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Hajdúch Marián M.D., Ph.D.

Journals

Novel triterpenoid pyrones, phthalimides and phthalates are selectively cytotoxic in CCRF-CEM cancer cells - Synthesis, potency, and mitochondrial mechanism of action. European Journal of Medicinal Chemistry. 2024, 269, 116336, ISSN: 0223-5234, PMID: 38520761,  PDF.
VERCAMMEN, H., M. ONDRA, J. KOTULOVÁ, E. DE LA HOZ, C. WITTERS, K. JEČMEŇOVÁ, M. LE COMPTE, C. DEBEN, S. DHUBHGHAILL, C. KOPPEN, M. HAJDÚCH, B. VAN DEN BOGERD
"Keep on ROCKIn": Repurposed ROCK inhibitors to boost corneal endothelial regeneration. Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie. 2024, 174, 116435, ISSN: 0753-3322, PMID: 38513591,  PDF.
STANKOVÁ, J., M. JURÁŠEK, M. HAJDÚCH, P. DŽUBÁK
Terpenes and Terpenoids Conjugated with BODIPYs: An Overview of Biological and Chemical Properties. Journal of Natural products. 2024, 87(4), 1306-1319, ISSN: 0163-3864, PMID: 38482846,  PDF.

Intellectual property

DIOXOCYCLOBUTENYL HYDRAZONES AND THEIR ANTICANCER ACTIVITY (Kaplánek)
  1. Patent: CZ 305626. Granted: 2.12.2015. Ownership: Institute of Chemical Technology Prague; Palacký University Olomouc; Institute of Molecular Genetics CAS. Inventors: KAPLÁNEK Robert, BŘÍZA Tomáš, HAVLÍK Martin, RAK Jakub, KEJÍK Zdeněk, DŽUBÁK PetrHAJDÚCH Marián, KONEČNÝ Petr, ŠTĚPÁNKOVÁ Jana, KRÁLOVÁ Jarmila, KRÁL Vladimír

​Status: Terminated

BENZOISOTHIAZOLE-1, 1-DIOXIDE-3-HYDRAZONES AND THEIR USE IN ANTICANCER THERAPY (Kaplánek)
  1. Patent: CZ 306554. Granted: 25.1 2017. Ownership: Institute of Chemical Technology Prague; Palacký University Olomouc; Institute of Molecular Genetics CAS. Inventors: KAPLÁNEK Robert, BŘÍZA Tomáš, HAVLÍK Martin, RAK Jakub, KEJÍK Zdeněk, DŽUBÁK PetrHAJDÚCH Marián, KONEČNÝ Petr, ŠTĚPÁNKOVÁ Jana, KRÁLOVÁ Jarmila, KRÁL Vladimír

​Status: Terminated

BENZOTHIAZOLE-SUBSTITUTED CYCLOBUT-3-ENE-1, 2-DIONE-3-HYDRAZONES AND THEIR USE IN THE TREATMENT OF VARIOUS TYPES OF LEUKEMIA AND TUMOUR DISEASES (Kaplánek)
  1. Patent: CZ 305538. Granted: 14.10.2015. Ownership: Institute of Chemical Technology Prague; Palacký University Olomouc; Institute of Molecular Genetics CAS. Inventors: KAPLÁNEK Robert, BŘÍZA Tomáš, HAVLÍK Martin, RAK Jakub, KEJÍK Zdeněk,  DŽUBÁK PetrHAJDÚCH Marián, KONEČNÝ Petr, ŠTĚPÁNKOVÁ Jana, KRÁLOVÁ Jarmila, KRÁL Vladimír 

