Džubák Petr M.D., Ph.D.

Džubák Petr M.D., Ph.D.'s picture
Phone: +420 585632150, +420 604851158
Curriculum Vitae: download
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Scientist and pediatrician involved in molecular and translational medicine (disease area oncology and infectious diseases), leader of research program Chemical Biology and Experimental Therapeutics at IMTM. Actively participated in the research of more than 20 national and international projects; member of advisory board of Cancer Research Foundation „Rakovina ve veřejná“, co-founder of spin-off company focused on manufacturing of molecular diagnostics. Published more than >50 papers and books/chapters, >800 SCI citations, H-index 15, Prix de Pharmacie 2007 Ambassade de France – Sanofi-aventis, Premier Prix. 
 
Specialties: 

Molecular and translational medicine 
Oncology 
Drug research and development, MOA, epigenetics, drug resistance  


Publications (Impact Factor Journals):

  • [76]
    JURÁŠEK, M., M. CERNOHORSKA, J. ŘEHULKA, V. SPIWOK, T. SULIMENKO, E. DRABEROVA, M. DARMOSTUK, S. GURSKÁ, I. FRYDRYCH, R. BURIÁNOVÁ, T. RUML, M. HAJDÚCH, P. BARTŮNĚK, P. DRABER, P. DŽUBÁK, P. DRAŠAR a D. SEDLÁK. Estradiol Dimer Inhibits Tubulin Polymerization and Microtubule Dynamics. The Journal of Steroid Biochemistry and Molecular Biology. 2018, -, -. ISSN 0960-0760. IF: 4.561. PMID: 29803726
  • [75]
    MRAZKOVA, B., R. DZIJAK, T. IMRICHOVA, L. KYJACOVA, P. BARATH, P. DŽUBÁK, D. HOLUB, M. HAJDÚCH, Z. NAHACKA, L. ANDERA, P. HOLICEK, P. VASICOVA a O. SAPEGA. Induction, regulation and roles of neural adhesion molecule L1CAM in cellular senescence. Aging. 2018, 10(3), 432-462. ISSN 1945-4589. IF: 4.867. PMID: 29615539
  • [74]
    BÜRGLOVÁ, K., G. RYLOVÁ, A. MARKOS, H. PŘICHYSTALOVÁ, M. SOURAL, M. PETRÁČEK, M. MEDVEDÍKOVÁ, G. TEJRAL, B. SOPKO, P. HRADIL, P. DŽUBÁK, M. HAJDÚCH a J. HLAVÁČ. Identification of Eukaryotic Translation Elongation Factor 1-α 1 Gamendazole-Binding Site for Binding of 3-Hydroxy-4(1 H)-quinolinones as Novel Ligands with Anticancer Activity. Journal of Medicinal Chemistry. 2018, -, -. ISSN 0022-2623. IF: 6.259. PMID: 29498519
  • [73]
    FLODROVÁ, P., P. FLODR, T. PIKA, J. VYMETAL, D. HOLUB, P. DŽUBÁK, M. HAJDÚCH a V. SCUDLA. Cardiac amyloidosis: from clinical suspicion to morphological diagnosis. Pathology. 2018, -, -. ISSN 0031-3025. IF: 2.709. PMID: 29448998
  • [72]
    POKORNÝ, J., S. KRAJČOVIČOVÁ, M. HAJDÚCH, M. HOLOUBEK, S. GURSKÁ, P. DŽUBÁK, T. VOLNÁ, I. POPA a M. URBAN. Triterpenic azines, a new class of compounds with selective cytotoxicity to leukemia cells CCRF-CEM. Future Medicinal Chemistry. 2018, 10(5), 483-491. ISSN 1756-8919. IF: 3.566. PMID: 29424548
  • [71]
    KRAJČOVIČOVÁ, S., J. STANKOVÁ, P. DŽUBÁK, M. HAJDÚCH, M. SOURAL a M. URBAN. A Synthetic Approach for the Rapid Preparation of BODIPY Conjugates and their use in Imaging of Cellular Drug Uptake and Distribution. Chemistry- A European Journal. 2018, 24(19), 4957-4966. ISSN 0947-6539. IF: 5.317. PMID: 29411907
  • [70]
    ŘEHULKA, J., N. ANNADURAI, I. FRYDRYCH, P. DŽUBÁK, M. MILLER, M. HAJDÚCH a V. DAS. Peloruside A-Induced Cell Death in Hypoxia Is p53 Dependent in HCT116 Colorectal Cancer Cells. Journal of Natural Products. 2018, -, -. ISSN 0163-3864. IF: 3.281. PMID: 29400463
  • [69]
    SESTAK, S., M. BELLA, T. KLUNDA, S. GURSKÁ, P. DŽUBÁK, F. WÖLS, I. WILSON, V. SLADEK, M. HAJDÚCH, M. POLÁKOVÁ a J. KONA. N-Benzyl Substitution of Polyhydroxypyrrolidines: The Way to Selective Inhibitors of Golgi α-Mannosidase II. ChemMedChem. 2018, 13(4), 373-383. ISSN 1860-7179. IF: 3.225. PMID: 29323461
  • [68]
    ŠKROTT, Z., M. MISTRÍK, K. ANDERSEN, S. FRIIS, D. MAJERA, J. GURSKÝ, T. OŽDIAN, J. BARTKOVA, Z. TURI, P. MOUDRÝ, M. KRAUS, M. MEDVEDÍKOVÁ, J. VÁCLAVKOVÁ, P. DŽUBÁK, I. VROBEL, P. POUCKOVA, J. SEDLACEK, A. MIKLOVICOVA, A. KUTT, J. MATTOVA, C. DRIESSEN, Q. DOU, J. OLSEN, M. HAJDÚCH, B. CVEK, R. DESHAIES a J. BÁRTEK. Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4. Nature. 2017, 552(7684), 194-199. ISSN 0028-0836. IF: 40.137. PMID: 29211715
  • [67]
    CAMATEROS, P., C. KANAGARATHAM, L. NAJDEKR, D. HOLUB, J. VRBKOVÁ, L. COTE, J. FOURNIER, J. GOURDON, D. CREERY, R. OLIVENSTEIN, F. KOPŘIVA, T. ADAM, D. FRIEDECKÝ, P. DŽUBÁK, M. HAJDÚCH a D. RADZIOCH. TLR 7/8 Ligand, S28463, Suppresses Ascaris Suum Induced Allergic Asthma in Nonhuman Primates. American Journal of Respiratory Cell and Molecular Biology. 2017, 58(1), 55-65. ISSN 1044-1549. IF: 4.100. PMID: 28850259
  • [66]
    MOJZIKOVA, R., P. KOŘALKOVÁ, D. HOLUB, Z. SAXOVA, D. POSPÍŠILOVÁ, D. PROCHAZKOVA, P. DŽUBÁK, M. HORVÁTHOVÁ a V. DIVOKÝ. Two novel mutations (p.(Ser160Pro) and p.(Arg472Cys)) causing glucose-6-phosphate isomerase deficiency are associated with erythroid dysplasia and inappropriately suppressed hepcidin. Blood cells, molecules & diseases. 2017, 69, 23-29. ISSN 1079-9796. IF: 1.882. PMID: 28803808
  • [65]
    ANNADURAI, N., K. AGRAWAL, P. DŽUBÁK, M. HAJDÚCH a V. DAS. Microtubule affinity-regulating kinases are potential druggable targets for Alzheimer's disease. Cellular and Molecular Life Sciences. 2017, 74(22), 4159-4169. ISSN 1420-682X. IF: 5.788. PMID: 28634681
