Pharmacology and toxicology

Introduction

Work in the program covers the range of studies associated with a biologically active substance- Its ingestion by the organism, its metabolism and transformation, its assimilation and its toxicity and adverse reactions. It involves the identification of the optimal mode of administration of the substance and the verification of its pharmacokinetics in a suitable animal model. It also involves the determination of the distribution of the substance in the various organs and tissues of the animal model.

Program leaders

Program highlights

Pharmacokinetic and pharmacodynamic studies of compounds that will simulate a clinical situation and can, potentially, be used for registration studies.
Cellular toxicity of tested substances.
Chemoprotective and biosafety studies of tested substances.
Studies on toxicity and use of photosensitizers in photodynamic therapy.