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Biologically active derivatives of N6-benzyladenosine-5´-monophosphate


Cytokinin ribosides are phytohormones with anticancer activities against a range of cancer cell lines including leukemia stem cells. Their activity was confirmed in several xenograft models.


The present invention relates to the use of a compound of formula (I) for treatment of patients suffering from cancers or other proliferative disorders. Cytokinin ribosides, N6-substituted derivatives of adenosin, have only a limited water solubility which complicates preparation of pharmaceutically acceptable formulations. Introduction of 5´-phosphate moiety increases polarity and allows much higher solubility. Parent compound is released by the activity of serum/tissue esterases.

Advantages over existing solutions

The invention provides a novel class of cytokinin prodrugs with improved solubility profile.

Technology IP owners

BioApex, s.r.o
Olomouc Institute of Molecular and Translational Medicine, Faculty of Science, Palacky University, Olomouc

Commercial offer

Exclusive/non-exclusive license to the know-how and data


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