEDVEDÍKOVÁ, J. VÁCLAVKOVÁ, P. DŽUBÁK, I. VROBEL, P. POUCKOVA, J. SEDLACEK, A. MIKLOVICOVA, A. KUTT, J. MATTOVA, C. DRIESSEN, Q. DOU, J. OLSEN, M. HAJDÚCH, B. CVEK, R. DESHAIES a J. BÁRTEK. Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4. Nature. 2017, 552(7684), 194-199. ISSN 0028-0836. IF: 40.137. PMID: 29211715
• [66]
  CAMATEROS, P., C. KANAGARATHAM, L. NAJDEKR, D. HOLUB, J. VRBKOVÁ, L. COTE, J. FOURNIER, J. GOURDON, D. CREERY, R. OLIVENSTEIN, F. KOPŘIVA, T. ADAM, D. FRIEDECKÝ, P. DŽUBÁK, M. HAJDÚCH a D. RADZIOCH. Toll-Like Receptor 7/8 Ligand, S28463, Suppresses Ascaris Suum Induced Allergic Asthma in Nonhuman Primates. American Journal of Respiratory Cell and Molecular Biology. 2018, 58(1), 55-65. ISSN 1044-1549. IF: 4.100. PMID: 28850259
• [65]
  MOJZIKOVA, R., P. KOŘALKOVÁ, D. HOLUB, Z. SAXOVA, D. POSPÍŠILOVÁ, D. PROCHAZKOVA, P. DŽUBÁK, M. HORVÁTHOVÁ a V. DIVOKÝ. Two novel mutations (p.(Ser160Pro) and p.(Arg472Cys)) causing glucose-6-phosphate isomerase deficiency are associated with erythroid dysplasia and inappropriately suppressed hepcidin. Blood cells, molecules & diseases. 2017, 69, 23-29. ISSN 1079-9796. IF: 1.882. PMID: 28803808
• [64]
  ANNADURAI, N., K. AGRAWAL, P. DŽUBÁK, M. HAJDÚCH a V. DAS. Microtubule affinity-regulating kinases are potential druggable targets for Alzheimer's disease. Cellular and Molecular Life Sciences. 2017, 74(22), 4159-4169. ISSN 1420-682X. IF: 5.788. PMID: 28634681
• [63]
  OŽDIAN, T., D. HOLUB, Z. MACEČKOVÁ, L. VARANASI, G. RYLOVÁ, J. ŘEHULKA, J. VÁCLAVKOVÁ, H. SLAVÍK, P. MOUDRÝ, P. ZNOJEK, J. STANKOVÁ, J.B. DE SANCTIS, M. HAJDÚCH a P. DŽUBÁK. Proteomic profiling reveals DNA damage, nucleolar and ribosomal stress are the main responses to oxaliplatin treatment in cancer cells. Journal of Proteomics. 2017, 162, 73-85. ISSN 1874-3919 . IF: 3.867. PMID: 28478306
• [62]
  PAJTAS, D., K. KONYA, A. KISS-SZIKSZAI, P. DŽUBÁK, Z. PETHO, Z. VARGA, G. PANYI a T. PATONAY. Optimization of the Synthesis of Flavone-Amino Acid and Flavone-Dipeptide Hybrids via Buchwald-Hartwig Reaction. Journal of Organic Chemistry. 2017, 82(5), 4578-4587. ISSN 0022-3263. IF: 4.849. PMID: 28441016
• [61]
  ŘEHULKA, J., N. ANNADURAI, I. FRYDRYCH, P. ZNOJEK, P. DŽUBÁK, P. NORTHCOTE, J.H. MILLER, M. HAJDÚCH a V. DAS. Cellular effects of the microtubule-targeting agent peloruside A in hypoxia-conditioned colorectal carcinoma cells. Biochimica et Biophysica Acta. 2017, 17, 30124-1. ISSN 0304-4165. IF: 5.083. PMID: 28366502
• [60]
  DAS, V., T. FÜRST, S. GURSKÁ, P. DŽUBÁK a M. HAJDÚCH. Evaporation-reducing Culture Condition Increases the Reproducibility of Multicellular Spheroid Formation in Microtiter Plates. Journal of Visualized Experiments. 2017, 121, doi: 10.3791/55403. ISSN 1940-087X. IF: 1.113. PMID: 28362402
• [59]
  TICHÝ, M., S. SMOLEN, E. TLOUŠŤOVÁ, R. POHL, T. OŽDIAN, K. HEJTMÁNKOVÁ, B. LIŠKOVÁ, S. GURSKÁ, P. DŽUBÁK, M. HAJDÚCH a M. HOCEK. Synthesis and Cytostatic and Antiviral Profiling of Thieno-Fused 7-Deazapurine Ribonucleosides. Journal of Medicinal Chemistry. 2017, 60(6), 2411-2424. ISSN 0022-2623. IF: 5.589. PMID: 28221790
• [58]