  • [64]
    OŽDIAN, T., D. HOLUB, Z. MACEČKOVÁ, L. VARANASI, G. RYLOVÁ, J. ŘEHULKA, J. VÁCLAVKOVÁ, H. SLAVÍK, P. MOUDRÝ, P. ZNOJEK, J. STANKOVÁ, J.B. DE SANCTIS, M. HAJDÚCH a P. DŽUBÁK. Proteomic profiling reveals DNA damage, nucleolar and ribosomal stress are the main responses to oxaliplatin treatment in cancer cells. Journal of Proteomics. 2017, 162, 73-85. ISSN 1874-3919 . IF: 3.867. PMID: 28478306
  • [63]
    PAJTAS, D., K. KONYA, A. KISS-SZIKSZAI, P. DŽUBÁK, Z. PETHO, Z. VARGA, G. PANYI a T. PATONAY. Optimization of the Synthesis of Flavone-Amino Acid and Flavone-Dipeptide Hybrids via Buchwald-Hartwig Reaction. Journal of Organic Chemistry. 2017, 82(5), 4578-4587. ISSN 0022-3263. IF: 4.849. PMID: 28441016
  • [62]
    ŘEHULKA, J., N. ANNADURAI, I. FRYDRYCH, P. ZNOJEK, P. DŽUBÁK, P. NORTHCOTE, J.H. MILLER, M. HAJDÚCH a V. DAS. Cellular effects of the microtubule-targeting agent peloruside A in hypoxia-conditioned colorectal carcinoma cells. Biochimica et Biophysica Acta. 2017, 17, 30124-1. ISSN 0304-4165. IF: 5.083. PMID: 28366502
  • [61]
    DAS, V., T. FÜRST, S. GURSKÁ, P. DŽUBÁK a M. HAJDÚCH. Evaporation-reducing Culture Condition Increases the Reproducibility of Multicellular Spheroid Formation in Microtiter Plates. Journal of Visualized Experiments. 2017, 121, doi: 10.3791/55403. ISSN 1940-087X. IF: 1.113. PMID: 28362402
  • [60]
    TICHÝ, M., S. SMOLEN, E. TLOUŠŤOVÁ, R. POHL, T. OŽDIAN, K. HEJTMÁNKOVÁ, B. LIŠKOVÁ, S. GURSKÁ, P. DŽUBÁK, M. HAJDÚCH a M. HOCEK. Synthesis and Cytostatic and Antiviral Profiling of Thieno-Fused 7-Deazapurine Ribonucleosides. Journal of Medicinal Chemistry. 2017, 60(6), 2411-2424. ISSN 0022-2623. IF: 5.589. PMID: 28221790
  • [59]
    ŠIDOVÁ, V., P. ZOUFALÝ, J. POKORNÝ, P. DŽUBÁK, M. HAJDÚCH, I. POPA a M. URBAN. Cytotoxic conjugates of betulinic acid and substituted triazoles prepared by Huisgen Cycloaddition from 30-azidoderivatives. PLOS One. 2017, 12(2), e0171621. ISSN 1932-6203 . IF: 3.057. PMID: 28158265
  • [58]
    VOLLER, J., T. BERES, M. ZATLOUKAL, P. KAMINSKI, P. NIEMANN, K. DOLEZAL, P. DŽUBÁK, M. HAJDÚCH a M. STRNAD. The natural cytokinin 2OH3MeOBAR induces cell death by a mechanism that is different from that of the "classical" cytokinin ribosides. Phytochemistry. 2017, 136, 156-164. ISSN 0031-9422 . IF: 2.779. PMID: 28153445
  • [57]
    BORKOVÁ, L., R. ADÁMEK, P. KALINA, P. DRAŠAR, P. DŽUBÁK, S. GURSKÁ, J. ŘEHULKA, M. HAJDÚCH, M. URBAN a J. ŠAREK. Synthesis and Cytotoxic Activity of Triterpenoid Thiazoles Derived from Allobetulin, Methyl Betulonate, Methyl Oleanonate, and Oleanonic Acid. ChemMedChem. 2017, 12(5), 390-398. ISSN 1860-7179 . IF: 2.980. PMID: 28084676
  • [56]
    AGRAWAL, K., V. DAS, M. OTMAR, M. KRECMEROVA, P. DŽUBÁK a M. HAJDÚCH. Cell-based DNA demethylation detection system for screening of epigenetic drugs in 2D, 3D, and xenograft models. Cytometry A. 2016, -, -. ISSN 1552-4922 . IF: 3.222. PMID: 27911980
  • [55]
    SCHADICH, E., P. DŽUBÁK a M. HAJDÚCH. Role of Salmonella Typhi Vi Antigen and Secretory Systems on Immune Response. Current Pharmaceutical Design. 2016, 22(41), 6251-6260. ISSN 1381-6128. IF: 2.611. PMID: 27573929
  • [54]
    JURÁŠEK, M., P. DŽUBÁK, S. RIMPELOVA, D. SEDLÁK, P. KONEČNÝ, I. FRYDRYCH, S. GURSKÁ, M. HAJDÚCH, K. BOGDANOVÁ, M. KOLÁŘ, T. MÜLLER, E. KMONICKOVA, T. RUML, J. HARMATHA a P. DRAŠAR. Trilobolide-steroid hybrids: Synthesis, cytotoxic and antimycobacterial activity. Steroids. 2017, 117(2017), 97-104. ISSN 0039-128X. IF: 2.513. PMID: 27543674
  • [53]
    ŠIMKOVÁ, D., G. KHARAISHVILI, G. KOŘÍNKOVÁ, T. OŽDIAN, T. SUCHANKOVA-KLEPLOVA, T. SOUKUP, M. KŘUPKA, A. GALANDÁKOVÁ, P. DŽUBÁK, M. JANÍKOVÁ, J. NAVRATIL, Z. KAHOUNOVA, K. SOUCEK a J. BOUCHAL. The dual role of asporin in breast cancer progression. Oncotarget. 2016, 7(32), 52045-52060. ISSN 1949-2553 . IF: 5.168. PMID: 27409832
  • [52]
    BORKOVÁ, L., S. GURSKÁ, P. DŽUBÁK, R. BURIÁNOVÁ, M. HAJDÚCH, J. ŠAREK, I. POPA a M. URBAN. Lupane and 18α-oleanane derivatives substituted in the position 2, their cytotoxicity and influence on cancer cells. European Journal of Medicinal Chemistry. 2016, 121, 120-131. ISSN 0223-5234 . IF: 4.519. PMID: 27236068
  • [51]
    DAS, V., T. FÜRST, S. GURSKÁ, P. DŽUBÁK a M. HAJDÚCH. Reproducibility of Uniform Spheroid Formation in 384-Well Plates: The Effect of Medium Evaporation. Journal of Biomolecular Screening. 2016, 21(9), 923-30. ISSN 1087-0571 . IF: 2.444. PMID: 27226477
  • [50]
    HRUBY, M., K. AGRAWAL, O. POLICIANOVA, J. BRUS, J. SKOPAL, P. SVEC, M. OTMAR, P. DŽUBÁK, P. STEPANEK a M. HAJDÚCH. Biodegradable system for drug delivery of hydrolytically labile azanucleoside drugs. Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czech Republic. 2016, 160(2), 222-230. ISSN 1213-8118 . IF: 0.894. PMID: 27003313
  • [49]
    SCHADICH, E., J. HLAVÁČ, T. VOLNÁ, L. VARANASI, M. HAJDÚCH a P. DŽUBÁK. Effects of Ginger Phenylpropanoids and Quercetin on Nrf2-ARE Pathway in Human BJ Fibroblasts and HaCaT Keratinocytes. BioMed Research International . 2016, 2016, 2016:2173275. ISSN 2314-6133. IF: 2.476. PMID: 26942188
