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Hajdúch Marián M.D., Ph.D.
Akademický titul:
Associate Professor
E-mail:
marian.hajduch@upol.cz
Telefon:
+420 585632082, +420 585632083
Skupiny:
ÚMTM, LEM, PERSONÁL, VEDOUCÍ
O mně
Scientist and medical professional mainly involved in molecular and translational medicine (disease area oncology. rare and infectious diseases); long-term experience in project management; R&D and technology transfer activities, including the construction and management of large research infrastructures. Founding director of the Institute of Molecular and Translational Medicine, Palacky University in Olomouc, CZ. He has been involved as principal investigator, investigator or clinical site manager in 19 clinical trials; actively participated in the research and/or management of >50 national and international projects; established Cancer Research Czech Republic as a major charity to support cancer research in CZ; spin-off companies focused on manufacturing of molecular diagnostics, bioinformatics and drug development; leader/co-leader drug development initiatives with one registered drug on market, several products in clinical trials, >35 in vitro diagnostic products on market, several CE IVD certified. Former Chair of the Boards of National Director and current Czech National Director for European Translational Medicine Infrastructure (EATRIS-ERIC); participated in creation of national network for personalized medicine and cancer management policies. Published more than >350 papers, 21 books/chapters, >40 patents, >6700 SCI citations, H-index 41.
Journals
Synthesis and evaluation of cyclobut-3-ene-1,2-dione-3-hydrazones with benzothiazole moiety as novel anticancer agents inducing nonapoptotic oncosis-like cell death.
Biomedicine & pharmacotherapy.
2025,
ISSN: 0753-3322,
PMID: 40763487,
Books & book chapters
The Potential of Triterpenoids in the Treatment of Melanoma,
1.vyd,
Rijeka,
InTech,
2011,
7,
125-158,
Dedication: 305/09/1216,
ISBN: 978-953-307-293-7,
Intellectual property
MOLECULAR COMPLEX ASSEMBLY PARTICLES COMRISING BIS-R1, R2-DITHIOCARBAMATE-METAL COMPLEX AND A LIGAND, METHOD OF PREPARATION AND USE THEREOF "DISULFIRAM II" (Mistrík)
- Published Application EP 18199181.1 under EP 3636285 (15.4.2020)
- Published Application PCT/EP2019/077222 under WO 2020/074514 (16.4.2020)
- Patent: AU 2019358428. Granted: 17.11.2022. Ownership: Palacký University Olomouc. Inventors: MISTRÍK Martin, BÁRTEK Jiří, ŠKROTT Zdeněk, DŽUBÁK Petr, HAJDÚCH Marián
- Patent: CA 3,114,031. Granted: 12.3.2024. Ownership: Palacký University Olomouc. Inventors: MISTRÍK Martin, BÁRTEK Jiří, ŠKROTT Zdeněk, DŽUBÁK Petr, HAJDÚCH Marián
- Patent: IL 281616. Granted: 2.4.2024. Ownership: Palacký University Olomouc. Inventors: MISTRÍK Martin, BÁRTEK Jiří, ŠKROTT Zdeněk, DŽUBÁK Petr, HAJDÚCH Marián
- Patent: JP 7220932. Granted: 3.2.2023. Ownership: Palacký University Olomouc. Inventors: MISTRÍK Martin, BÁRTEK Jiří, ŠKROTT Zdeněk, DŽUBÁK Petr, HAJDÚCH Marián
- Patent: KR 10-2626651. Granted: 17.1.2024. Ownership: Palacký University Olomouc. Inventors: MISTRÍK Martin, BÁRTEK Jiří, ŠKROTT Zdeněk, DŽUBÁK Petr, HAJDÚCH Marián
- Patent: MX 418,133. Granted: 29.10.2024. Ownership: Palacký University Olomouc. Inventors: MISTRÍK Martin, BÁRTEK Jiří, ŠKROTT Zdeněk, DŽUBÁK Petr, HAJDÚCH Marián
Status: Patents pending, Available
METHOD OF IDENTIFICATION OF ENTITIES FROM MASS SPECTRA (Hruška)
- Published Application EP 18184710.4 under EP 3598135 (22.1.2020)
- Published Application PCT/EP2019/069552 under WO 2020/016428 (23.1.2020)
- Patent: JP 7218019. Granted: 27.1.2023. Ownership: Palacký University Olomouc. Inventors: HRUŠKA Miroslav, HAJDÚCH Marián, DŽUBÁK Petr
- Patent: CA 3.106.053. Granted: 11.6.2024. Ownership: Palacký University Olomouc. Inventors: HRUŠKA Miroslav, HAJDÚCH Marián, DŽUBÁK Petr
Status: Available
PYRIDINOPYRROLOPYRIMIDINE RIBONUCLEOSIDES FOR THERAPEUTIC USE (Veselovská)