  ŠIDOVÁ, V., P. ZOUFALÝ, J. POKORNÝ, P. DŽUBÁK, M. HAJDÚCH, I. POPA a M. URBAN. Cytotoxic conjugates of betulinic acid and substituted triazoles prepared by Huisgen Cycloaddition from 30-azidoderivatives. PLOS One. 2017, 12(2), e0171621. ISSN 1932-6203 . IF: 3.057. PMID: 28158265
• [57]
  VOLLER, J., T. BERES, M. ZATLOUKAL, P. KAMINSKI, P. NIEMANN, K. DOLEZAL, P. DŽUBÁK, M. HAJDÚCH a M. STRNAD. The natural cytokinin 2OH3MeOBAR induces cell death by a mechanism that is different from that of the "classical" cytokinin ribosides. Phytochemistry. 2017, 136, 156-164. ISSN 0031-9422 . IF: 2.779. PMID: 28153445
• [56]
  BORKOVÁ, L., R. ADÁMEK, P. KALINA, P. DRAŠAR, P. DŽUBÁK, S. GURSKÁ, J. ŘEHULKA, M. HAJDÚCH, M. URBAN a J. ŠAREK. Synthesis and Cytotoxic Activity of Triterpenoid Thiazoles Derived from Allobetulin, Methyl Betulonate, Methyl Oleanonate, and Oleanonic Acid. ChemMedChem. 2017, 12(5), 390-398. ISSN 1860-7179 . IF: 2.980. PMID: 28084676
• [55]
  AGRAWAL, K., V. DAS, M. OTMAR, M. KRECMEROVA, P. DŽUBÁK a M. HAJDÚCH. Cell-based DNA demethylation detection system for screening of epigenetic drugs in 2D, 3D, and xenograft models. Cytometry A. 2016, -, -. ISSN 1552-4922 . IF: 3.222. PMID: 27911980
• [54]
  SCHADICH, E., P. DŽUBÁK a M. HAJDÚCH. Role of Salmonella Typhi Vi Antigen and Secretory Systems on Immune Response. Current Pharmaceutical Design. 2016, 22(41), 6251-6260. ISSN 1381-6128. IF: 2.611. PMID: 27573929
• [53]
  JURÁŠEK, M., P. DŽUBÁK, S. RIMPELOVA, D. SEDLÁK, P. KONEČNÝ, I. FRYDRYCH, S. GURSKÁ, M. HAJDÚCH, K. BOGDANOVÁ, M. KOLÁŘ, T. MÜLLER, E. KMONICKOVA, T. RUML, J. HARMATHA a P. DRAŠAR. Trilobolide-steroid hybrids: Synthesis, cytotoxic and antimycobacterial activity. Steroids. 2017, 117(2017), 97-104. ISSN 0039-128X. IF: 2.513. PMID: 27543674
• [52]
  ŠIMKOVÁ, D., G. KHARAISHVILI, G. KOŘÍNKOVÁ, T. OŽDIAN, T. SUCHANKOVA-KLEPLOVA, T. SOUKUP, M. KŘUPKA, A. GALANDÁKOVÁ, P. DŽUBÁK, M. JANÍKOVÁ, J. NAVRATIL, Z. KAHOUNOVA, K. SOUCEK a J. BOUCHAL. The dual role of asporin in breast cancer progression. Oncotarget. 2016, 7(32), 52045-52060. ISSN 1949-2553 . IF: 5.168. PMID: 27409832
• [51]
  BORKOVÁ, L., S. GURSKÁ, P. DŽUBÁK, R. BURIÁNOVÁ, M. HAJDÚCH, J. ŠAREK, I. POPA a M. URBAN. Lupane and 18α-oleanane derivatives substituted in the position 2, their cytotoxicity and influence on cancer cells. European Journal of Medicinal Chemistry. 2016, 121, 120-131. ISSN 0223-5234 . IF: 4.519. PMID: 27236068
• [50]
  DAS, V., T. FÜRST, S. GURSKÁ, P. DŽUBÁK a M. HAJDÚCH. Reproducibility of Uniform Spheroid Formation in 384-Well Plates: The Effect of Medium Evaporation. Journal of Biomolecular Screening. 2016, 21(9), 923-30. ISSN 1087-0571 . IF: 2.444. PMID: 27226477
• [49]
  HRUBY, M., K. AGRAWAL, O. POLICIANOVA, J. BRUS, J. SKOPAL, P. SVEC, M. OTMAR, P. DŽUBÁK, P. STEPANEK a M. HAJDÚCH. Biodegradable system for drug delivery of hydrolytically labile azanucleoside drugs. Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czech Republic. 2016, 160(2), 222-230. ISSN 1213-8118 . IF: 0.894. PMID: 27003313
• [48]