  • [48]
    PERLÍKOVÁ, P., G. RYLOVÁ, P. NAUŠ, T. ELBERT, E. TLOUŠŤOVÁ, A. BOURDERIOUX, L. SLAVĚTÍNSKÁ, K. MOTYKA, D. DOLEŽAL, P. ZNOJEK, A. NOVÁ, M. HARVANOVÁ, P. DŽUBÁK, M. ŠILLER, J. HLAVÁČ, M. HAJDÚCH a M. HOCEK. 7-(2-Thienyl)-7-deazaadenosine (AB61), a new potent nucleoside cytostatic with a complex mode of action. Molecular Cancer Therapeutics. 2016, 15(5), 922-937. ISSN 1535-7163 . IF: 5.764. PMID: 26819331
  • [47]
    NAUŠ, P., O. CALETKOVÁ, P. PERLÍKOVÁ, L. SLAVĚTÍNSKÁ, E. TLOUŠŤOVÁ, J. HODEK, J. WEBER, P. DŽUBÁK, M. HAJDÚCH a M. HOCEK. Synthesis and biological profiling of 6-or 7-(het)aryl-7-deazapurine 4 '-C-methylribonucleosides. Bioorganic and Medicinal Chemistry. 2015, 23(23), 7422-7438. ISSN 0968-0896 . IF: 2.923. PMID: 26558518
  • [46]
    SOURAL, M., J. HODOŇ, N.J. DICKINSON, V. ŠIDOVÁ, S. GURSKÁ, P. DŽUBÁK, M. HAJDÚCH, J. ŠAREK a M. URBAN. Preparation of Conjugates of Cytotoxic Lupane Triterpenes with Biotin. Bioconjugate Chemistry. 2015, 26(12), 2563-70. ISSN 1043-1802. IF: 4.818. PMID: 26537839
  • [45]
    BORKOVÁ, L., L. JASILKOVA, J. ŘEHULKA, K. FRISONSOVA, M. URBAN, I. FRYDRYCH, I. POPA, M. HAJDÚCH, N.J. DICKINSON, M. VLK, P. DŽUBÁK a J. ŠAREK. Synthesis of cytotoxic 2,2-difluoroderivatives of dihydrobetulinic acid and allobetulin and study of their impact on cancer cells. European Journal of Medicinal Chemistry. 2015, 96(-), 482-490. ISSN 0223-5234. IF: 3.902. PMID: 25942059
  • [44]
    KAPLANEK, R., M. JAKUBEK, J. RAK, Z. KEJIK, M. HAVLIK, B.. DOLENSKY, I. FRYDRYCH, M. HAJDÚCH, M. KOLÁŘ, K. BOGDANOVÁ, J. KRALOVA, P. DŽUBÁK a V. KRAL. Caffeine-hydrazones as anticancer agents with pronounced selectivity toward T-lymphoblastic leukaemia cells. Bioorganic Chemistry. 2015, 60(-), 19-29. ISSN 0045-2068. IF: 2.252. PMID: 25912310
  • [43]
    MALNUIT, V., L. SLAVĚTÍNSKÁ, P. NAUŠ, P. DŽUBÁK, M. HAJDÚCH, J. STOLAŘÍKOVÁ, J. SNÁŠEL, I. PICHOVÁ a M. HOCEK. 2-Substituted 6-(Het)aryl-7-deazapurine Ribonucleosides: Synthesis, Inhibition of Adenosine Kinases, and Antimycobacterial Activity. ChemMedChem. 2015, 10(6), 1079-1093. ISSN 1860-7179. IF: 2.980. PMID: 25882678
  • [42]
    KAPLANEK, R., M. HAVLIK, B.. DOLENSKY, J. RAK, P. DŽUBÁK, P. KONEČNÝ, M. HAJDÚCH, J. KRALOVA a V. KRAL. Synthesis and biological activity evaluation of hydrazone derivatives based on a Troger's base skeleton. Bioorganic and Medicinal Chemistry. 2015, 23(7), 1651-1659. ISSN 0968-0896. IF: 2.923. PMID: 25737088
  • [41]
    BRIZA, T., J. KRALOVA, B.. DOLENSKY, S. RIMPELOVA, Z. KEJIK, T. RUML, M. HAJDÚCH, P. DŽUBÁK, I. MIKULA, P. MARTASEK, P. POUCKOVA a V. KRAL. Striking antitumor activity of a methinium system with incorporated quinoxaline unit obtained by spontaneous cyclization. Chembiochem. 2015, 16(4), 555-558. ISSN 1439-4227. IF: 2.850. PMID: 25630657
  • [40]
    RYLOVÁ, G., T. OŽDIAN, L. VARANASI, M. SOURAL, J. HLAVÁČ, D. HOLUB, P. DŽUBÁK a M. HAJDÚCH. Affinity-Based Methods in Drug-Target Discovery. Current Drug Targets. 2015, 16(1), 60-76. ISSN 1389-4501. IF: 3.029. PMID: 25410410
  • [39]
    SNÁŠEL, J., P. NAUŠ, J. DOSTÁL, A. HNÍZDA, J. FANFRLÍK, J. BRYNDA, A. BOURDERIOUX, M. DUŠEK, H. DVOŘÁKOVÁ, J. STOLAŘÍKOVÁ, H. ZÁBRANSKÁ, R. POHL, P. KONEČNÝ, P. DŽUBÁK, I. VOTRUBA, M. HAJDÚCH, P. ŘEZÁČOVÁ, V. VEVERKA, M. HOCEK a I. PICHOVÁ. Structural Basis for Inhibition of Mycobacterial and Human Adenosine Kinase by 7-Substituted 7-(Het)aryl-7-deazaadenine Ribonucleosides. Journal of Medicinal Chemistry. 2014, 57(20), 8268-8279. ISSN 0022-2623. IF: 5.447. PMID: 25259627
  • [38]
    POSPÍŠILOVÁ, D., D. HOLUB, Z. ŽIDOVÁ, L. SULOVSKÁ, J. HOUDA, V. MIHÁL, I. HADAČOVÁ, L. RADOVÁ, P. DŽUBÁK, M. HAJDÚCH, V. DIVOKÝ a M. HORVÁTHOVÁ. Hepcidin levels in Diamond-Blackfan anemia reflect erythropoietic activity and transfusion dependency. Haematologica. 2014, 99(7), e118-121. ISSN 0390-6078. IF: 5.814. PMID: 24727814
  • [37]
    NAUŠ, P., O. CALETKOVÁ, P. KONEČNÝ, P. DŽUBÁK, K. BOGDANOVÁ, M. KOLÁŘ, J. VRBKOVÁ, L. SLAVĚTÍNSKÁ, E. TLOUŠŤOVÁ, P. PERLÍKOVÁ, M. HAJDÚCH a M. HOCEK. Synthesis, cytostatic, antimicrobial, and anti-HCV activity of 6-substituted 7-(het)aryl-7-deazapurine ribonucleosides. Journal of Medicinal Chemistry. 2014, 57(3), 1097-1110. ISSN 0022-2623. IF: 5.447. PMID: 24397620
  • [36]
    TYLEČKOVÁ, J., R. HRABAKOVA, K. MAIRYCHOVÁ, P. HALADA, L. RADOVÁ, P. DŽUBÁK, M. HAJDÚCH, S.J. GADHER a H. KOVÁŘOVÁ. Cancer Cell response to Anthracyclines Effects: Mysteries of the Hidden Proteins Associated with These Drugs. International Journal of Molecular Sciences. 2012, 2012(13), 15536-15564. ISSN 1422-0067. IF: 2.464. PMID: 23443080
  • [35]
    JURÁŠEK, M., P. DŽUBÁK, D. SEDLÁK, H. DVOŘÁKOVÁ, M. HAJDÚCH, P. BARTŮNĚK a P. DRAŠAR. Preparation, preliminary screening of new types of steroid conjugates and their activities on steroid receptors. Steroids. 2013, 78(-), 356-361. ISSN 0039-128X. IF: 2.716. PMID: 23291595
  • [34]