- Patent: CZ 308104. Granted: 27. 11. 2019. Ownership: Institute of Organic Chemistry and Biochemistry CAS, Palacký University Olomouc. Inventors: VESELOVSKÁ Lucia, HOCEK Michal, HAJDÚCH Marián, DŽUBÁK Petr
- Published Application PCT/CZ2019/050008 under WO 2019/174657 (19.9.2019)
- Patent: EP 3765475. Granted: 15.9.2021. Ownership: Institute of Organic Chemistry and Biochemistry CAS, Palacký University Olomouc. Inventors: VESELOVSKÁ Lucia, HOCEK Michal, HAJDÚCH Marián, DŽUBÁK Petr
- Patent: US 11,299,510. Granted: 12.4.2022. Ownership: Institute of Organic Chemistry and Biochemistry CAS, Palacký University Olomouc. Inventors: VESELOVSKÁ Lucia, HOCEK Michal, HAJDÚCH Marián, DŽUBÁK Petr
- Patent: CA 3.090.343. Granted: 4.10.2022. Ownership: Institute of Organic Chemistry and Biochemistry CAS, Palacký University Olomouc. Inventors: VESELOVSKÁ Lucia, HOCEK Michal, HAJDÚCH Marián, DŽUBÁK Petr
- Patent: JP 6973761. Granted: 8.11.202. Ownership: Institute of Organic Chemistry and Biochemistry CAS, Palacký University Olomouc. Inventors: VESELOVSKÁ Lucia, HOCEK Michal, HAJDÚCH Marián, DŽUBÁK Petr
- Patent: AU 2019235042. Granted: 17.6.2021. Ownership: Institute of Organic Chemistry and Biochemistry CAS, Palacký University Olomouc. Inventors: VESELOVSKÁ Lucia, HOCEK Michal, HAJDÚCH Marián, DŽUBÁK Petr
Status: Available
Doctoral mentorship
Vanek Peter M.Sc.
Factors affecting the participation of individuals in cancer screening programs.
Stav:
Probíhající od 2014 do 2014.
Agrawal Khushboo Ph.D.
5-Azacytidine Nucleosides and their Derivatives: Molecular Hallmarks of Drug Resistance & Alternative Therapeutic Regimen
Stav:
Absolvoval od 2010 do 2017.
Macečková Zuzana M.Sc.
Molecular pathology of Diamond-Blackfan anemia
Stav:
Absolvoval od 2014 do 2022.
Open positions
| Projekt: | Identification of molecular targets and mechanisms of drug resistance by cellular methods biology and proteomics |
|---|---|
| Vedoucí: | Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D. |
| K dispozici: | 2 |
| Určeno pro: | Doktorské studium |
| Souhrn: | 2 places in full-time study |
| Projekt: | Research and development of small-molecule drugs |
|---|---|
| Vedoucí: | Hajdúch Marián M.D., Ph.D. |
| K dispozici: | 2 |
| Určeno pro: | Doktorské studium |
| Souhrn: | 2 full-time positions |
| Projekt: | Identification of proteomic biomarkers in exhaled air condensate in patients with systemic or pulmonary disease |
|---|---|
| Vedoucí: | Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D. |
| K dispozici: | 2 |
| Určeno pro: | Doktorské studium |
| Souhrn: | 2 places in full-time study |
| Projekt: | Genetic and epigenetic biomarkers of cancer diseases |
|---|---|
| Vedoucí: | Slavkovský Rastislav Ph.D., Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D., Drábek Jiří Ph.D. |
| K dispozici: | 3 |
| Určeno pro: | Doktorské studium |
| Souhrn: | 3 places in full-time or combined form of study |
| Projekt: | Antitumor drugs targeting nucleic acid metabolism |
|---|---|
| Vedoucí: | Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D. |
| K dispozici: | 2 |
| Určeno pro: | Doktorské studium |
| Souhrn: | 2 places in full-time study |
| Projekt: | Drug repurposing for the treatment and prevention of diseases |
|---|---|
| Vedoucí: | Hajdúch Marián M.D., Ph.D., Dömling Alexander PhD. |
| K dispozici: | 1 |
| Určeno pro: | Doktorské studium |
| Souhrn: | 1 place in full-time study |
| Projekt: | Study of basic pharmacokinetic properties (ADME) of new drugs in preclinical development |
|---|---|
| Vedoucí: | Lišková Barbora Ph.D., Hajdúch Marián M.D., Ph.D. |
| K dispozici: | 1 |
| Určeno pro: | Doktorské studium |
| Souhrn: | 1 place in full-time study |
| Projekt: | Bioinformatics processing of big data within clinical and preclinical studies |
|---|---|
| Vedoucí: | Hajdúch Marián M.D., Ph.D., Pavliš Petr Ph.D. |
| K dispozici: | 3 |
| Určeno pro: | Doktorské studium |
| Souhrn: | 3 places in full-time or combined form of study |
