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Academic title: MSc.
Phone: +420 731 045 840
Groups: DOCTORAL STUDENT, IMTM, LEM, STAFF

Doctoral training

Study of neurodegeneration and aging on model organisms

Finding the appropriate functioning medication against parasites and bacteria is a constant struggle against evolution. Having sufficient alternative options that are both safe and effective is key to successfully battling these maladies. Thus it falls to us to screen as many chemical compounds for their potential toxicity in cells, multicellular organisms, such as nematodes or tardigrades, and discern their possible medical or veterinary applications. By using our cutting edge technologies present at IMTM, along with high through-put analysis using convolutional neural networks, we are able to screen compounds for their properties.

Specialization: Pediatrics
Status: Ongoing from 2019.

About me

Researcher and Ph.D. student at the Institute of Molecular and Translational Medicine specialized in experimental biology and chemical screening. During my studies I have conducted research in many fields including neurodegeneration in Friedrich ataxia cell lines, screening for nematicide activity of compounds in C. elegans and related parasites and Tardigrade cultivation and transcriptomics studies. My studies will hopefully lead to discovery of safe novel drugs with nematicide properties and to furthering the understanding behind tardigrade resilience.

ORCID: https://orcid.org/0000-0002-8992-8547

Journals

KADLECOVA, A., K. DZEDULIONYTE MÜLDÜR, M. PERINA, K. BIELESZOVA, C. ZHANG, D. KOVÁŘÍČEK, E. VALDERAS-GARCIA, D. VÍTEK, M. VALIKONYTE, A. SACKUS, J. SOLOVJOVA, V. MALINAUSKIENE, K. DOLEZAL, O. NOVAK, F. GRUNDLER, P. ROY, M. MARTINEZ-VALLADARES, J. VOLLER, A. SCHLEKER
Synthesis, Anthelmintic Activity, and Mechanism of Action of 5-Aryl-1 H-indoles. Journal of Agricultural and Food Chemistry. 2025, ISSN: 0021-8561 , PMID: 41401077,
SUSHOVAN, J., G. GONZALES, D. VÍTEK, M. KVASNICOVA, S. STEPANKOVA, M. STRNAD, J. VOLLER, K. CHANDA
Novel neuroprotective 5,6-dihydropyrido[2',1':2,3]imidazo[4,5-c]quinoline derivatives acting through cholinesterase inhibition and CB2 signaling modulation. European Journal of Medicinal Chemistry. 2024, 276, 116592, ISSN: 0223-5234, PMID: 39013357,  PDF.
MAKOVA, B., V. MIK, B. LIŠKOVÁ, G. GONZALES, D. VÍTEK, M. MEDVEDÍKOVÁ, B. MONFORT, V. RUČILOVÁ, A. KADLECOVA, P. KHIRSARIYA, Z. BARREIRO, L. HAVLICEK, M. ZATLOUKAL, M. SOURAL, K. PARUCH, B. D´AUTREAUX, M. HAJDÚCH, M. STRNAD, J. VOLLER
Cytoprotective activities of kinetin purine isosteres. Bioorganic & Medicinal Chemistry. 2021, 1(33), 115993, ISSN: 0968-0896, PMID: 33497938,