  SCHADICH, E., J. HLAVÁČ, T. VOLNÁ, L. VARANASI, M. HAJDÚCH a P. DŽUBÁK. Effects of Ginger Phenylpropanoids and Quercetin on Nrf2-ARE Pathway in Human BJ Fibroblasts and HaCaT Keratinocytes. BioMed Research International . 2016, 2016, 2016:2173275. ISSN 2314-6133. IF: 2.476. PMID: 26942188
• [47]
  PERLÍKOVÁ, P., G. RYLOVÁ, P. NAUŠ, T. ELBERT, E. TLOUŠŤOVÁ, A. BOURDERIOUX, L. SLAVĚTÍNSKÁ, K. MOTYKA, D. DOLEŽAL, P. ZNOJEK, A. NOVÁ, M. HARVANOVÁ, P. DŽUBÁK, M. ŠILLER, J. HLAVÁČ, M. HAJDÚCH a M. HOCEK. 7-(2-Thienyl)-7-deazaadenosine (AB61), a new potent nucleoside cytostatic with a complex mode of action. Molecular Cancer Therapeutics. 2016, 15(5), 922-937. ISSN 1535-7163 . IF: 5.764. PMID: 26819331
• [46]
  NAUŠ, P., O. CALETKOVÁ, P. PERLÍKOVÁ, L. SLAVĚTÍNSKÁ, E. TLOUŠŤOVÁ, J. HODEK, J. WEBER, P. DŽUBÁK, M. HAJDÚCH a M. HOCEK. Synthesis and biological profiling of 6-or 7-(het)aryl-7-deazapurine 4 '-C-methylribonucleosides. Bioorganic and Medicinal Chemistry. 2015, 23(23), 7422-7438. ISSN 0968-0896 . IF: 2.923. PMID: 26558518
• [45]
  SOURAL, M., J. HODOŇ, N.J. DICKINSON, V. ŠIDOVÁ, S. GURSKÁ, P. DŽUBÁK, M. HAJDÚCH, J. ŠAREK a M. URBAN. Preparation of Conjugates of Cytotoxic Lupane Triterpenes with Biotin. Bioconjugate Chemistry. 2015, 26(12), 2563-70. ISSN 1043-1802. IF: 4.818. PMID: 26537839
• [44]
  BORKOVÁ, L., L. JASILKOVA, J. ŘEHULKA, K. FRISONSOVA, M. URBAN, I. FRYDRYCH, I. POPA, M. HAJDÚCH, N.J. DICKINSON, M. VLK, P. DŽUBÁK a J. ŠAREK. Synthesis of cytotoxic 2,2-difluoroderivatives of dihydrobetulinic acid and allobetulin and study of their impact on cancer cells. European Journal of Medicinal Chemistry. 2015, 96(-), 482-490. ISSN 0223-5234. IF: 3.902. PMID: 25942059
• [43]
  KAPLANEK, R., M. JAKUBEK, J. RAK, Z. KEJIK, M. HAVLIK, B.. DOLENSKY, I. FRYDRYCH, M. HAJDÚCH, M. KOLÁŘ, K. BOGDANOVÁ, J. KRALOVA, P. DŽUBÁK a V. KRAL. Caffeine-hydrazones as anticancer agents with pronounced selectivity toward T-lymphoblastic leukaemia cells. Bioorganic Chemistry. 2015, 60(-), 19-29. ISSN 0045-2068. IF: 2.252. PMID: 25912310
• [42]
  MALNUIT, V., L. SLAVĚTÍNSKÁ, P. NAUŠ, P. DŽUBÁK, M. HAJDÚCH, J. STOLAŘÍKOVÁ, J. SNÁŠEL, I. PICHOVÁ a M. HOCEK. 2-Substituted 6-(Het)aryl-7-deazapurine Ribonucleosides: Synthesis, Inhibition of Adenosine Kinases, and Antimycobacterial Activity. ChemMedChem. 2015, 10(6), 1079-1093. ISSN 1860-7179. IF: 2.980. PMID: 25882678
• [41]
  KAPLANEK, R., M. HAVLIK, B.. DOLENSKY, J. RAK, P. DŽUBÁK, P. KONEČNÝ, M. HAJDÚCH, J. KRALOVA a V. KRAL. Synthesis and biological activity evaluation of hydrazone derivatives based on a Troger's base skeleton. Bioorganic and Medicinal Chemistry. 2015, 23(7), 1651-1659. ISSN 0968-0896. IF: 2.923. PMID: 25737088
• [40]
  BRIZA, T., J. KRALOVA, B.. DOLENSKY, S. RIMPELOVA, Z. KEJIK, T. RUML, M. HAJDÚCH, P. DŽUBÁK, I. MIKULA, P. MARTASEK, P. POUCKOVA a V. KRAL. Striking antitumor activity of a methinium system with incorporated quinoxaline unit obtained by spontaneous cyclization. Chembiochem. 2015, 16(4), 555-558. ISSN 1439-4227. IF: 2.850. PMID: 25630657
• [39]
