Aim of our research group is to advance our understanding of aging and age-related disorders with major emphasis on Alzheimer’s disease. To achieve this goal we combine basic and translational neuroscience approaches.
Among the basic neuroscience questions, we focus on deciphering the role of impairments in axonal transport and of the axonal defects in aging and neurodegeneration. Moreover, we are also interested in elucidating the role of astrocytes in these processes with particular attention to the Amyloid precursor protein biology and pathology.
Among the translational neuroscience questions, we investigate cognitive, transcriptomic and proteomic changes of aging at the intersection with early clinical cognitive phenotypes. In addition, we explore the processes involved in cognitive testing and their potential impact on measurement results, as well as develop new methods for testing individual domains of cognition.
