Mašek Vlastimil Ph.D.

Phone: +420-585 63 2181 Office, +420-585 63 2147 Lab
Curriculum Vitae: download here

Research interests:

Biomedical applications of Raman and infrared specroscopy
- drug distribution in cells using Raman imaging
- microorganism identification using Raman/infrared specroscopy
- DNA/protein-ligand interaction monitored by Raman spectroscopy
- infrared spectroscopy in the diagnosis of prostate and other cancers

Fig. bright-field image of fixed cells (left) and corresponding Raman map showing drug distribution (right).


Ph.D. students:

  • Monika Harvanová M.Sc.

"Imaging methods for study of potential drugs distribution on the cellular level"

  • Martina Michalová M.Sc.

"Study of interactions of small biologically active molecules with selected target macromolecules"

Publications (Impact Factor Journals)

  • [9]
    GRUNER, B., J. BRYNDA, V. DAS, V. SICHA, J. ŠTĚPÁNKOVÁ, J. NEKVINDA, J. HOLUB, K.. POSPISILOVA, M. FABRY, P. PACHL, V. KRAL, M. KUGLER, V. MAŠEK, M. MEDVEDÍKOVÁ, S. MATEJKOVA, A. NOVÁ, B. LIŠKOVÁ, S. GURSKÁ, P. DŽUBÁK, M. HAJDÚCH a P. ŘEZÁČOVÁ. Metallacarborane Sulfamides: Unconventional, Specific, and Highly Selective Inhibitors of Carbonic Anhydrase IX. Journal of Medicinal Chemistry. 2019, 62(21), 9560-9575. ISSN 0022-2623. IF: 6.054. PMID: 31568723
  • [8]
    PELC, R., V. MAŠEK, V. LLOPIS-TORREGROSA, P. BOUR a T. WU. Spectral counterstaining in luminescence-enhanced biological Raman microscopy. Chemical Communications (Cambridge, England). 2019, 55(57), 8329-8332. ISSN 1359-7345. IF: 6.164. PMID: 31257378
  • [7]
    WU, T., J. KAPITAN, V. MAŠEK a P. BOUR. Detection of Circularly Polarized Luminescence of a Cs-EuIII Complex in Raman Optical Activity Experiments. Angewandte Chemie (International ed. in English). 2015, 54(49), 14933-6. ISSN 1433-7851 . IF: 11.709. PMID: 26473499
  • [6]
    VITEK, P., J. JEHLICKA, C. ASCASO, V. MAŠEK, B. GOMEZ-SILVA, H. OLIVARES a J. WIERZCHOS. Distribution of scytonemin in endolithic microbial communities from halite crusts in the hyperarid zone of the Atacama Desert, Chile. Fems Microbiology Ecology. 2014, 90(2), 351-366. ISSN 0168-6496. IF: 3.568. PMID: 25056905
  • [5]
    MAŠEK, V., P. STARHA, M. HARVANOVÁ, M. MICHALOVÁ, D. MILDE, Z. TRAVNICEK a E. ANZENBACHEROVÁ. Interaction of selected platinum(II) complexes containing roscovitine-based CDK inhibitors as ligands with human liver microsomal cytochrome P450. Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czech Republic. 2015, 159(3), 382-387. ISSN 1213-8118. IF: 0.924. PMID: 25004912
  • [4]
    BERKA, K., E. ANZENBACHEROVÁ, T. HENDRYCHOVA, R. LANGE, V. MAŠEK, P. ANZENBACHER a M. OTYEPKA. Binding of quinidine radically increases the stability and decreases the flexibility of the cytochrome P450 2D6 active site. Journal of Inorganic Biochemistry. 2012, 110(-), 45-60. ISSN 0162-0134. IF: 3.197. PMID: 22459173
  • [3]
    MAŠEK, V., E. ANZENBACHEROVÁ, T. ETRYCH, J. STROHALM, K. ULBRICH a P. ANZENBACHER. Interaction of N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugates with human liver microsomal cytochromes P450: Comparison with free doxorubicin. Drug Metabolism and Disposition. 2011, 39(9), 1704-1710. ISSN 0090-9556. IF: 3.733. PMID: 21642392
  • [2]
    KROPAC, K., Z. DOLNICEK, D. BURIÁNEK, T. URUBEK a V. MAŠEK. Carbonate inclusions in Lower Cretaceous picrites from the Hončova hůrka Hill (Czech Republic, Outer Western Carpathians): Evidence for primary magmatic carbonates?. International Journal of Earth Science. 2015, 104(-), 1299-1315. ISSN 1437-3254 . IF: 2.133.
  • [1]
    HAVLIK, J., H. RAABOVA, M. GULKA, V. PETRAKOVA, M. KRECMANOVA, V. MAŠEK, P. LOUSA, J. STURSA, H. BOYEN, M. NESLADEK a P. CIGLER. Benchtop Fluorination of Fluorescent Nanodiamonds on a Preparative Scale: Toward Unusually Hydrophilic Bright Particles. Advanced Functional Materials. 2016, 26(23), 4134-4142. ISSN 1616-301X. IF: 12.124.
  • Publications (Other Reviewed Journals)

  • [2]
    DOLNICEK, Z., B. FOJT a V. MAŠEK. Podmínky vzniku mineralizace rudních sloupů ložiska Zlaté Hory-jih: pohled ze studia fluidních inkluzí. Bull Mineral Petrolog. 2018, 26(1), 64-73. ISSN 2570-7337.
  • [1]
    HARVANOVÁ, M., V. MAŠEK, D. JIROVA a H. KOLÁŘOVÁ. Raman label-free visualisation of titanium dioxide nanoparticles uptake in BJ cell lines. Lékař a technika. 2016, 46(1), 28-25. ISSN 0301-5491.

  • Doctoral students mentor:

    [1] Martina Medvedíková, Study of interaction of biologically active small molecules with selected target macromolecules,
    Ph.D. specialization: , status: Ongoing, from: 2013