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De Sanctis Juan Bautista Ph.D.
Academic title:
Professor
E-mail:
juanbautista.desanctis@upol.cz
Phone:
776391255
Groups:
IMTM, LEM, STAFF
About me
I was initially formed in Biochemistry (Temple University), and then I did doctoral studies in physiological sciences, specialising in Biochemistry, Metabolism and immunology. I was a professor for more than 30 years at the Faculty of Medicine and the Institute of Immunology of the Faculty of Medicine of Universidad Central de Venezuela. My big area of expertise is inflammation, with ample background in immune response, cell metabolism, lipidomic, signal transduction and pharmacology. Currently, I am involved in a project on Cancer and immune response and others in Covid and long Covid (pending funding).
Journals
Treatment of Allergic Asthma With Fenretinide Formulation (LAU-7b) Downregulates ORMDL Sphingolipid Biosynthesis Regulator 3 ( Ormdl3) Expression and Normalizes Ceramide Imbalance.
The Journal of Pharmacology and Experimental Therapeutics.
2020,
373(3),
476-487,
ISSN: 0022-3565,
PMID: 32273303,
Efficacy of Optimized Treatment Protocol Using LAU-7b Formulation against Ovalbumin (OVA) and House Dust Mite (HDM) -Induced Allergic Asthma in Atopic Hyperresponsive A/J Mice.
Pharmacological Research.
2020,
37(2),
31,
ISSN: 0724-8741,
PMID: 31915990,
Fenretinide favorably affects mucins (MUC5AC/MUC5B) and fatty acid imbalance in a manner mimicking CFTR-induced correction.
Biochimica et biophysica acta. Molecular and cell biology of lipids.
2019,
1865(2),
158538,
ISSN: 1388-1981,
PMID: 31678518,
Open positions
| Project: | Role of PD1 signaling in the immune response against solid tumors |
|---|---|
| Supervisors: | De Sanctis Juan Bautista Ph.D. |
| Available: | 2 |
| Intended for: | Doctoral training |
| Summary: | 1 position (full-time), 1 position (part-time) |
| Project: | Research and development of agents for cancer, neurodegenerative and infectious diseases |
|---|---|
| Supervisors: | De Sanctis Juan Bautista Ph.D., Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D., Urban Milan Ph.D., Das Viswanath M.Sc., Ph.D. |
| Available: | 5 |
| Intended for: | Doctoral training |