    SPENEROVA, M., P. DŽUBÁK, J. SROVNAL, L. RADOVÁ, R. BURIÁNOVÁ, P. KONEČNÝ, S. ŠÁLKOVÁ, Z. NOVÁK, D. POSPÍŠILOVÁ, J. STARÝ, B.. BLAZEK, J. HAK, T. VOTAVA, P. TIMR, E. KAISEROVA, E. BUBANSKA, V. MIHÁL a M. HAJDÚCH. Combination of prednisolone and low dosed dexamethasone exhibits greater in vitro antileukemic activity than equiactive dose of prednisolone and overcomes prednisolone drug resistence in acute childhood lymphoblastic leukemia. Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czech Republic. 2014, 158(3), 422-427. ISSN 1213-8118. IF: 1.200. PMID: 23128824
  • [33]
    KUDELA, M., R. PILKA, M. LUBUSKY, P. HEJTMANEK, P. DŽUBÁK a S. BRYCHTOVÁ. Prognostic importance of selected molecular immunohistochemical markers and DNA ploidy in endometrial cancer. European Journal of Gynaecological Oncology. 2012, 33(2), 159-163. ISSN 0392-2936. IF: 0.577. PMID: 22611955
  • [32]
    URBAN, M., M. VLK, P. DŽUBÁK, M. HAJDÚCH a J. ŠAREK. Cytotoxic heterocyclic triterpenoids derived from betulin and betulinic acid. Bioorganic & Medicinal Chemistry. 2012, 20(11), 3666-3674. ISSN 0968-0896. IF: 2.903. PMID: 22551630
  • [31]
    KOLLAREDDY, M., D. ZHELEVA, P. DŽUBÁK, P.S. BRAHMKSHATRIYA, M. LEPSIK a M. HAJDÚCH. Aurora kinase inhibitors: Progress towards the clinic. Investigational New Drugs. 2012, 30(6), 2411-2432. ISSN 0167-6997. IF: 3.498. PMID: 22350019
  • [30]
    BRULÍKOVÁ, L., P. DŽUBÁK, M. HAJDÚCH a J. HLAVÁČ. Synthesis of Various 5-Alkoxymethyluracil Analogues and Structure-Cytotoxic Activity Relationship Study. Carbohydrate Research. 2011, 346(14), 2136-2144. ISSN 0008-6215. IF: 2.332. PMID: 21864833
  • [29]
    BOURDERIOUX, A., P. NAUŠ, P. PERLÍKOVÁ, R. POHL, I. PICHOVÁ, I. VOTRUBA, P. DŽUBÁK, P. KONEČNÝ, M. HAJDÚCH, K.M. STRAY, T. WANG, A.S. RAY, J.Y. FENG, G. BIRKUS, T. CIHLÁŘ a M. HOCEK. Synthesis and Significant Cytostatic Activity of 7-Hetaryl-7-deazaadenosines. Journal of Medicinal Chemistry. 2011, 54(15), 5498-5507. ISSN 0022-2623. IF: 5.248. PMID: 21711054
  • [28]
    SOURAL, M., J. HLAVÁČ, P. FUNK, P. DŽUBÁK a M. HAJDÚCH. 2-Phenylsubstituted-3-Hydroxyquinolin-4(1H)-one-Carboxamides: Structure-Cytotoxic Activity Relationship Study. ACS Combinatorial Science. 2011, 13(1), 39-44. ISSN 1520-4766. IF: 3.450. PMID: 21247123
  • [27]
    STROHALM, M., P. NOVAK, P. POMPACH, P. DŽUBÁK, P. MAN, D. KAVAN, M. WITT, M. HAJDÚCH a V. HAVLICEK. Utilization of high-accuracy FTICR-MS data in protein quantitation experiments. Journal of Mass Spectrometry. 2009, 44(11), 1565-70. ISSN 1076-5174. IF: 2.940. PMID: 19536796
  • [26]
    KOPŘIVA, F., P. DŽUBÁK, J. POTĚŠIL a M. HAJDÚCH. The anti-inflammatory effects of inhaled corticosteroids versus anti-leukotrienes on the lymphocyte P-glycoprotein (PGP) expression in asthmatic children. Journal of Astma. 2009, 46(4), 366-370. ISSN 0277-0903. IF: 1.330. PMID: 19484671
  • [25]
    PAPRSKÁŘOVÁ, M., V. KRYŠTOF, R. JORDA, P. DŽUBÁK, M. HAJDÚCH, J. WESIERSKA-GADEK a M. STRNAD. Functional p53 in cells contributes to the anticancer effect of the cyclin-dependent kinase inhibitor roscovitine. Journal of Cellular Biochemistry. 2009, 107(3), 428-437. ISSN 0730-2312. IF: 1.330. PMID: 19308936
  • [24]
    SPÁČILOVÁ, L., P. DŽUBÁK, M. HAJDÚCH, S. KŘUPKOVÁ, P. HRADIL a J. HLAVÁČ. Synthesis and cytotoxic activity of various 5-[alkoxy-(4-nitro-phenyl]-methyl]-uracils in their racemic form. Biorganic & Medicinal Chemistry Letters. 2007, 17(23), 6647-6650. ISSN 0960-894X. IF: 2.538. PMID: 17935983
  • [23]
    KRYŠTOF, V., P. CANKAR, I. FRYŠOVÁ, J. SLOUKA, G. KONTOPIDIS, P. DŽUBÁK, M. HAJDÚCH, J. SROVNAL, W.F. DE AZAVEDO, M. ORSÁG, M. PAPRSKÁŘOVÁ, J. ROLČÍK, A. LÁTR, P.M. FISCHER a M. STRNAD. 4-Arylazo-3,5-diamino-1H-pyrazole CDK Inhibitors: SAR Study, Crystal Structure in Complex with CDK2, Selectivity, and Cellular Effects. Journal of Medicinal Chemistry. 2006, 49(22), 6500-6509. ISSN 0022-2623. IF: 4.926. PMID: 17064068
  • [22]
    VEPŘEK, P., M. HAJDÚCH, P. DŽUBÁK, R. KUKLÍK, J. POLÁKOVÁ a K. BEZOUŠKA. Comblike Dendrimers Containing Tn Antigen Modulate Natural Killing and Induce the Production of Tn Specific Antibodies. Journal of Medicinal Chemistry. 2006, 49(21), 6400-6407. ISSN 0022-2623. IF: 4.926. PMID: 17034145
  • [21]
    DŽUBÁK, P., M. HAJDÚCH, D. VYDRA, A. HÚŠŤOVÁ, M. KVASNICA, D. BIEDERMANN, L. MARKOVÁ, M. URBAN a J. ŠAREK. Pharmacological activities of natural triterpenoids and their therapeutic implications. Natural Product Reports. 2006, 23(3), 394-411. ISSN 0265-0568. IF: 7.325. PMID: 16741586
  • [20]
    DŽUBÁK, P., M. HAJDÚCH, R. GAZAK, A. SVOBODOVÁ, J. PSOTOVÁ, D. WALTEROVÁ, P. SEDMERA a V. KREN. New derivatives of silybin and 2,3-dehydrosilybin and their cytotoxic and P-glycoprotein modulatory activity. Bioorganic & Medicinal Chemistry. 2006, 14(11), 3793-3810. ISSN 0968-0896. IF: 2.286. PMID: 16466920
  • [19]
    URBAN, M., J. ŠAREK, I. TIŠLEROVÁ, P. DŽUBÁK a M. HAJDÚCH. Influence of esterification and modification of A-ring in a group of lupane acids on their cytotoxicity. Bioorganic & Medicinal Chemistry. 2005, 13(19), 5527-5535. ISSN 0968-0896. IF: 2.018. PMID: 16087342
  • [18]