  RYLOVÁ, G., T. OŽDIAN, L. VARANASI, M. SOURAL, J. HLAVÁČ, D. HOLUB, P. DŽUBÁK a M. HAJDÚCH. Affinity-Based Methods in Drug-Target Discovery. Current Drug Targets. 2015, 16(1), 60-76. ISSN 1389-4501. IF: 3.029. PMID: 25410410
• [38]
  SNÁŠEL, J., P. NAUŠ, J. DOSTÁL, A. HNÍZDA, J. FANFRLÍK, J. BRYNDA, A. BOURDERIOUX, M. DUŠEK, H. DVOŘÁKOVÁ, J. STOLAŘÍKOVÁ, H. ZÁBRANSKÁ, R. POHL, P. KONEČNÝ, P. DŽUBÁK, I. VOTRUBA, M. HAJDÚCH, P. ŘEZÁČOVÁ, V. VEVERKA, M. HOCEK a I. PICHOVÁ. Structural Basis for Inhibition of Mycobacterial and Human Adenosine Kinase by 7-Substituted 7-(Het)aryl-7-deazaadenine Ribonucleosides. Journal of Medicinal Chemistry. 2014, 57(20), 8268-8279. ISSN 0022-2623. IF: 5.447. PMID: 25259627
• [37]
  POSPÍŠILOVÁ, D., D. HOLUB, Z. ŽIDOVÁ, L. SULOVSKÁ, J. HOUDA, V. MIHÁL, I. HADAČOVÁ, L. RADOVÁ, P. DŽUBÁK, M. HAJDÚCH, V. DIVOKÝ a M. HORVÁTHOVÁ. Hepcidin levels in Diamond-Blackfan anemia reflect erythropoietic activity and transfusion dependency. Haematologica. 2014, 99(7), e118-121. ISSN 0390-6078. IF: 5.814. PMID: 24727814
• [36]
  NAUŠ, P., O. CALETKOVÁ, P. KONEČNÝ, P. DŽUBÁK, K. BOGDANOVÁ, M. KOLÁŘ, J. VRBKOVÁ, L. SLAVĚTÍNSKÁ, E. TLOUŠŤOVÁ, P. PERLÍKOVÁ, M. HAJDÚCH a M. HOCEK. Synthesis, cytostatic, antimicrobial, and anti-HCV activity of 6-substituted 7-(het)aryl-7-deazapurine ribonucleosides. Journal of Medicinal Chemistry. 2014, 57(3), 1097-1110. ISSN 0022-2623. IF: 5.447. PMID: 24397620
• [35]
  TYLEČKOVÁ, J., R. HRABAKOVA, K. MAIRYCHOVÁ, P. HALADA, L. RADOVÁ, P. DŽUBÁK, M. HAJDÚCH, S.J. GADHER a H. KOVÁŘOVÁ. Cancer Cell response to Anthracyclines Effects: Mysteries of the Hidden Proteins Associated with These Drugs. International Journal of Molecular Sciences. 2012, 2012(13), 15536-15564. ISSN 1422-0067. IF: 2.464. PMID: 23443080
• [34]
  JURÁŠEK, M., P. DŽUBÁK, D. SEDLÁK, H. DVOŘÁKOVÁ, M. HAJDÚCH, P. BARTŮNĚK a P. DRAŠAR. Preparation, preliminary screening of new types of steroid conjugates and their activities on steroid receptors. Steroids. 2013, 78(-), 356-361. ISSN 0039-128X. IF: 2.716. PMID: 23291595
• [33]
  SPENEROVA, M., P. DŽUBÁK, J. SROVNAL, L. RADOVÁ, R. BURIÁNOVÁ, P. KONEČNÝ, S. ŠÁLKOVÁ, Z. NOVÁK, D. POSPÍŠILOVÁ, J. STARÝ, B.. BLAZEK, J. HAK, T. VOTAVA, P. TIMR, E. KAISEROVA, E. BUBANSKA, V. MIHÁL a M. HAJDÚCH. Combination of prednisolone and low dosed dexamethasone exhibits greater in vitro antileukemic activity than equiactive dose of prednisolone and overcomes prednisolone drug resistence in acute childhood lymphoblastic leukemia. Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czech Republic. 2014, 158(3), 422-427. ISSN 1213-8118. IF: 1.200. PMID: 23128824
• [32]
  KUDELA, M., R. PILKA, M. LUBUSKY, P. HEJTMANEK, P. DŽUBÁK a S. BRYCHTOVÁ. Prognostic importance of selected molecular immunohistochemical markers and DNA ploidy in endometrial cancer. European Journal of Gynaecological Oncology. 2012, 33(2), 159-163. ISSN 0392-2936. IF: 0.577. PMID: 22611955
• [31]
  URBAN, M., M. VLK, P. DŽUBÁK, M. HAJDÚCH a J. ŠAREK. Cytotoxic heterocyclic triterpenoids derived from betulin and betulinic acid. Bioorganic & Medicinal Chemistry. 2012, 20(11), 3666-3674. ISSN 0968-0896. IF: 2.903. PMID: 22551630
• [30]
