The research is focused on human virology, public health surveillance, the molecular mechanisms of virus-driven infections, diseases and specifically carcinogenesis. The group is focused mainly on HPV-associated diseases, SARS-CoV-2 immunity, and cancer genetics. The Laboratory of virology and molecular carcinogenesis was recently established as a junior research group. The researchers from the Laboratory of virology and molecular carcinogenesis are involved in molecular investigation of human papillomaviruses (HPV) and recently in SARS-CoV-2 infections. The workplace is fully equipped with state-of-the-art instruments for genetic and molecular biology analyses of human biological materials.
Virology and molecular carcinogenesis
Laboratory of Experimental Medicine
Research interests
- Human virology
- Public health surveillance
- Molecular carcinogenesis of HPV-driven cancers
- SARS-CoV-2 immunity
- National screening and vaccination programmes improvement
- New approaches in screening testing
- Diagnostic and therapeutic targets
Current projects
- KOPRETINA trial – The main goal of the study is to determine the prevalence and genotype distribution of Human Papillomavirus in vaccinated/unvaccinated Czech women. The second goal is to evaluate the usage of self-sampling device mainly in women who do not participate in cytology-based cervical cancer screening and in women who participate in cervical cancer screening.
- Liquid biopsies - a possible tool for treatment monitoring and early recurrence detection in HPV-associated diseases – The main goal of the study is monitoring of HPV DNA dynamics in patients with HPV-positive oropharyngeal and cervical cancer/precancer. The second goal is to evaluate the importance of circulating HPV DNA in liquid biopsies for the treatment efficacy and relapse monitoring.
- PREVAL - Study of Collective Immunity – The main goal of the study is to evaluate the amount of SARS-CoV-2 antibodies, the presence of infection and the cell immunity response in people from Olomouc region.