    KVASNICA, M., J. ŠAREK, E. KLINOTOVÁ, P. DŽUBÁK a M. HAJDÚCH. Synthesis of phthalates of betulinic acid and betulin with cytotoxic activity. Bioorganic & Medicinal Chemistry. 2005, 13(10), 3447-54. ISSN 0968-0896. IF: 2.018. PMID: 15848757
  • [17]
    ŠAREK, J., P. DŽUBÁK, E. KLINOTOVÁ, V. NOSKOVA, V. KŘEČEK, G. KOŘÍNKOVÁ, J.O. THOMSON, A. JANOŠŤÁKOVÁ, S. WANG, S. PARSONS, P.M. FISCHER, N. ZHELEV a M. HAJDÚCH. New lupane derived compounds with Pro-Apoptotic activity in cancer cells: Synthesis and structure-activity relationships. Journal of Medicinal Chemistry. 2003, 46(25), 5402-5415. ISSN 0022-2623. IF: 4.566. PMID: 14640549
  • [16]
    NOSKOVA, V., P. DŽUBÁK, G. KUZMINA, A. LUDKOVÁ, D. STEHLÍK, R. TROJANEC, A. JANOŠŤÁKOVÁ, G. KOŘÍNKOVÁ, V. MIHÁL a M. HAJDÚCH. In vitro chemoresistance profile and expression/function of MDR associated proteins in resistant cell lines derived from CCRF-CEM, K562, A549 and MDA MB 231 parental cells. Neoplasma. 2002, 49(6), 418-425. ISSN 0028-2685. IF: 0.637. PMID: 12584592
  • [15]
    THOMSON, J.O., P. DŽUBÁK a M. HAJDÚCH. Prostate cancer and food supplement, PC-SPES. Minireview. Neoplazma. 2002, 49(2), 69-74. ISSN 0028-2685. IF: 0.637. PMID: 12088108
  • [14]
    KADRIĆ, J., K. MOTYKA, P. DŽUBÁK, M. HAJDÚCH a M. SOURAL. Synthesis, cytotoxic activity, and fluorescence properties of a set of novel 3-hydroxyquinolin-4(1H)-ones. Tetrahedron Letters. 2014, 55(26), 3592-3595. ISSN 0040-4039. IF: 2.379.
  • [13]
    POTĚŠIL, J., F. KOPŘIVA, P. DŽUBÁK, M. GODOVA, L. RADOVÁ, J. SROVNAL, V. MIHÁL a M. HAJDÚCH. Expression of multidrug resistance protein 1 and multidrug resistance-associated protein 1 in peripheral blood lymphocytes amongst children and young adults. Central European Journal of Immunology. 2013, 38(4), 518-529. ISSN 1426-3912. IF: 0.358.
  • [12]
    PERLÍKOVÁ, P., P. KONEČNÝ, P. NAUŠ, J. SNÁŠEL, I. VOTRUBA, P. DŽUBÁK, I. PICHOVÁ, M. HAJDÚCH a M. HOCEK. 6-Alkyl-, 6-aryl- or 6-hetaryl-7-deazapurine ribonucleosides as inhibitors of human or MTB adenosine kinase and potential antimycobacterial agents. Medicinal Chemistry Communications. 2013, 4(11), 1497-1500. ISSN 2040-2503. IF: 2.626.
  • [11]
    CALETKOVÁ, O., A. LÁSIKOVÁ, M. HAJDÚCH, P. DŽUBÁK a T. GRACZA. Synthesis and antitumour activity of varitriol and its analogues. Archive for Organic Chemistry. 2012, 2012(6), 365-383. ISSN 1551-7004. IF: 1.057.
  • [10]
    GUCKÝ, T., E. ŘEZNÍČKOVÁ, P. DŽUBÁK, M. HAJDÚCH a V. KRYŠTOF. Synthesis and anticancer activity of some 1,5-diaryl-3-(3,4,5-trihydroxyphenyl)-1H-pyrazolo[4,3-e][1,2,4]triazines. Monatshefte fur Chemie. 2010, 141(6), 709-714. ISSN 0026-9247. IF: 1.356.
  • [9]
    JANSA, J., A. LYČKA, Z. PADELKOVA, M. GREPL, P. KONEČNÝ, M. HAJDÚCH a P. DŽUBÁK. New Imidazo[1,2-c]pyrimidin-5(6H)-Ones Derived from Cytosine: Synthesis, Structure, and Cytotoxic Activity. Journal of Heterocyclic Chemistry. 2015, 52, 1382-1389. ISSN 0022-152X. IF: 0.685.
  • [8]
    FUNK, P., K. MOTYKA, P. DŽUBÁK, P. ZNOJEK, S. GURSKÁ, J. KUSZ, C. MCMASTER, M. HAJDÚCH a M. SOURAL. Preparation of 2-phenyl-3-hydroxyquinoline- 4(1H)-one-5-carboxamides as potential anticancer and fluorescence agents. RSC Advances. 2015, 5(60), 48861-48867. ISSN 2046-2069. IF: 3.289.
  • [7]
    KLECKA, M., L. SLAVĚTÍNSKÁ, E. TLOUŠŤOVÁ, P. DŽUBÁK, M. HAJDÚCH a M. HOCEK. Synthesis and cytostatic activity of 7-arylsulfanyl-7-deazapurine bases and ribonucleosides. MedChemComm. 2015, 6(4), 576-580. ISSN 2040-2503. IF: 2.319.
  • [6]
    DŽUBÁK, P., M. HAJDÚCH, D. VYDRA, A. HÚŠŤOVÁ, M. KVASNICA, D. BIEDERMANN, L. MARKOVÁ, M. URBAN a J. ŠAREK. Pharmacological activities of natural triterpenoids and their therapeutic implications. Natural Product Reports. 2006, 23, 394-411. ISSN 0265-0568. IF: 7.325.
  • [5]
    VEPŘEK, P., M. HAJDÚCH, P. DŽUBÁK, R. KUKLÍK, J. POLÁKOVÁ a K. BEZOUŠKA. Comblike Dendrimers Containing Tn Antigen Modulate Natural Killing and Induce the Production of Tn Specific Antibodies. Journal of Medicinal Chemistry. 2006, 49(21), 6400-6407. ISSN 0022-2623. IF: 4.926.
  • [4]
    KONC, J., M. TICHÝ, R. POHL, J. HODEK, P. DŽUBÁK, M. HAJDÚCH a M. HOCEK. Sugar modified pyrimidoij4,5-b]indole nucleosides: synthesis and antiviral activity. MedChemComm. 2017, -, -. ISSN 2040-2503. IF: 2.608.
  • [3]
    GUCKÝ, T., I. FRYŠOVÁ, J. SLOUKA, M. HAJDÚCH a P. DŽUBÁK. Cyclocondensation reaction of heterocyclic carbonyl compounds, Part XIII: Synthesis and cytotoxic activity of some 3,7-diaryl-5-(3,4,5-trimethoxyphenyl)pyrazolo[4,3-e][1,2,4]triazines. European Journal of Medicinal Chemistry. 2009, 44(2), 891-900. ISSN 0223-5234. IF: 2.882.
  • [2]
    BIEDERMANN, D., J. ŠAREK, J. KLINOT, M. HAJDÚCH a P. DŽUBÁK. Fluorination of betulinines and other triterpenoids with DAST. Synthesis-Stuttgart. 2005, -(7), 1157-1163. ISSN 0039-7881. IF: 2.203.
  • [1]
    BORKOVÁ, L., R. ADÁMEK, P. KALINA, P. DRAŠAR, P. DŽUBÁK, S. GURSKÁ, J. ŘEHULKA, M. HAJDÚCH, M. URBAN a J. ŠAREK. Synthesis and Cytotoxic Activity of Triterpenoid Thiazoles Derived from Allobetulin, Methyl Betulonate, Methyl Oleanonate, and Oleanonic Acid. ChemMedChem. 2017, 12(5), 390-398. ISSN 1860-7179. IF: 3.225.