Status: Terminated

Open positions

Project: Identification of molecular targets and mechanisms of drug resistance by cellular methods biology and proteomics
Supervisors: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Summary: 2 places in full-time study
Project: Research and development of small-molecule drugs
Supervisors: Hajdúch Marián M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Summary: 2 full-time positions
Project: Identification of proteomic biomarkers in exhaled air condensate in patients with systemic or pulmonary disease
Supervisors: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Summary: 2 places in full-time study
Project: Genetic and epigenetic biomarkers of cancer diseases
Supervisors: Slavkovský Rastislav Ph.D., Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D., Drábek Jiří Ph.D.
Available: 3
Intended for: Doctoral training
Summary: 3 places in full-time or combined form of study
Project: Antitumor drugs targeting nucleic acid metabolism
Supervisors: Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Summary: 2 places in full-time study
Project: Drug repurposing for the treatment and prevention of diseases
Supervisors: Hajdúch Marián M.D., Ph.D., Dömling Alexander PhD.
Available: 1
Intended for: Doctoral training
Summary: 1 place in full-time study
Project: Study of basic pharmacokinetic properties (ADME) of new drugs in preclinical development
Supervisors: Lišková Barbora Ph.D., Hajdúch Marián M.D., Ph.D.
Available: 1
Intended for: Doctoral training
Summary: 1 place in full-time study
Project: Bioinformatics processing of big data within clinical and preclinical studies
Supervisors: Hajdúch Marián M.D., Ph.D., Pavliš Petr Ph.D.
Available: 3
Intended for: Doctoral training
Summary: 3 places in full-time or combined form of study
Project: Development of drugs in the field of small molecules 2 places in full-time study
Supervisors: Dömling Alexander PhD., Hajdúch Marián M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Summary: 2 places in full-time study
Project: Diagnosis and treatment of rare diseases
Supervisors: Hajdúch Marián M.D., Ph.D., Srovnal Josef M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Summary: 2 places in full-time study
Project: Identification of new derivatives targeting precancerous and tumor lesions and their mechanisms of action
Supervisors: Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Summary: 2 full-time positions
Project: New diagnostic, prognostic, and predictive factors in solid tumors
Supervisors: Hajdúch Marián M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Summary: 2 positions (full-time or part-time)
Project: Identification of molecular targets and mechanisms of resistance in anticancer drugs using cell biology and proteomics
Supervisors: Hajdúch Marián M.D., Ph.D.
Available: 1
Intended for: Doctoral training
Summary: 1 full-time position
Project: Anticancer drugs targeting nucleic acid metabolism
Supervisors: Hajdúch Marián M.D., Ph.D.
Available: 1
Intended for: Doctoral training
Summary: 1 full-time position
Project: Bioinformatics processing of large datasets in clinical and preclinical studies
Supervisors: Hajdúch Marián M.D., Ph.D., Pavliš Petr Ph.D.
Available: 2
Intended for: Doctoral training
Summary: 2 positions (full-time or part-time)
Project: Anticancer drugs targeting nucleic acid metabolism
Supervisors: Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Project: Diagnosis and treatment of rare diseases
Supervisors: Hajdúch Marián M.D., Ph.D., Srovnal Josef M.D., Ph.D., Adam Tomáš Ph.D.
Available: 3
Intended for: Doctoral training
Summary: 3 full-time positions
Project: Genetic and epigenetic biomarkers in health and disease
Supervisors: Slavkovský Rastislav Ph.D., Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D., Drábek Jiří Ph.D., Koudeláková Vladimíra Ph.D.
Available: 5
Intended for: Doctoral training
Project: Identification of proteomic biomarkers in exhaled breath condensate patients with systemic or pulmonary disease
Supervisors: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Project: Biologically active molecules and their therapeutic combinations
Supervisors: Hajdúch Marián M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Project: Identification of proteomic biomarkers in proximal fluids and tissues
Supervisors: Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Project: Research and development of agents for cancer, neurodegenerative and infectious diseases
Supervisors: De Sanctis Juan Bautista Ph.D., Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D., Urban Milan Ph.D., Das Viswanath M.Sc., Ph.D.
Available: 5
Intended for: Doctoral training
Project: Identification of molecular targets and mechanisms of resistance in antitumor drugs
Supervisors: Srovnal Josef M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Summary: 2 places in full-time study
Project: Physiology and pathophysiology of aging
Supervisors: Hajdúch Marián M.D., Ph.D., Voller Jiří Ph.D.
Available: 2
Intended for: Doctoral training
Summary: 2 places in full-time study