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Phone: +420 585634873
Groups: IMTM, LIG, STAFF

About me

Specializing in cellular stresses and their link to cancer development and treatment. Another specialization includes advanced microscopic techniques (the head of the bioimaging core facility: https://imtm.cz/core-facilities/bioimaging-core-facility ). Actively participated in the research of more than 10 national and international projects. Published more than >40 original investigations and three patents, >3000 citations, H-index 24

Journals

CHYRA, Z., T. SEVCIKOVA, P. VOJTA, J. PUTEROVA, L. BROZOVA, K. GROWKOVA, J. FILIPOVA, M. ZATOPKOVA, S. GROSICKI, A. BARCHNICKA, W. JEDRZEJCAK, A. WASCUK-GAJDA, A. JUNGOVA, A. MIKULASOVA, M. HAJDÚCH, M. MOKREJS, L. POUR, M. STORK, L. HARVANOVA, M. MISTRÍK, G. MIKALA, P. ROBAK, A. CZYZ, J. DEBSKI, L. USNARSKA-ZUBKIEWICZ, A. JURCZYSZYN, L. STEJSKAL, G. MORGAN, F. KRYUKOV, E. BUDINSKA, M. SIMICEK, T. JELINEK, M. HRDINKA, R. HAJEK
Heterogenous mutation spectrum and deregulated cellular pathways in aberrant plasma cells underline molecular pathology of light-chain amyloidosis. Haematologica. 2020, 106(2), 601-604, ISSN: 0390-6078, PMID: 32381580,
MAJERA, D., Z. ŠKROTT, K. CHROMÁ, J. MERCHUT-MAYA, M. MISTRÍK, J. BÁRTEK
Targeting the NPL4 Adaptor of p97/VCP Segregase by Disulfiram as an Emerging Cancer Vulnerability Evokes Replication Stress and DNA Damage while Silencing the ATR Pathway. Cells. 2020, 9(2), pii: E469, ISSN: 2073-4409, PMID: 32085572,  PDF.
ŠKROTT, Z., D. MAJERA, J. GURSKÝ, T. BUCHTOVÁ, M. HAJDÚCH, M. MISTRÍK, J. BÁRTEK
Disulfiram's anti-cancer activity reflects targeting NPL4, not inhibition of aldehyde dehydrogenase. Oncogene. 2019, 38(40), 6711-6722, ISSN: 0950-9232, PMID: 31391554,

Open positions

1 Molecular and cellular biology
Project: DNA damage signaling in the cellular response to stress
Supervisors: Mistrík Martin Ph.D.
Available: 1
Intended for: Doctoral training
Summary: 1 place in full-time study
2 Molecular and Translational Medicine
Project: Cellular stress in health and disease
Supervisors: Mistrík Martin Ph.D., Moudrý Pavel Ph.D., Škrott Zdeněk Ph.D.
Available: 3
Intended for: Doctoral training
Project: Identification of cellular stress pathways essential for cancer cell survival
Supervisors: Mistrík Martin Ph.D.
Available: 1
Intended for: Doctoral training
Summary: 1 full-time position