Publications (Other Reviewed Journals):

Book Chapters:

  • [4]
    DŽUBÁK, P., M. URBAN a M. HAJDÚCH. Vývoj nových léčiv. In: Molekulární medicína. 1. vyd. Praha: Galén, 2015. Kapitola 11, s. 469-472. ISBN: 978-80-7492-121-6.
  • [3]
    CIBIČEK, N., J. VACEK, M. BERANEK, P. DŽUBÁK, Z. HEŘMANOVÁ, P. KOSINA, M. KUBALA, M. NOVÁK, B. PAPOUSKOVA, J. SROVNAL, J. VÁVROVÁ, J. VOSTALOVA, M. ZATLOUKALOVA a H. ŽIVNÁ. Hmotnostní spektrometrie. In: Principy a využití vybraných analytických metod v laboratorní medicíně. 1. vyd. Olomouc: Univerzita Palackého v Olomouci, 2014. Kapitola 2.2, s. 34-40. ISBN: 978-80-244-3951-8.
  • [2]
    CIBIČEK, N., J. VACEK, M. BERANEK, P. DŽUBÁK, Z. HEŘMANOVÁ, P. KOSINA, M. KUBALA, M. NOVÁK, B. PAPOUSKOVA, J. SROVNAL, J. VÁVROVÁ, J. VOSTALOVA, M. ZATLOUKALOVA a H. ŽIVNÁ. Elektrochemické metody, (bio)senzory a čipové platformy. In: Principy a využití vybraných analytických metod v laboratorní medicíně. 1. vyd. Olomouc: Univerzita Palackého v Olomouci, 2014. Kapitola 2.3, s. 43-44. ISBN: 978-80-244-3951-8.
  • [1]
    ŠAREK, J., M. KVASNICA, M. VLK, M. URBAN, P. DŽUBÁK a M. HAJDÚCH. The Potential of Triterpenoids in the Treatment of Melanoma. In: Research on Melanoma – A Glimpse into Current Directions and Future Trends. 1.vyd. Rijeka: InTech, 2011. Kapitola 7, s. 125-158. ISBN: 978-953-307-293-7.