  KOLLAREDDY, M., D. ZHELEVA, P. DŽUBÁK, P.S. BRAHMKSHATRIYA, M. LEPSIK a M. HAJDÚCH. Aurora kinase inhibitors: Progress towards the clinic. Investigational New Drugs. 2012, 30(6), 2411-2432. ISSN 0167-6997. IF: 3.498. PMID: 22350019
• [29]
  BRULÍKOVÁ, L., P. DŽUBÁK, M. HAJDÚCH a J. HLAVÁČ. Synthesis of Various 5-Alkoxymethyluracil Analogues and Structure-Cytotoxic Activity Relationship Study. Carbohydrate Research. 2011, 346(14), 2136-2144. ISSN 0008-6215. IF: 2.332. PMID: 21864833
• [28]
  BOURDERIOUX, A., P. NAUŠ, P. PERLÍKOVÁ, R. POHL, I. PICHOVÁ, I. VOTRUBA, P. DŽUBÁK, P. KONEČNÝ, M. HAJDÚCH, K.M. STRAY, T. WANG, A.S. RAY, J.Y. FENG, G. BIRKUS, T. CIHLÁŘ a M. HOCEK. Synthesis and Significant Cytostatic Activity of 7-Hetaryl-7-deazaadenosines. Journal of Medicinal Chemistry. 2011, 54(15), 5498-5507. ISSN 0022-2623. IF: 5.248. PMID: 21711054
• [27]
  SOURAL, M., J. HLAVÁČ, P. FUNK, P. DŽUBÁK a M. HAJDÚCH. 2-Phenylsubstituted-3-Hydroxyquinolin-4(1H)-one-Carboxamides: Structure-Cytotoxic Activity Relationship Study. ACS Combinatorial Science. 2011, 13(1), 39-44. ISSN 1520-4766. IF: 3.450. PMID: 21247123
• [26]
  STROHALM, M., P. NOVAK, P. POMPACH, P. DŽUBÁK, P. MAN, D. KAVAN, M. WITT, M. HAJDÚCH a V. HAVLICEK. Utilization of high-accuracy FTICR-MS data in protein quantitation experiments. Journal of Mass Spectrometry. 2009, 44(11), 1565-70. ISSN 1076-5174. IF: 2.940. PMID: 19536796
• [25]
  KOPŘIVA, F., P. DŽUBÁK, J. POTĚŠIL a M. HAJDÚCH. The anti-inflammatory effects of inhaled corticosteroids versus anti-leukotrienes on the lymphocyte P-glycoprotein (PGP) expression in asthmatic children. Journal of Astma. 2009, 46(4), 366-370. ISSN 0277-0903. IF: 1.330. PMID: 19484671
• [24]
  PAPRSKÁŘOVÁ, M., V. KRYŠTOF, R. JORDA, P. DŽUBÁK, M. HAJDÚCH, J. WESIERSKA-GADEK a M. STRNAD. Functional p53 in cells contributes to the anticancer effect of the cyclin-dependent kinase inhibitor roscovitine. Journal of Cellular Biochemistry. 2009, 107(3), 428-437. ISSN 0730-2312. IF: 1.330. PMID: 19308936
• [23]
  SPÁČILOVÁ, L., P. DŽUBÁK, M. HAJDÚCH, S. KŘUPKOVÁ, P. HRADIL a J. HLAVÁČ. Synthesis and cytotoxic activity of various 5-[alkoxy-(4-nitro-phenyl]-methyl]-uracils in their racemic form. Biorganic & Medicinal Chemistry Letters. 2007, 17(23), 6647-6650. ISSN 0960-894X. IF: 2.538. PMID: 17935983
• [22]
  KRYŠTOF, V., P. CANKAR, I. FRYŠOVÁ, J. SLOUKA, G. KONTOPIDIS, P. DŽUBÁK, M. HAJDÚCH, J. SROVNAL, W.F. DE AZAVEDO, M. ORSÁG, M. PAPRSKÁŘOVÁ, J. ROLČÍK, A. LÁTR, P.M. FISCHER a M. STRNAD. 4-Arylazo-3,5-diamino-1H-pyrazole CDK Inhibitors: SAR Study, Crystal Structure in Complex with CDK2, Selectivity, and Cellular Effects. Journal of Medicinal Chemistry. 2006, 49(22), 6500-6509. ISSN 0022-2623. IF: 4.926. PMID: 17064068
• [21]
  VEPŘEK, P., M. HAJDÚCH, P. DŽUBÁK, R. KUKLÍK, J. POLÁKOVÁ a K. BEZOUŠKA. Comblike Dendrimers Containing Tn Antigen Modulate Natural Killing and Induce the Production of Tn Specific Antibodies. Journal of Medicinal Chemistry. 2006, 49(21), 6400-6407. ISSN 0022-2623. IF: 4.926. PMID: 17034145
• [20]
