Cellular stress pathways are essential for cancer cells' survival and significantly contribute to therapeutic resistance. They help the cells to deal with various cancer hallmarks, including elevated DNA damage accompanied by accumulation of mutations, DNA replication problems, accumulation of defective proteins, free radicals, nutrient deficiency, hypoxia, etc. Our methods and expertise identify and target these stress pathways directly inside cancer cells. Such research has great potential in finding new prediction markers, improving standard anticancer therapy, and suggesting new therapeutic targets.
Cellular stress
Laboratory of Genome Integrity
Research interests
- DNA damage and repair and genomic instability
- Replication stress
- Mechanical stress
- Oncogenic and free radicals stress
Current projects
- Exploration of mechanical stress-promoted perturbation of the cell cycle in cancer cells.
- Identification and structural characterization of novel NPL4 inhibitors and insight into its mode of action.
- Cannabidiol as a potential attenuator of the efficacy of chemotherapeutics.
- Development of nano-formulated diethyldithiocarbamate-copper complex as an anticancer drug.
- Identification of new compounds with senolytic effect and mechanism of their action in senescent cells.
- Insight into cellular proteotoxic stress response using new microthermal protein damage methodology.
- Effects of long-term mild hypothermia (fever-like hyperthermia) on cancer cells.
- Cellular DNA damage response in the context of cance.
Selected publications
Superresolution live imaging of plant cells using structured illumination microscopy. Nature Protocols. 2015, 10(8), 1248-1263, ISSN: 1754-2189, PMID: 26203822,
Open positions
1 Molecular and Translational Medicine
| Project: | Cellular stress in health and disease |
|---|---|
| Supervisors: | Mistrík Martin Ph.D., Moudrý Pavel Ph.D., Škrott Zdeněk Ph.D. |
| Available: | 3 |
| Intended for: | Doctoral training |