Books:


Patents, Utility models & other IP's :

[13] SUBSTITUTED HETEROPENTADIENO-PYRROLOPYRIMIDINE RIBONUCLEOSIDES FOR THERAPEUTIC USE, PV 2016-465

Patent: CZ 307 334. Granted: 2. 5. 2018. Ownership: Palacky University, Olomouc. Inventors: Hocek Michal, Tokarenko Anna, Smoleń Sabina, Džubák Petr, Hajdúch Marián.

Status: Available.

[12] METHOD OF PREDICTING THE TUMOR RESPONSE TO DNA METHYLATION INHIBITORS AND ALTERNATIVE THERAPEUTIC REGIMENS FOR OVERCOMING RESISTANCE, EP 14161897.5
  1. Patent appl. EP 14161897.5 (ASH1L), Patent: EP 2924125, Granted: 17. 6. 2017, Ownership: Palacky University Olomouc, Inventors: Agrawal Khushboo, Frydrych Ivo, Džubák PetrHajdúch Marián
  2. Patent appl. EP 15717786.6 (BRD4), Patent: EP 3122902, Granted: 16. 5. 2018, Ownership: Palacký University, Olomouc, Inventors: Agrawal KhushbooFrydrych IvoDžubák PetrHajdúch Marián

​Status: Available 

[11] BENZOISOTHIAZOLE-1, 1-DIOXIDE-3-HYDRAZONES AND THEIR USE IN ANTICANCER THERAPY, PV 2014-322
  1. Patent: CZ 306 554, Granted: 25. 1. 2017, Ownership: Institute of Chemical technology Prague, Palacky University Olomouc, Institute of Molecular Genetics CAS, Inventors: Kaplánek Robert, Bříza Tomáš, Havlík Martin, Rak Jakub, Kejík Zdeněk, Džubák PetrHajdúch Marián, Konečný Petr, Štěpánková Jana, Králová Jarmila, Král Vladimír

​Status: Available 

[10] FLUORESCENT DERIVATIVE FOR NON-CATALYTIC LABELING OF NUCLEIC ACID AND PEPTIDE COMPONENTS, PUV 2016-32558
  1. Utility Model: CZ 30 136, Granted: 13. 12. 2016, Ownership: Palacky University, Olomouc, Inventors: Jedináková Petra, Hlaváč JanVáclavková Jana, Konečný Petr, Džubák Petr, Hajdúch Marián

Status: Available

[9] METHOD OF DETERMINATION OF CANCER CELL DRUG SENSITIVITY TOWARDS AURORA KINASE INHIBITORS AND OVERCOMIMG THEIR RESISTANCE, Priority Appl. EP 1192330.6
  1. Patent: EP 2788504, Granted: 21. 7. 2016, Ownership: Palacky University Olomouc, Institute of Animal Physiology and Genetics AS CR, Inventors: Kollaredy MadhuHajdúch MariánDžubák PetrSrovnal JosefHrabáková, Kovářová Hana  
  2. Patent: JP 6144696, Granted: 19. 5. 2017, Ownership: Palacky University Olomouc, Institute of Animal Physiology and Genetics AS CR, Inventors: Kollaredy Madhu, Hajdúch MariánDžubák PetrSrovnal Josef, Hrabáková, Kovářová Hana

Status: Available

[8] CARBONIC ANHYDRASE INHIBITORS AND METHOD OF THEIR PRODUCTION, Priority Appl. CZ PV 2011-676
  1. Patent: EP 2 771 015, Granted: 16. 3. 2016, Ownership: Institute of Organic Chemistry and Biochemistry AS CR, Institute of Molecular Genetics AS CR, Institute of Inorganic Chemistry AS CVR, Palacky University Olomouc, Inventors: Brynda Jiří, Cígler Petr, Gruner Bohumír, Maloy Řezáčová Pavlína, Mader Pavel, Šícha Václav, Bakardijev Mario, Džubák PetrHajdúch Marián
  2. Patent: US 9,290,529, Granted: 22. 3. 2016, Ownership: Institute of Organic Chemistry and Biochemistry AS CR, Institute of Molecular Genetics AS CR, Institute of Inorganic Chemistry AS CVR, Palacky University Olomouc, Inventors: Brynda Jiří, Cígler Petr, Gruner Bohumír, Maloy Řezáčová Pavlína, Mader Pavel, Šícha Václav, Bakardijev Mario, Džubák PetrHajdúch Marián

Status: Available

[7] CULTURE DISH, Priority Appl. CZ PUV 2015-31565, Priority Appl. CZ PVZ 2015-40394
  1. Utility Model: CZ 28 806, Granted: 10. 11. 2015, Ownership: Palacky University Olomouc, Inventors: Džubák PetrHajdúch Marián
  2. Design: CZ 36 622, Granted: 28. 12. 2015, Ownership: Palacky University Olomouc, Inventors: Džubák PetrHajdúch Marián
  3. Registered Community Design: RCD 003039577-0001, Granted: 23. 3. 2016, Ownership: Palacky University Olomouc, Inventors: Džubák PetrHajdúch Marián
  4. Registered Community Design: RCD 003039577-0002, Granted: 23. 3. 2016, Ownership: Palacky University Olomouc, Inventors: Džubák PetrHajdúch Marián

Status: Available 

[6] ASYMMETRIC TROGER BASES WITH HYDRAZONE GROUP AND THEIR USE IN THE TREATMENT OF ONCOLOGIC DISEASES, Priority Appl. CZ PV 2014-317
  1. Patent: CZ 305 683, Granted: 23. 12. 2015, Ownership: Institute of Chemical technology Prague, Palacky University Olomouc, Institute of molecular genetics AS CR, Inventors: Rak Jakub, Kaplánek Robert, Štulcová Tereza, Drašar Pavel, Havlík Martin, Bříza Tomáš, Džubák PetrHajdúch MariánKonečný PetrŠtěpánková Jana, Králová Jarmila, Král Vladimír

