Kocourková Lenka M.Sc.

Phone: +420 588444242

Groups: DOCTORAL STUDENT

Effect of coregulators on the androgen receptor activity in cells derived from prostate cancer after their treatment with histone deacetylase inhibitor

The thesis is focused on the detection of coregulator expressions in cancer and normal prostate cells. Coregulators, coactivators as well as coregulators, play an important role in androgen receptor-mediated progression of the prostate cancer. There is a competition between coactivators and corepressors for binding on the androgen receptor and therefore, the changes and the expression ratio between could be important for prostate cancer growth and progression. We focus on two regulators: SMRT (silencing mediator for retinoid and thyroid hormone receptors) as corepressor, and p300 as coactivator.

Specialization: Medical biology

Supervisor: Smešný Trtková Kateřina Ph.D.

Status: Graduated from 2009 to 2014.

SIKOROVÁ, K., A. KISHORE, A. RAPTI, A. KALLIOPI, L. KOCOURKOVÁ, V. ŽIŽKOVÁ, M. CHARIKIOPOULOU, A. KALIANOS, E. BOUROS, D. BOUROS, M. PETŘEK

Association of TGF-β3 and ANXA11 With Pulmonary Sarcoidosis in Greek Population. Expert Review of Respiratory Medicine. 2020, 14(10), 1065-1069, ISSN: 1747-6348, PMID: 32552203,

PETŘEK, M., L. KOCOURKOVÁ, V. ŽIŽKOVÁ, Z. NOSEK, M. TABORSKY, J. PETŘKOVÁ

Characterization of three CYP2C19 gene variants by Mass Array and Point of care techniques - experience from a Czech centre. Archivum Immunologiae et Therapiae Experimentalis. 2016, 64, 99-107, ISSN: 0004-069X, PMID: 28083610,

KISHORE, A., V. ŽIŽKOVÁ, L. KOCOURKOVÁ, J. PETŘKOVÁ, E. BOUROS, H. NUNES, V. LOSTAKOVA, J. MÜLLER-QUERNHEIM, G. ZISSEL, V. KOLEK, D. BOUROS, D. VALEYRE, M. PETŘEK

Association Study for 26 Candidate Loci in Idiopathic Pulmonary Fibrosis Patients from Four European Populations. Frontiers in Immunology. 2016, 7(-), 274, ISSN: 1664-3224, PMID: 27462317, PDF.

Kocourková Lenka M.Sc.

Doctoral training

Journals