  DŽUBÁK, P., M. HAJDÚCH, R. GAZAK, A. SVOBODOVÁ, J. PSOTOVÁ, D. WALTEROVÁ, P. SEDMERA a V. KREN. New derivatives of silybin and 2,3-dehydrosilybin and their cytotoxic and P-glycoprotein modulatory activity. Bioorganic & Medicinal Chemistry. 2006, 14(11), 3793-3810. ISSN 0968-0896. IF: 2.286. PMID: 16466920
• [19]
  URBAN, M., J. ŠAREK, I. TIŠLEROVÁ, P. DŽUBÁK a M. HAJDÚCH. Influence of esterification and modification of A-ring in a group of lupane acids on their cytotoxicity. Bioorganic & Medicinal Chemistry. 2005, 13(19), 5527-5535. ISSN 0968-0896. IF: 2.018. PMID: 16087342
• [18]
  KVASNICA, M., J. ŠAREK, E. KLINOTOVÁ, P. DŽUBÁK a M. HAJDÚCH. Synthesis of phthalates of betulinic acid and betulin with cytotoxic activity. Bioorganic & Medicinal Chemistry. 2005, 13(10), 3447-54. ISSN 0968-0896. IF: 2.018. PMID: 15848757
• [17]
  ŠAREK, J., P. DŽUBÁK, E. KLINOTOVÁ, V. NOSKOVA, V. KŘEČEK, G. KOŘÍNKOVÁ, J.O. THOMSON, A. JANOŠŤÁKOVÁ, S. WANG, S. PARSONS, P.M. FISCHER, N. ZHELEV a M. HAJDÚCH. New lupane derived compounds with Pro-Apoptotic activity in cancer cells: Synthesis and structure-activity relationships. Journal of Medicinal Chemistry. 2003, 46(25), 5402-5415. ISSN 0022-2623. IF: 4.566. PMID: 14640549
• [16]
  NOSKOVA, V., P. DŽUBÁK, G. KUZMINA, A. LUDKOVÁ, D. STEHLÍK, R. TROJANEC, A. JANOŠŤÁKOVÁ, G. KOŘÍNKOVÁ, V. MIHÁL a M. HAJDÚCH. In vitro chemoresistance profile and expression/function of MDR associated proteins in resistant cell lines derived from CCRF-CEM, K562, A549 and MDA MB 231 parental cells. Neoplasma. 2002, 49(6), 418-425. ISSN 0028-2685. IF: 0.637. PMID: 12584592
• [15]
  THOMSON, J.O., P. DŽUBÁK a M. HAJDÚCH. Prostate cancer and food supplement, PC-SPES. Minireview. Neoplazma. 2002, 49(2), 69-74. ISSN 0028-2685. IF: 0.637. PMID: 12088108
• [14]
  KADRIĆ, J., K. MOTYKA, P. DŽUBÁK, M. HAJDÚCH a M. SOURAL. Synthesis, cytotoxic activity, and fluorescence properties of a set of novel 3-hydroxyquinolin-4(1H)-ones. Tetrahedron Letters. 2014, 55(26), 3592-3595. ISSN 0040-4039. IF: 2.379.
• [13]
  POTĚŠIL, J., F. KOPŘIVA, P. DŽUBÁK, M. GODOVA, L. RADOVÁ, J. SROVNAL, V. MIHÁL a M. HAJDÚCH. Expression of multidrug resistance protein 1 and multidrug resistance-associated protein 1 in peripheral blood lymphocytes amongst children and young adults. Central European Journal of Immunology. 2013, 38(4), 518-529. ISSN 1426-3912. IF: 0.358.
• [12]
  PERLÍKOVÁ, P., P. KONEČNÝ, P. NAUŠ, J. SNÁŠEL, I. VOTRUBA, P. DŽUBÁK, I. PICHOVÁ, M. HAJDÚCH a M. HOCEK. 6-Alkyl-, 6-aryl- or 6-hetaryl-7-deazapurine ribonucleosides as inhibitors of human or MTB adenosine kinase and potential antimycobacterial agents. Medicinal Chemistry Communications. 2013, 4(11), 1497-1500. ISSN 2040-2503. IF: 2.626.
• [11]
  CALETKOVÁ, O., A. LÁSIKOVÁ, M. HAJDÚCH, P. DŽUBÁK a T. GRACZA. Synthesis and antitumour activity of varitriol and its analogues. Archive for Organic Chemistry. 2012, 2012(6), 365-383. ISSN 1551-7004. IF: 1.057.
• [10]
  GUCKÝ, T., E. ŘEZNÍČKOVÁ, P. DŽUBÁK, M. HAJDÚCH a V. KRYŠTOF. Synthesis and anticancer activity of some 1,5-diaryl-3-(3,4,5-trihydroxyphenyl)-1H-pyrazolo[4,3-e][1,2,4]triazines. Monatshefte fur Chemie. 2010, 141(6), 709-714. ISSN 0026-9247. IF: 1.356.
