Škrott Zdeněk M.Sc.

Škrott Zdeněk M.Sc.'s picture
Academic Title: Mgr.
Phone: +420 585632144
Curriculum Vitae: download
Doctoral training
The role of the ubiquitin-proteasome system in tumorigenesis and cancer treatment
Regulated protein degradation is mediated by ubiquitin-proteasome system. Inhibition of proteasome proteolytic activity is a promising approach in cancer therapy with first-in-class drug bortezomib approved for the treatment of patients with multiple myeloma. Since ubiquitination regulates not only protein degradation but also wide variety of cellular signaling pathways, this new approach might bring new drugs with better efficacy and safety profiles.



Publications (Impact Factor Journals):

Master students mentor:

[1] Zuzana Machačová, The role of the p97 / NPL4 protein complex in repairing damaged DNA,
status: Ongoing, from: 2019

Bachelor students mentor:

[2] M. Kempná, Targeting NPL4 protein in cancer,
status: Ongoing, from: 2019
[1] Andrej Soos, Crosstalk between the ubiquitin proteasome system and genome integrity,
status: Ongoing, from: 2016