| Projekt: | Development of drugs in the field of small molecules 2 places in full-time study |
|---|---|
| Vedoucí: | Dömling Alexander PhD., Hajdúch Marián M.D., Ph.D. |
| K dispozici: | 2 |
| Určeno pro: | Doktorské studium |
| Souhrn: | 2 places in full-time study |
| Projekt: | Diagnosis and treatment of rare diseases |
|---|---|
| Vedoucí: | Hajdúch Marián M.D., Ph.D., Srovnal Josef M.D., Ph.D. |
| K dispozici: | 2 |
| Určeno pro: | Doktorské studium |
| Souhrn: | 2 places in full-time study |
| Projekt: | Identification of new derivatives targeting precancerous and tumor lesions and their mechanisms of action |
|---|---|
| Vedoucí: | Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D. |
| K dispozici: | 2 |
| Určeno pro: | Doktorské studium |
| Souhrn: | 2 full-time positions |
| Projekt: | New diagnostic, prognostic, and predictive factors in solid tumors |
|---|---|
| Vedoucí: | Hajdúch Marián M.D., Ph.D. |
| K dispozici: | 2 |
| Určeno pro: | Doktorské studium |
| Souhrn: | 2 positions (full-time or part-time) |
| Projekt: | Identification of molecular targets and mechanisms of resistance in anticancer drugs using cell biology and proteomics |
|---|---|
| Vedoucí: | Hajdúch Marián M.D., Ph.D. |
| K dispozici: | 1 |
| Určeno pro: | Doktorské studium |
| Souhrn: | 1 full-time position |
| Projekt: | Anticancer drugs targeting nucleic acid metabolism |
|---|---|
| Vedoucí: | Hajdúch Marián M.D., Ph.D. |
| K dispozici: | 1 |
| Určeno pro: | Doktorské studium |
| Souhrn: | 1 full-time position |
| Projekt: | Bioinformatics processing of large datasets in clinical and preclinical studies |
|---|---|
| Vedoucí: | Hajdúch Marián M.D., Ph.D., Pavliš Petr Ph.D. |
| K dispozici: | 2 |
| Určeno pro: | Doktorské studium |
| Souhrn: | 2 positions (full-time or part-time) |
| Projekt: | Anticancer drugs targeting nucleic acid metabolism |
|---|---|
| Vedoucí: | Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D. |
| K dispozici: | 2 |
| Určeno pro: | Doktorské studium |
| Projekt: | Diagnosis and treatment of rare diseases |
|---|---|
| Vedoucí: | Hajdúch Marián M.D., Ph.D., Srovnal Josef M.D., Ph.D., Adam Tomáš Ph.D. |
| K dispozici: | 3 |
| Určeno pro: | Doktorské studium |
| Souhrn: | 3 full-time positions |
| Projekt: | Genetic and epigenetic biomarkers in health and disease |
|---|---|
| Vedoucí: | Slavkovský Rastislav Ph.D., Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D., Drábek Jiří Ph.D., Koudeláková Vladimíra Ph.D. |
| K dispozici: | 5 |
| Určeno pro: | Doktorské studium |
| Projekt: | Identification of proteomic biomarkers in exhaled breath condensate patients with systemic or pulmonary disease |
|---|---|
| Vedoucí: | Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D. |
| K dispozici: | 2 |
| Určeno pro: | Doktorské studium |
| Projekt: | Biologically active molecules and their therapeutic combinations |
|---|---|
| Vedoucí: | Hajdúch Marián M.D., Ph.D. |
| K dispozici: | 2 |
| Určeno pro: | Doktorské studium |
| Projekt: | Identification of proteomic biomarkers in proximal fluids and tissues |
|---|---|
| Vedoucí: | Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D. |
| K dispozici: | 2 |
| Určeno pro: | Doktorské studium |
| Projekt: | Research and development of agents for cancer, neurodegenerative and infectious diseases |
|---|---|
| Vedoucí: | De Sanctis Juan Bautista Ph.D., Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D., Urban Milan Ph.D., Das Viswanath M.Sc., Ph.D. |
| K dispozici: | 5 |
| Určeno pro: | Doktorské studium |
| Projekt: | Identification of molecular targets and mechanisms of resistance in antitumor drugs |
|---|---|
| Vedoucí: | Srovnal Josef M.D., Ph.D., Hajdúch Marián M.D., Ph.D. |
| K dispozici: | 2 |
| Určeno pro: | Doktorské studium |
| Souhrn: | 2 places in full-time study |
| Projekt: | Physiology and pathophysiology of aging |
|---|---|
| Vedoucí: | Hajdúch Marián M.D., Ph.D., Voller Jiří Ph.D. |
| K dispozici: | 2 |
| Určeno pro: | Doktorské studium |
| Souhrn: | 2 places in full-time study |