Status: Available  

[5] DIOXOCYCLOBUTENYL HYDRAZONES AND THEIR ANTICANCER ACTIVITY, Priority Appl. CZ PV 2014-321
  1. Patent: CZ 305 626, Granted: 2. 12. 2015, Ownership: Institute of Chemical technology Prague, Palacky University Olomouc, Institute of molecular genetics AS CR, Inventors: Havlík Martin, Kaplánek Robert, Dolenský Bohumil, Rak Jakub, Bříza Tomáš, Džubák PetrHajdúch MariánKonečný PetrŠtěpánková Jana, Králová Jarmila, Král Vladimír

Status: Available 

[4] CAFFEINE-8-HYDRAZONES AS NOVEL CYTOSTATICS FOR THE TREATMENT OF ONCOLOGIC DISEASES, Priority Appl. CZ PV 2014-307
  1. Patent: CZ 305 625, Granted: 2. 12. 2015, Ownership: Institute of Chemical technology Prague, Palacky University Olomouc, Institute of molecular genetics AS CR, Inventors: Rak Jakub, Kaplánek Robert, Štulcová Tereza, Drašar Pavel, Havlík Martin, Bříza Tomáš, Džubák PetrHajdúch MariánKonečný PetrŠtěpánková Jana, Králová Jarmila, Král Vladimír 

Status: Available 

[3] CHOLYL HYDRAZONES AND THEIR USE IN THE TREATMENT OF TUMOR AND LEUKEMIA DISEASES, Priority Appl. CZ PV 2014-305
  1. Patent: CZ 305 607, Granted: 25. 11. 2015, Ownership: Institute of Chemical technology Prague, Institute of molecular genetics AS CR, Palacky University OlomoucInventors: Rak Jakub, Kaplánek Robert, Štulcová Tereza, Drašar Pavel, Havlík Martin, Bříza Tomáš, Džubák PetrHajdúch MariánKonečný PetrŠtěpánková Jana, Králová Jarmila, Král Vladimír

Status: Available

[2] BENZOTHIAZOLE-SUBSTITUTED CYCLOBUT-3-ENE-1, 2-DIONE-3-HYDRAZONES AND THEIR USE IN THE TREATMENT OF VARIOUS TYPES OF LEUKEMIA AND TUMOUR DISEASES, Priority Appl. CZ PV 2014-306
  1. Patent: CZ 305 538, Granted: 14. 10. 2015, Ownership: Institute of Chemical Technology Prague, Palacky University Olomouc, Institute of Molecular Genetics AS CR, Inventors: Kaplánek Robert, Bříza Tomáš, Havlík Martin, Rak Jakub, Kejík Zdeněk, Krejčí Petr, Džubák PetrHajdúch MariánŠtěpánková JanaKonečný PetrKrálová Jarmila, Král Vladimír 

Status: Available

[1] SUBSTITUTED 7-DEZAPURIN RIBONUCLEOSIDES, Priority Appl. CZ PV 2013-845
  1. Patent: JP 5485172, Granted: 7. 5. 2014, Ownership: Institute of Organic Chemistry and Biochemistry AS CR, Palacky University Olomouc, Inventors: Hocek Michal, Nauš Petr, Caletková Olga, Džubák Petr, Hajdúch Marián
  2. Patent: CZ 305 466, Granted: 7. 9. 2015, Ownership: Institute of Organic Chemistry and Biochemistry AS CR, Palacky University Olomouc, Inventors: Hocek Michal, Nauš Petr, Caletková Olga, Džubák PetrHajdúch Marián 
  3. Patent: AU 20142777740, Granted: 25. 2. 2016, Ownership: Institute of Organic Chemistry and Biochemistry AS CR, Palacky University Olomouc, Inventors: Hocek Michal, Nauš Petr, Caletková Olga, Džubák PetrHajdúch Marián 
  4. Patent: US 9,586,986, Granted: 7. 3. 2017, Ownership: Institute of Organic Chemistry and Biochemistry AS CR, Palacky University Olomouc, Inventors: Hocek Michal, Nauš Petr, Caletková Olga, Džubák PetrHajdúch Mariá

Status: Available

 


Doctoral students mentor:

[13] Vaishali Uniyal, Kinase inhibitors in treatment of neurodegenerative disease,
Ph.D. specialization: Pediatrics, status: Ongoing, from: 2018
[12] Martina Matějková, Expression profiling effects of anticancer drugs,
Ph.D. specialization: Oncology, status: Ongoing, from: 2016
[11] Jarmila Stanková, Cytotoxic drugs molecular target identification by methods of cell biology and proteomics,
Ph.D. specialization: , status: Ongoing, from: 2016
[10] Martina Jakoubková, Expression profiling effect of anticancer drugs,
Ph.D. specialization: , status: Ongoing, from: 2015
[9] Lenka Řeháčková, Mechanism of multidrug resistance (MDR) in cancer cells,
Ph.D. specialization: , status: Ongoing, from: 2015
[8] Jana Kotulová, Adenosine receptor inhibitors, the development and optimization ,
Ph.D. specialization: , status: Ongoing, from: 2014
[7] Jana Václavková, Identification of mechanisms of action of molecules with anticancer effect,
Ph.D. specialization: , status: Ongoing, from: 2013
[6] Martin Holoubek, ,
Ph.D. specialization: , status: Ongoing, from: 2013 to 2018
[5] Jiří Řehulka, Mitochondria as a therapeutic target in cancer,
Ph.D. specialization: , status: Graduated, from: 2010 to 2017
[4] Petr Konečný, Screening of chemical compounds´ biological activities in vitro,
Ph.D. specialization: , status: Graduated, from: 2010 to 2016
[3] Gabriela Rylová, Identification of molecular targets of anticancer drugs by proteomic methods,
Ph.D. specialization: , status: Ongoing, from: 2009
[2] Tomáš Oždian, Cancer proteomics in clinical and experimental oncology,
Ph.D. specialization: , status: Graduated, from: 2009 to 2016
[1] Dušan Holub, Development of a method for the sensitive and quantitative determination of hepcidin in human serum using LCMS,
Ph.D. specialization: , status: Graduated, from: 2009 to 2016


Master students mentor:

[2] Eliška Růžičková, Evaluation of biological activity of demethylation drugs,
status: Graduated, from: 2013 to 2014
[1] Barbora Pastorková, Identification of molecular targets of anticancer drugs by immuno-affinity purification,
status: Graduated, from: 2013 to 2014


Bachelor students mentor:

[1] Kateřina Lónová, Development and basic characterization of the cell line resistant to the CDK inhibitors,
status: Graduated, from: 2015 to 2016