• [9]
  JANSA, J., A. LYČKA, Z. PADELKOVA, M. GREPL, P. KONEČNÝ, M. HAJDÚCH a P. DŽUBÁK. New Imidazo[1,2-c]pyrimidin-5(6H)-Ones Derived from Cytosine: Synthesis, Structure, and Cytotoxic Activity. Journal of Heterocyclic Chemistry. 2015, 52, 1382-1389. ISSN 0022-152X. IF: 0.685.
• [8]
  FUNK, P., K. MOTYKA, P. DŽUBÁK, P. ZNOJEK, S. GURSKÁ, J. KUSZ, C. MCMASTER, M. HAJDÚCH a M. SOURAL. Preparation of 2-phenyl-3-hydroxyquinoline- 4(1H)-one-5-carboxamides as potential anticancer and fluorescence agents. RSC Advances. 2015, 5(60), 48861-48867. ISSN 2046-2069. IF: 3.289.
• [7]
  KLECKA, M., L. SLAVĚTÍNSKÁ, E. TLOUŠŤOVÁ, P. DŽUBÁK, M. HAJDÚCH a M. HOCEK. Synthesis and cytostatic activity of 7-arylsulfanyl-7-deazapurine bases and ribonucleosides. MedChemComm. 2015, 6(4), 576-580. ISSN 2040-2503. IF: 2.319.
• [6]
  DŽUBÁK, P., M. HAJDÚCH, D. VYDRA, A. HÚŠŤOVÁ, M. KVASNICA, D. BIEDERMANN, L. MARKOVÁ, M. URBAN a J. ŠAREK. Pharmacological activities of natural triterpenoids and their therapeutic implications. Natural Product Reports. 2006, 23(3), 394-411. ISSN 0265-0568. IF: 7.325.
• [5]
  VEPŘEK, P., M. HAJDÚCH, P. DŽUBÁK, R. KUKLÍK, J. POLÁKOVÁ a K. BEZOUŠKA. Comblike Dendrimers Containing Tn Antigen Modulate Natural Killing and Induce the Production of Tn Specific Antibodies. Journal of Medicinal Chemistry. 2006, 49(21), 6400-6407. ISSN 0022-2623. IF: 4.926.
• [4]
  KONC, J., M. TICHÝ, R. POHL, J. HODEK, P. DŽUBÁK, M. HAJDÚCH a M. HOCEK. Sugar modified pyrimidoij4,5-b]indole nucleosides: synthesis and antiviral activity. MedChemComm. 2017, -, -. ISSN 2040-2503. IF: 2.608.
• [3]
  GUCKÝ, T., I. FRYŠOVÁ, J. SLOUKA, M. HAJDÚCH a P. DŽUBÁK. Cyclocondensation reaction of heterocyclic carbonyl compounds, Part XIII: Synthesis and cytotoxic activity of some 3,7-diaryl-5-(3,4,5-trimethoxyphenyl)pyrazolo[4,3-e][1,2,4]triazines. European Journal of Medicinal Chemistry. 2009, 44(2), 891-900. ISSN 0223-5234. IF: 2.882.
• [2]
  BIEDERMANN, D., J. ŠAREK, J. KLINOT, M. HAJDÚCH a P. DŽUBÁK. Fluorination of betulinines and other triterpenoids with DAST. Synthesis-Stuttgart. 2005, -(7), 1157-1163. ISSN 0039-7881. IF: 2.203.
• [1]
  HOLUB, D., P. FLODROVÁ, T. PIKA, P. FLODR, M. HAJDÚCH a P. DŽUBÁK. Mass Spectrometry Amyloid Typing Is Reproducible across Multiple Organ Sites. Biomed Research International. 2019, -, -. ISSN 2314-6133. IF: 2.583.

Publications (Other Reviewed Journals):

• [9]
  KULTAN, J., V. KOLEK, P. DŽUBÁK, J. VÁCLAVKOVÁ, M. HAJDÚCH a M. SZKORUPA. Možnosti neinvazivní detekce karcinomu plic. Studia Pneumologica et Phthiseologica. 2018, 78(3), 69-75. ISSN 1213-810X.
• [8]
  KLOS, D., M. STASEK, M. LOVECEK, P. SKALICKÝ, R. VRBA, R. AUJESKY, R. HAVLÍK, C. NEORAL, L. VARANASI, M. HAJDÚCH, J. VRBKOVÁ a P. DŽUBÁK. Tumor cells transfer between the patient and laboratory animal as a basic methodological approach to the study of cancerogenesis and identification of biomarkers. Rozhledy v Chirurgii. 2018, 95(12), 432-438. ISSN 0035-9351. PMID: 28 182 438
• [7]
  HOLUB, D., J. HOUDA, M. HAJDÚCH, D. POSPÍŠILOVÁ a P. DŽUBÁK. Stanovení hladiny hepcidinu-25 v séru pomocí SPE_LC_MS/MS metody. Chemagazín. 2016, 5, 8-10. ISSN 1210-7409.
