Contakt

Nová Alice Ph.D.

Academic Title: PharmDr.
Phone: +420 585632334, +420 585632244
Groups: Exstaff, LEM
Curriculum Vitae: alice_nova_cv-en.pdf

About me

Researcher experienced in the field of early ADME (absorption, distribution, metabolism and excretion) profiling of drug candidates.Research interests: determination of in vitro ADME properties of NCEs (new chemical entities), i.e. assessment of NCEs GIT permeability, identification of P-glycoprotein substrates, prediction of blood brain barrier permeability, determination of chemical and metabolic stability, determination of the NCEs stability in plasma, determination of NCEs plasma protein binding.Published 5 scientific papers, 20 SCI citations, H-index 2. Publications:Techlovská S, Chambers JN, Dvořáková M, Petralia RS, Wang YX, Hájková A, Nová A, Franková D, Prezeau L, Blahoš J. Metabotropic glutamate receptor 1 splice variants mGluR1a and mGluR1b combine in mGluR1a/b dimers in vivo. Neuropharmacology. 2014, 86, 329-36. ISSN: 0028-3908. IF (2013): 4.819. PMID: 25158311Rulcova A, Krausova L, Smutny T, Vrzal R, Dvorak Z, Jover R, Pavek P. Glucocorticoid receptor regulates organic cation transporter 1 (OCT1, SLC22A1) expression via HNF4α upregulation in primary human hepatocytes. Pharmacol Rep. 2013, 65(5), 1322-35. ISSN: 1734-1140. IF (2012): 1,965. PMID: 24399729Rulcova A, Prokopova I, Krausova L, Bitman M, Vrzal R, Dvorak Z, Blahos J, Pavek P. Stereoselective interactions of warfarin enantiomers with Pregnane X nuclear (PXR) receptor in gene regulation of major drug-metabolizing cytochrom P450 enzymes. J Thromb Haemost. 2010, 8(12), 2708-17. ISSN: 1538-7933. IF (2009): 6,069. PMID: 20735727                           
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