• [6]
  OŽDIAN, T., D. HOLUB, G. RYLOVÁ, J. VÁCLAVKOVÁ, M. HAJDÚCH a P. DŽUBÁK. Porovnání hmotnostně spektrometrických přístupů v proteomickém profilování léčiv. Chemagazín. 2016, 5, 8-11. ISSN 1210-7409.
• [5]
  KONEČNÝ, P., S. GURSKÁ, P. ZNOJEK, E. SCHADICH, M. HAJDÚCH a P. DŽUBÁK. Reprofilování jako úspěšná strategie hledání nových léčiv. Farmakologická léčba. 2015, 4(10/2015), 12-18. ISSN 1805-398X.
• [4]
  SPENEROVA, M., J. SROVNAL, J. POTĚŠIL, M. HAJDÚCH, V. MIHÁL a P. DŽUBÁK. Historie glukokortikoidní terapie v léčbě akutních leukémií u dětí. Česko-slovenská pediatrie. 2014, 69(6), 350-362. ISSN 0069-2328.
• [3]
  HOUDA, J., P. DŽUBÁK, E. KARASKOVA, D. HOLUB, D. VYDRA, D. MLCUCHOVA, M. HAJDÚCH, O. POZLER a D. POSPÍŠILOVÁ. Výskyt anemie a význam měření hladiny hepcidinu metodou ELISA u dětí s nespecifickými střevními záněty. Česko-slovenská pediatrie. 2014, 69(3), 137-147. ISSN 0069-2328.
• [2]
  POSPÍŠILOVÁ, D., J. HOUDA, D. HOLUB, B. LUDÍKOVÁ, R. MOJZIKOVA, P. POSPISILOVA, Z. ŽIDOVÁ, K. KAPRALOVA, M. HORVÁTHOVÁ, M. HAJDÚCH a P. DŽUBÁK. Význam stanovení hladiny hepcidinu v diagnostice vybraných typů anémií v dětském věku. Transfuze a hematologie dnes. 2012, 18(-), 58-65. ISSN 1213-5763.
• [1]
  KUDELA, M., R. PILKA, M. LUBUSKY, P. HEJTMANEK, P. DŽUBÁK a S. BRYCHTOVÁ. Prognostický význam vybraných molekulárně-genetických imunohistochemických markerů a DNA ploidity u karcinomu endometria. Česká gynekologie. 2011, 76(3), 194-199. ISSN 1210-7832.

Book Chapters:

• [4]
  DŽUBÁK, P., M. URBAN a M. HAJDÚCH. Vývoj nových léčiv. In: Molekulární medicína. 1. vyd. Praha: Galén, 2015. Kapitola 11, s. 469-472. ISBN: 978-80-7492-121-6.
• [3]
  CIBIČEK, N., J. VACEK, M. BERANEK, P. DŽUBÁK, Z. HEŘMANOVÁ, P. KOSINA, M. KUBALA, M. NOVÁK, B. PAPOUSKOVA, J. SROVNAL, J. VÁVROVÁ, J. VOSTALOVA, M. ZATLOUKALOVA a H. ŽIVNÁ. Hmotnostní spektrometrie. In: Principy a využití vybraných analytických metod v laboratorní medicíně. 1. vyd. Olomouc: Univerzita Palackého v Olomouci, 2014. Kapitola 2.2, s. 34-40. ISBN: 978-80-244-3951-8.
• [2]
  CIBIČEK, N., J. VACEK, M. BERANEK, P. DŽUBÁK, Z. HEŘMANOVÁ, P. KOSINA, M. KUBALA, M. NOVÁK, B. PAPOUSKOVA, J. SROVNAL, J. VÁVROVÁ, J. VOSTALOVA, M. ZATLOUKALOVA a H. ŽIVNÁ. Elektrochemické metody, (bio)senzory a čipové platformy. In: Principy a využití vybraných analytických metod v laboratorní medicíně. 1. vyd. Olomouc: Univerzita Palackého v Olomouci, 2014. Kapitola 2.3, s. 43-44. ISBN: 978-80-244-3951-8.
• [1]
  ŠAREK, J., M. KVASNICA, M. VLK, M. URBAN, P. DŽUBÁK a M. HAJDÚCH. The Potential of Triterpenoids in the Treatment of Melanoma. In: Research on Melanoma – A Glimpse into Current Directions and Future Trends. 1.vyd. Rijeka: InTech, 2011. Kapitola 7, s. 125-158. ISBN: 978-953-307-293-7.

Books:

• [1]
  DRABEK, J., J. BERKOVCOVA, P. DŽUBAK, M. HAJDUCH, M. KHOYLOU, V. KOUDELAKOVA, J. SROVNAL, M. STAŇKOVA a R. TROJANEC. Detekce nádorových biomarkerů v molekulárně biologické laboratoři. 1. vyd. Olomouc: Univerzita Palackého v Olomouci, 2012. 144 s. ISBN: 978-80-244-3002-7.